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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Novel Arena of Nanocosmetics: Applications and their Remarkable Contribution in the Management of Dermal Disorders, Topical Delivery, Future Trends and Challenges

Author(s): Ashima Ahuja* and Meenakshi Bajpai

Volume 30, Issue 2, 2024

Published on: 10 January, 2024

Page: [115 - 139] Pages: 25

DOI: 10.2174/0113816128288516231228101024

Price: $65

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Abstract

Nanocosmetics have attracted a considerable audience towards natural care due to their low cost, target-specific delivery, and reduced toxicity compared to chemical-based cosmetics. Nanofomulations, including nanoemulsions, nanotubes, and polymeric carriers, have become next-generation products explored for the multifaced applications of nanotechnology in skin care. The rise in the cosmetic industry demands innovative and personalized products designed using nanocarriers for better targeting and improving patient compliance. Furthermore, nanocosmetics increase the efficiency of skin permeation active ingredient entrapment, providing better UV protection. Moreover, it offers controlled drug release, targeting active sites and enhancing physical stability. Further, overcoming the drawback of penetration problems makes them sustainable formulations for precision medicine. Skincare nourishment with nanocosmetics using Indian spices helps to maintain, beautify, and rejuvenate human skin. Nanophytopharmaceuticals extracted from plants, including alkaloids, flavonoids, antioxidants, and volatile oils, are essential phyto-products for skin care. Nano herbals and nanocosmetics are a growing market and gift of nature that nourishes and cures skin ailments like acne, pemphigus, anti-aging, albinism, psoriasis, and fungal infections. The emerging concern is highlighted in the investigation of nanoformulation toxicity and safety concerns in skin care. Further, it helps to manifest research, development, and innovation in expanding the scope of herbal industries.

Keywords: Skincare, nanotechnology nanocosmetics, precision medicine, skin ailments, nourishment, herbal industries.

[1]
Kazmi SK, Kauser N, Aman A, et al. Evaluation of the antibacterial potential of various plant extracts against clinically important skin infectious bacterial strains. Antiinfect Agents 2021; 19(1): 57-63.
[http://dx.doi.org/10.2174/2211352518999200626192714]
[2]
Kwan SH, Ismail MN. Discovery of Channa striata extracts as regenerative medicine in promoting wound healing and scarless skin regeneration. Nat Prod J 2020; 10(1): 1-8.
[3]
Choudhury H, Pandey M, Hua CK, et al. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med 2018; 8(3): 361-76.
[http://dx.doi.org/10.1016/j.jtcme.2017.08.012] [PMID: 29992107]
[4]
Kumar S, Swarankar V, Sharma S, Baldi A. Herbal cosmetics: Used for skin and hair. Inventi Rapid: Cosmeceut 2012; 4: 3-7.
[5]
Tiwari M, Dubey V, Lahiri A. Comparative study of various herbal cosmetics: A survey. Asian J Pharm Clin Res 2020; 13(10): 31-4.
[http://dx.doi.org/10.22159/ajpcr.2020.v13i10.38904]
[6]
Russo Serafini M, Gibara Guimaraes A, Jose Quintans-Junior L, et al. Recent patents on medicinal plants/natural products as a therapeutic approach to wounds and burns healing. Recent Pat Biotechnol 2015; 8(3): 231-9.
[http://dx.doi.org/10.2174/187220830803150605164205] [PMID: 27099146]
[7]
Aburjai T, Natsheh FM. Plants used in cosmetics. Phytother Res 2003; 17(9): 987-1000.
[http://dx.doi.org/10.1002/ptr.1363] [PMID: 14595575]
[8]
Roberts R. Beauty industry trends & cosmetics marketing: Statistics and strategies for your ecommerce growth. 2020. Available from: https://commonthreadco.com/blogs/coachs-corner/cosmetics-marketing-industry-trends.
[9]
Nozaki F. General aspects of cosmetics in relation to science and society: Social, Cultural, Science, and Marketing Aspects. In: Cosmetic Science and Technology: Theoretical Principles and Applications. Chapter 1, Elsevier 2017; pp. 3-14.
[http://dx.doi.org/10.1016/B978-0-12-802005-0.00001-X]
[10]
Venugopal J, Prabhakaran M, Low S, et al. Nanotechnology for nanomedicine and delivery of drugs. Curr Pharm Des 2008; 14(22): 2184-200.
[http://dx.doi.org/10.2174/138161208785740180] [PMID: 18781971]
[11]
Nasir A. Nanotechnology and dermatology: Part II-risks of nanotechnology. Clin Dermatol 2010; 28(5): 581-8.
[http://dx.doi.org/10.1016/j.clindermatol.2009.06.006] [PMID: 20797523]
[12]
Hadgraft J. Skin, the final frontier. Int J Pharm 2001; 224(1-2): 1-18.
[http://dx.doi.org/10.1016/S0378-5173(01)00731-1] [PMID: 11512545]
[13]
Guterres SS, Alves MP, Pohlmann AR. Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights 2007; 2: 117739280700200002.
[http://dx.doi.org/10.1177/117739280700200002] [PMID: 21901071]
[14]
Lademann J, Richter H, Teichmann A, et al. Nanoparticles - An efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm 2007; 66(2): 159-64.
[http://dx.doi.org/10.1016/j.ejpb.2006.10.019] [PMID: 17169540]
[15]
Barry BW. Modern methods of promoting drug absorption through the skin. Mol Aspects Med 1991; 12(3): 195-241.
[http://dx.doi.org/10.1016/0098-2997(91)90002-4] [PMID: 1770837]
[16]
Simple Home Remedies for Glowing Skin. Available from: https://pharmeasy.in/blog/simple-home-remedies-for-glowing-skin/
[17]
The 9 Best Herbs To Support Healthy, Glowing Skin from the Inside Out. Available from: https://www.gaiaherbs.com/blogs/seeds-of-knowledge/the-7-best-herbal-supplements-for-healthy-glowing-skin-from-the-inside-out (Accessed on August 22, 2023).
[18]
Kapoor VP. Herbal cosmetics for skin and hair care. Nat Prod Radiance 2005; 4(4): 306-14.
[19]
[20]
Chaiyana W, Anuchapreeda S, Somwongin S, et al. Dermal delivery enhancement of natural anti-ageing compounds from Ocimum sanctum linn. extract by nanostructured lipid carriers. Pharmaceutics 2020; 12(4): 309.
[http://dx.doi.org/10.3390/pharmaceutics12040309] [PMID: 32235376]
[21]
Tundis R, Loizzo MR, Bonesi M, Menichini F. Potential role of natural compounds against skin aging. Curr Med Chem 2015; 22(12): 1515-38.
[http://dx.doi.org/10.2174/0929867322666150227151809] [PMID: 25723509]
[22]
Chaiyana W, Anuchapreeda S, Punyoyai C, et al. Ocimum sanctum Linn. as a natural source of skin anti-ageing compounds. Ind Crops Prod 2019; 127: 217-24.
[http://dx.doi.org/10.1016/j.indcrop.2018.10.081]
[23]
Yadav N, Aggarwal R, Targhotra M, Sahoo PK, Chauhan MK. Natural and nanotechnology based treatment: An alternative approach to psoriasis. Curr Nanomed 2021; 11(1): 21-39.
[http://dx.doi.org/10.2174/2468187310999201022192318]
[24]
Rajeswari R, Umadevi M, Rahale CS. Aloe vera: The miracle plant its medicinal and traditional uses in india. J Pharmacogn Phytochem 2012; 1(4): 118-24.
[25]
Kumar KPS, Bhowmik D. Aloe vera: A potential herb and its medicinal importance. J Chem Pharm Res 2010; 2(1): 21-9.
[26]
Herbs for Psoriasis. Available from: https://www.healthline.com/health/herbs-for-psoriasis#herbs (Accessed on August 20, 2023).
[27]
Capsaicin Cream - Uses, Side Effects, and More. Available from: https://www.webmd.com/drugs/2/drug-4181/capsaicin-topical/details (Accessed February 15, 2023).
[28]
Capsaicin Topical. Available from: https://www.drugs.com/mtm/capsaicin-topical.html (Accessed May 16, 2023).
[29]
Uses of Capsaicin Cream. Available from: https://www.healthline.com/health/capsaicin-cream#side-effects (Accessed September 1, 2023).
[30]
Curcumin. Available from: https://www.slideshare.net/mokshacb/curcumin-60293131 (Accessed September 1, 2023).
[31]
Oregon Grape - Uses, Side Effects, and More. Available from: https://www.webmd.com/vitamins/ai/ingredientmono-493/oregon-grape (Accessed September 1, 2023).
[32]
What Is Oregon Grape? Uses and Side Effects. Available from: https://www.healthline.com/nutrition/oregon-grape#what-it-is (Accessed September 1, 2023).
[33]
Why Your Skin Will Love Berberis Aquifolium (Oregon Grape). Available from: https://rtpr.com/share/why-your-skin-will-love-berberis-aquifolium-oregon-grape (Accessed September 2, 2023).
[34]
Kazerouni A, Kazerouni O, Pazyar N. Effects of ginger (Zingiber officinale) on skin conditions: A non quantitative review article. J Turk Aca Dermato 2013; 7(2): 1-4.
[35]
Singh V, Verma R, Kaushik D, Mittal V. Recent patents on phytoconstituents-based formulations for the treatment of acne infection: A review. Recent Patents Anti-Infect Drug Disc 2020; 15(2): 119-36.
[http://dx.doi.org/10.2174/1574891X15666200929150103] [PMID: 32990540]
[36]
Sathish D, Shayeda , Madhusudan Rao Y. Acne and its treatment options: A review. Curr Drug Deliv 2011; 8(6): 634-9.
[http://dx.doi.org/10.2174/156720111797635540] [PMID: 21864255]
[37]
Svitina H, Swanepoel R, Rossouw J, Netshimbupfe H, Gouws C, Hamman J. Treatment of skin disorders with aloe materials. Curr Pharm Des 2019; 25(20): 2208-40.
[http://dx.doi.org/10.2174/1381612825666190703154244] [PMID: 31269881]
[38]
Green Tea for Your Skin. Available from: https://www.healthline.com/health/benefits-of-green-tea-for-skin (Accessed February 23, 2023).
[39]
All About Green Tea Extract. Available from: https://www.newdirectionsaromatics.com/blog/products/all-about-green-tea-botanical-extract.html (Accessed February 25, 2023).
[40]
Stay on Top of Your Skincare Routine with Products Clinically-Formulated to Help You Achieve Glowing Skin. Available from: https://www.katesomerville.com/us/en/blog/green-tea-extract-benefits-in-skin-care.html (Accessed May 28, 2023).
[41]
10 Benefits of Green Tea Extract. Available from: https://www.healthline.com/nutrition/10-benefits-of-green-tea-extract#7.-Its-Components-May-Be-Good-for-the-Skin (Accessed May 21, 2023).
[42]
Khan N, Mukhtar H. Tea polyphenols for health promotion. Life Sci 2007; 81(7): 519-33.
[http://dx.doi.org/10.1016/j.lfs.2007.06.011] [PMID: 17655876]
[43]
Cohen M. Tulsi - Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med 2014; 5(4): 251-9.
[http://dx.doi.org/10.4103/0975-9476.146554] [PMID: 25624701]
[44]
Try Tulsi for a Skin Detox. Available from: https://www.deccanherald.com/content/667464/try-tulsi-skin-detox.html (Accessed June 15, 2023).
[45]
Atmanto D. Effectiveness of utilizing VCO oil and castor oil on natural creams for dry skin treatment due to environmental factors. J Phys: Conf Ser 2019; 1402: 022093.
[http://dx.doi.org/10.1088/1742-6596/1402/2/022093]
[46]
Capsaicin Cream. Available from: https://dermnetnz.org/topics/capsaicin/#:~:text=Capsaicin%20is%20approved%20 (Accessed May 15, 2023).
[47]
Cayenne Pepper Can Help Cure Your Acne and Acne Scars. Available from: https://www.applerosebeauty.com/blogs/nature-and-beauty-meet-big-hearts/63375875-cayenne-pepper-can-help-cure-your-acne-and-acne-scars (Accessed May 15, 2023).
[49]
Healthline. Available from: https://www.healthline.com/health/pumpkin-seed-oil-acne (Accessed March 3, 2023).
[50]
What Are the Benefits of Using Sesame Oil on Your Skin? Available from: https://www.healthline.com/health/beauty-skin-care/sesame-oil-for-skin#bottom-line (Accessed July 15, 2023).
[51]
Coconut Oil For Face: Benefits and Home Remedies for Gorgeous Skin. Available from: https://swirlster.ndtv.com/beauty/the-amazing-skincare-benefits-and-uses-of-coconut-oil-for-the-face-2217561 (Accessed July 25, 2023).
[52]
Pandiselvam R, Manikantan MR, Beegum S, Mathew AC. Virgin coconut oil infused healthy cosmetics. Indian Coconut J 2019; 30-2.
[53]
Coconut Oil for Face: Benefits and Home Remedies for Gorgeous Skin. Available from: https://swirlster.ndtv.com/beauty/theamazing-skincare-benefits-and-uses-of-coconut-oil-for-the-face-2217561.
[54]
Peppermint Oil uses and Benefits to Try now for Beauty, Health and Home. Available from: https://www.today.com/style/peppermint-oil-uses-benefits-beauty-health-home-cleanliness-t145583 (Accessed August 9, 2022).
[55]
Onion - Uses, Side Effects, and More. Available from: https://www.webmd.com/vitamins/ai/ingredientmono-643/onion (Accessed August 20, 2023).
[56]
How to use Onion for Skin Care? Also Know the Benefits and Side Effects. Available from: https://www.beautyglimpse.com/onion-skin-care-use/ (Accessed August 11, 2023).
[57]
Skin Cancer. Available from: https://www.mayoclinic.org/diseases-conditions/skin-cancer/symptoms-causes/syc-20377605 (Accessed February 3, 2023).
[58]
Li JY, Kampp JT. Review of common alternative herbal “remedies” for skin cancer. Dermatol Surg 2019; 45(1): 58-67.
[http://dx.doi.org/10.1097/DSS.0000000000001622] [PMID: 30096105]
[59]
Farooqi A, Li RN, Huang HW, et al. Natural products mediated regulation of oxidative stress and DNA damage in ultraviolet exposed skin cells. Curr Pharm Biotechnol 2015; 16(12): 1078-84.
[http://dx.doi.org/10.2174/1389201016666150731111308] [PMID: 26238680]
[60]
Ebrahimabadi MH, Lamardi SNS, Shirbeigi L. Immunomodulatory effects of medicinal plants used for vitiligo in traditional persian. Curr Drug Discov Technol 2021; 18(2): 160-78.
[http://dx.doi.org/10.2174/1570163817666200517115438] [PMID: 32416680]
[61]
[62]
Fungal Infections of the Skin. Available from: https://www.webmd.com/skin-problems-and-treatments/guide/fungal-infections-skin (Accessed February 15, 2023).
[63]
Nolkemper S, Reichling J, Stintzing F, Carle R, Schnitzler P. Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro. Planta Med 2006; 72(15): 1378-82.
[http://dx.doi.org/10.1055/s-2006-951719] [PMID: 17091431]
[64]
Atarzadeh F, Jaladat AM, Daneshfard B, Dastgheib L, Kamalinejad M, Amin G. A review on botanicals with wound healing activity for Pemphigus vulgaris: Perspective of traditional Persian medicine and conventional medicine. Avicenna J Phytomed 2017; 7(6): 486-94.
[PMID: 29299431]
[65]
Ahuja A, Gupta J. Emerging approaches for management and treatment of Pemphigus vulgaris: Steps to improve health. Bull Env Pharmacol Life Sci 2020; 9(10): 06-10.
[66]
19 Herbal Remedies for Hair Growth. Available from: https://www.healthline.com/health/herbs-for-hair-growth (Accessed March 31, 2023).
[67]
Uyen LDP, Nguyen DH, Kim E-K. Mechanism of skin pigmentation. Biotechnol Bioprocess Eng; BBE 2008; 13(4): 383-95.
[http://dx.doi.org/10.1007/s12257-008-0143-z]
[69]
Simple Home Remedies for Hyperpigmentation. Available from: https://www.purplle.com/magazine/article/simple-home-remedies-for-hyperpigmentation (Accessed March 4, 2023).
[70]
Rathee P, Kumar S, Kumar D, Kumari B, Yadav SS. Skin hyperpigmentation and its treatment with herbs: An alternative method. Fut J Pharmaceut Sci 2021; 7(1): 132.
[http://dx.doi.org/10.1186/s43094-021-00284-6]
[71]
Is Coconut Oil Good for Your Skin? Available from: https://www.healthline.com/nutrition/coconut-oil-and-skin.
[72]
Ahuja A, Gupta J, Gupta R. Miracles of herbal phytomedicines in treatment of skin disorders: Natural healthcare perspective. Infect Disord Drug Targets 2021; 21(3): 328-38.
[http://dx.doi.org/10.2174/1871526520666200622142710] [PMID: 32568024]
[73]
Shree D, Patra CN, Sahoo BM. novel herbal nanocarriers for treatment of dermatological disorders. Pharm Nanotechnol 2022; 10(4): 246-56.
[http://dx.doi.org/10.2174/2211738510666220622123019] [PMID: 35733305]
[74]
Gupta S, Bansal R, Gupta S, Jindal N, Jindal A. Nanocarriers and nanoparticles for skin care and dermatological treatments. Indian Dermatol Online J 2013; 4(4): 267-72.
[http://dx.doi.org/10.4103/2229-5178.120635] [PMID: 24350003]
[75]
Verma S, Utreja P. Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy. Asian J Pharmaceut Sci 2019; 14(2): 117-29.
[http://dx.doi.org/10.1016/j.ajps.2018.05.007] [PMID: 32104444]
[76]
Duarah S, Durai RD, Narayanan VB. Nanoparticle-in-gel system for delivery of vitamin C for topical application. Drug Deliv Transl Res 2017; 7(5): 750-60.
[http://dx.doi.org/10.1007/s13346-017-0398-z] [PMID: 28597122]
[77]
Rodríguez-Félix F, Del-Toro-Sánchez CL, Javier Cinco-Moroyoqui F, et al. Preparation and characterization of quercetin-loaded zein nanoparticles by electrospraying and study of in vitro bioavailability. J Food Sci 2019; 84(10): 2883-97.
[http://dx.doi.org/10.1111/1750-3841.14803] [PMID: 31553062]
[78]
Sivarajakumar Raahulan, Sanapalli BKR, Karri VVSR. Paclitaxel loaded transfersomal vesicular drug delivery for the treatment of melanoma skin cancers. Int J Res Pharmaceut Sci 2019; 10(4): 2891-7.
[http://dx.doi.org/10.26452/ijrps.v10i4.1569]
[79]
Shrotriya S, Ranpise N, Satpute P, Vidhate B. Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis. Artif Cells Nanomed Biotechnol 2018; 46(7): 1471-82.
[http://dx.doi.org/10.1080/21691401.2017.1373659] [PMID: 28884598]
[80]
Khan S, Mulla G, Bhise K. Development and characterization of topical nanoparticulate antipsoriatic polyherbal cream. Int J Appl Pharmaceut 2020; 12(3): 67-73.
[http://dx.doi.org/10.22159/ijap.2020v12i3.36911]
[81]
Akhtar N, Varma A, Pathak K. Ethosomes as vesicles for effective transdermal delivery: From bench to clinical implementation. Curr Clin Pharmacol 2016; 11(3): 168-90.
[http://dx.doi.org/10.2174/1574884711666160813231352] [PMID: 27526697]
[82]
Romero E, Morilla M. Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations. Int J Nanomed 2013; 8: 3171-86.
[http://dx.doi.org/10.2147/IJN.S33048] [PMID: 23986634]
[83]
Blume A, Jansen M, Ghyczy M, Gareiss J. Interaction of phospholipid liposomes with lipid model mixtures for stratum corneum lipids. Int J Pharm 1993; 99(2-3): 219-28.
[http://dx.doi.org/10.1016/0378-5173(93)90364-L]
[84]
Mbah CC, Builders PF, Attama AA. Nanovesicular carriers as alternative drug delivery systems: Ethosomes in focus. Expert Opin Drug Deliv 2014; 11(1): 45-59.
[http://dx.doi.org/10.1517/17425247.2013.860130] [PMID: 24294974]
[85]
Godin B, Touitou E. Ethosomes: New prospects in transdermal delivery. Crit Rev Ther Drug Carrier Syst 2003; 20(1): 63-102.
[http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.v20.i1.20] [PMID: 12911264]
[86]
Yu Z, Lv H, Han G, Ma K. Ethosomes loaded with cryptotanshinone for acne treatment through topical gel formulation. PLoS One 2016; 11(7): e0159967.
[http://dx.doi.org/10.1371/journal.pone.0159967] [PMID: 27441661]
[87]
Salem HF, Kharshoum RM, Awad SM, Ahmed Mostafa M, Abou-Taleb HA. Tailoring of retinyl palmitate-based ethosomal hydrogel as a novel nanoplatform for acne vulgaris management: Fabrication, optimization, and clinical evaluation employing a split-face comparative study. Int J Nanomed 2021; 16: 4251-76.
[http://dx.doi.org/10.2147/IJN.S301597] [PMID: 34211271]
[88]
Negi P, Sharma I, Hemrajani C, et al. Thymoquinone-loaded lipid vesicles: A promising nanomedicine for psoriasis. BMC Complement Altern Med 2019; 19(1): 334.
[http://dx.doi.org/10.1186/s12906-019-2675-5] [PMID: 31771651]
[89]
Kollipara RK, Tallapaneni V, Sanapalli BKR, Kumar GV, Karri VVSR. Curcumin loaded ethosomal vesicular drug delivery system for the treatment of melanoma skin cancer. Res J Pharma Technol 2019; 12(4): 1783.
[http://dx.doi.org/10.5958/0974-360X.2019.00298.1]
[90]
Dave V, Bhardwaj N, Gupta N, Tak K. Herbal ethosomal gel containing luliconazole for productive relevance in the field of biomedicine. 3 Biotech 2020; 10(3): 97.
[http://dx.doi.org/10.1007/s13205-020-2083-z] [PMID: 32099738]
[91]
Forssen EA, Tökès ZA. Use of anionic liposomes for the reduction of chronic doxorubicin-induced cardiotoxicity. Proc Natl Acad Sci 1981; 78(3): 1873-7.
[http://dx.doi.org/10.1073/pnas.78.3.1873] [PMID: 6940195]
[92]
Bozzuto G, Molinari A. Liposomes as nanomedical devices. Int J Nanomedicine 2015; 10: 975-99.
[http://dx.doi.org/10.2147/IJN.S68861] [PMID: 25678787]
[93]
Madan S, Nehate C, Barman TK, Rathore AS, Koul V. Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: In vitro and in vivo studies. Drug Dev Ind Pharm 2019; 45(3): 395-404.
[http://dx.doi.org/10.1080/03639045.2018.1546310] [PMID: 30442066]
[94]
Pornpattananangkul D, Fu V, Thamphiwatana S, et al. In vivo treatment of Propionibacterium acnes infection with liposomal lauric acids. Adv Healthc Mater 2013; 2(10): 1322-8.
[http://dx.doi.org/10.1002/adhm.201300002] [PMID: 23495239]
[95]
Burchacka E, Potaczek P, Paduszyński P, Karłowicz-Bodalska K, Han T, Han S. New effective azelaic acid liposomal gel formulation of enhanced pharmaceutical bioavailability. Biomed Pharmacother 2016; 83: 771-5.
[http://dx.doi.org/10.1016/j.biopha.2016.07.014] [PMID: 27484346]
[96]
Ramesh V, Kumar KVA. Herbally medicated liposomal gel for acne vulgaris. World J Pharm Res 2017; 6(14): 507-29.
[97]
Singh R. Formulation of herbal liposomes containing green tea and gaultheria procumbens for anti-acne activity. Medicine 2012; 1211-6.
[98]
Singh A, Rathod VS. Design, development and characterization of liposomal neem gel. Int J Pharm Sci Res 2014; 5(4): 140-8.
[99]
Dave V, Sharma S, Yadav RB, Agarwal U. Herbal liposome for the topical delivery of ketoconazole for the effective treatment of seborrheic dermatitis. Appl Nanosci 2017; 7(8): 973-87.
[http://dx.doi.org/10.1007/s13204-017-0634-3]
[100]
Chorachoo J, Amnuaikit T, Voravuthikunchai SP. Liposomal encapsulated rhodomyrtone: A novel antiacne drug. Evid Based Complement Alternat Med 2013; 2013: 1-7.
[http://dx.doi.org/10.1155/2013/157635] [PMID: 23762104]
[101]
Zhou W, Liu W, Zou L, et al. Storage stability and skin permeation of vitamin C liposomes improved by pectin coating. Colloids Surf B Biointerfaces 2014; 117: 330-7.
[http://dx.doi.org/10.1016/j.colsurfb.2014.02.036] [PMID: 24681045]
[102]
Hussain A, Singh S, Sharma D, Webster T, Shafaat K, Faruk A. Elastic liposomes as novel carriers: Recent advances in drug delivery. Int J Nanomed 2017; 12: 5087-108.
[http://dx.doi.org/10.2147/IJN.S138267] [PMID: 28761343]
[103]
Benson HAE. Transfersomes for transdermal drug delivery. Expert Opin Drug Deliv 2006; 3(6): 727-37.
[http://dx.doi.org/10.1517/17425247.3.6.727] [PMID: 17076595]
[104]
Benson H. Elastic liposomes for topical and transdermal drug delivery. Curr Drug Deliv 2009; 6(3): 217-26.
[http://dx.doi.org/10.2174/156720109788680813] [PMID: 19604135]
[105]
Pandit J, Garg M, Jain NK. Miconazole nitrate bearing ultraflexible liposomes for the treatment of fungal infection. J Liposome Res 2014; 24(2): 163-9.
[http://dx.doi.org/10.3109/08982104.2013.871025] [PMID: 24479833]
[106]
Aggarwal N, Goindi S. Preparation and evaluation of antifungal efficacy of griseofulvin loaded deformable membrane vesicles in optimized guinea pig model of Microsporum canis-Dermatophytosis. Int J Pharm 2012; 437(1-2): 277-87.
[http://dx.doi.org/10.1016/j.ijpharm.2012.08.015] [PMID: 22939964]
[107]
Opatha SAT, Titapiwatanakun V, Chutoprapat R. Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics 2020; 12(9): 855.
[http://dx.doi.org/10.3390/pharmaceutics12090855] [PMID: 32916782]
[108]
Ezzat SM, Salama MM, ElMeshad AN, Teaima MH, Rashad LA. HPLC-DAD-MS/MS profiling of standardized rosemary extract and enhancement of its anti-wrinkle activity by encapsulation in elastic nanovesicles. Arch Pharm Res 2016; 39(7): 912-25.
[http://dx.doi.org/10.1007/s12272-016-0744-6] [PMID: 27107862]
[109]
Avadhani KS, Manikkath J, Tiwari M, et al. Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage. Drug Deliv 2017; 24(1): 61-74.
[http://dx.doi.org/10.1080/10717544.2016.1228718] [PMID: 28155509]
[110]
Wu PS, Li YS, Kuo YC, Tsai SJ, Lin CC. Preparation and evaluation of novel transfersomes combined with the natural antioxidant resveratrol. Molecules 2019; 24(3): 600.
[http://dx.doi.org/10.3390/molecules24030600] [PMID: 30743989]
[111]
Agrawal R, Sandhu SK, Sharma I, Kaur IP. Development and evaluation of curcumin-loaded elastic vesicles as an effective topical anti-inflammatory formulation. AAPS PharmSciTech 2015; 16(2): 364-74.
[http://dx.doi.org/10.1208/s12249-014-0232-6] [PMID: 25319056]
[112]
Patel R, Singh SK, Singh S. Development and characterization of curcumin loaded transfersome for transdermal delivery. J Pharm Sci Res 2009; 1(4): 71-80.
[113]
Kaur CD, Saraf S. Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation-damaged skin. J Cosmet Dermatol 2011; 10(4): 260-5.
[http://dx.doi.org/10.1111/j.1473-2165.2011.00586.x] [PMID: 22151933]
[114]
Shetty S, Shetty S. Cubosome-based cosmeceuticals: A breakthrough in skincare. Drug Discov Today 2023; 28(7): 103623.
[http://dx.doi.org/10.1016/j.drudis.2023.103623] [PMID: 37224997]
[115]
Tan C, Hosseini SF, Jafari SM. Cubosomes and hexosomes as novel nanocarriers for bioactive compounds. J Agric Food Chem 2022; 70(5): 1423-37.
[http://dx.doi.org/10.1021/acs.jafc.1c06747] [PMID: 35089018]
[116]
Rodero CF, Fioramonti Calixto GM, Cristina dos Santos K, et al. Curcumin-loaded liquid crystalline systems for controlled drug release and improved treatment of vulvovaginal candidiasis. Mol Pharm 2018; 15(10): 4491-504.
[http://dx.doi.org/10.1021/acs.molpharmaceut.8b00507] [PMID: 30184431]
[117]
Ferreira PS, Victorelli FD, Rodero CF, et al. p-Coumaric acid loaded into liquid crystalline systems as a novel strategy to the treatment of vulvovaginal candidiasis. Int J Pharm 2021; 603: 120658.
[http://dx.doi.org/10.1016/j.ijpharm.2021.120658] [PMID: 33964336]
[118]
Gosenca Mirjam. Lecithin based lamellar liquid crystals as a physiologically acceptable dermal delivery system for ascorbyl palmitate. Eur J Pharma Sci 2013; 50(1): 114-22.
[119]
Handjani-Vila RM, Ribier A, Rondot B, Vanlerberghie G. Dispersions of lamellar phases of non‐ionic lipids in cosmetic products. Int J Cosmet Sci 1979; 1(5): 303-14.
[http://dx.doi.org/10.1111/j.1467-2494.1979.tb00224.x] [PMID: 19467076]
[120]
Hamishehkar H, Rahimpour Y, Kouhsoltani M. Niosomes as a propitious carrier for topical drug delivery. Expert Opin Drug Deliv 2013; 10(2): 261-72.
[http://dx.doi.org/10.1517/17425247.2013.746310] [PMID: 23252629]
[121]
Choi MJ, Maibach HI. Liposomes and niosomes as topical drug delivery systems. Skin Pharmacol Physiol 2005; 18(5): 209-19.
[http://dx.doi.org/10.1159/000086666] [PMID: 16015019]
[122]
Abdelkader H, Alani AWG, Alany RG. Recent advances in non-ionic surfactant vesicles (niosomes): Self-assembly, fabrication, characterization, drug delivery applications and limitations. Drug Deliv 2014; 21(2): 87-100.
[http://dx.doi.org/10.3109/10717544.2013.838077] [PMID: 24156390]
[123]
Kassem MAA, Esmat S, Bendas ER, El-Komy MHM. Efficacy of topical griseofulvin in treatment of tinea corporis. Mycoses 2006; 49(3): 232-5.
[http://dx.doi.org/10.1111/j.1439-0507.2006.01221.x] [PMID: 16681816]
[124]
Alomrani AH, Al-Agamy MH, Badran MM. In vitro skin penetration and antimycotic activity of itraconazole loaded niosomes: Various non-ionic surfactants. J Drug Deliv Sci Technol 2015; 28: 37-45.
[http://dx.doi.org/10.1016/j.jddst.2015.04.009]
[125]
Wang Z, Liu L, Xiang S, et al. Formulation and characterization of a 3d-printed cryptotanshinone-loaded niosomal hydrogel for topical therapy of acne. AAPS PharmSciTech 2020; 21(5): 159.
[http://dx.doi.org/10.1208/s12249-020-01677-1] [PMID: 32476076]
[126]
Budhiraja A, Dhingra G. Development and characterization of a novel antiacne niosomal gel of rosmarinic acid. Drug Deliv 2015; 22(6): 723-30.
[http://dx.doi.org/10.3109/10717544.2014.903010] [PMID: 24786487]
[127]
Gupta A, Singh S, Kotla NG, Webster TJ. Formulation and evaluation of a topical niosomal gel containing a combination of benzoyl peroxide and tretinoin for antiacne activity. Int J Nanomedicine 2014; 10: 171-82.
[PMID: 25565812]
[128]
Aziz DE, Abdelbary AA, Elassasy AI. Implementing central composite design for developing transdermal diacerein-loaded niosomes: Ex vivo permeation and in vivo deposition. Curr Drug Deliv 2018; 15(9): 1330-42.
[http://dx.doi.org/10.2174/1567201815666180619105419] [PMID: 29921206]
[129]
Ansari MD, Saifi Z, Pandit J, et al. Spanlastics a novel nanovesicular carrier: Its potential application and emerging trends in therapeutic delivery. AAPS PharmSciTech 2022; 23(4): 112.
[http://dx.doi.org/10.1208/s12249-022-02217-9] [PMID: 35411425]
[130]
Shamma RN, Sayed S, Sabry NA, El-Samanoudy SI. Enhanced skin targeting of retinoic acid spanlastics: In vitro characterization and clinical evaluation in acne patients. J Liposome Res 2019; 29(3): 283-90.
[http://dx.doi.org/10.1080/08982104.2018.1552706] [PMID: 30501429]
[131]
Elhabak M, Ibrahim S, Abouelatta SM. Topical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin. Drug Deliv 2021; 28(1): 445-53.
[http://dx.doi.org/10.1080/10717544.2021.1886377] [PMID: 33620008]
[132]
Badria F, Mazyed E. Formulation of nanospanlastics as a promising approach for improving the topical delivery of a natural leukotriene inhibitor (3-acetyl-11-keto-β-boswellic acid): Statistical optimization, in vitro characterization, and ex vivo permeation study. Drug Des Devel Ther 2020; 14: 3697-721.
[http://dx.doi.org/10.2147/DDDT.S265167] [PMID: 32982176]
[133]
Santuso E, Soeratri W, Purwanti T. Characterization of spanlastic system loaded green tea extract as antioxidant for skin. Indo J Pharm Pharmaceut Sci 2023; 10(1): 30-7.
[http://dx.doi.org/10.20473/jfiki.v10i12023.30-37]
[134]
Gupta DK, Ahad A, Waheed A. Chapter 18 - Bilosomes: A novel platform for drug delivery. In: Systems of Nanovesicular Drug Delivery. Academic Press 2022.

[135]
Aziz DE, Abdelbary AA, Elassasy AI. Investigating superiority of novel bilosomes over niosomes in the transdermal delivery of diacerein. J Liposome Res 2018; 1-40.
[PMID: 29355060]
[136]
Farahmand S, Tajerzadeh H, Farboud ES. Formulation and evaluation of a vitamin C multiple emulsion. Pharm Dev Technol 2006; 11(2): 255-61.
[http://dx.doi.org/10.1080/10837450500464172] [PMID: 16749536]
[137]
Chen J, Cao Z, Cannon J, Fan Y, Baker JR Jr, Wang SH. Effective treatment of skin wounds co-infected with multidrug-resistant bacteria with a novel nanoemulsion. Microbiol Spectr 2022; 10(2): e02506-21.
[http://dx.doi.org/10.1128/spectrum.02506-21] [PMID: 35412373]
[138]
Cao Z, Spilker T, Fan Y, et al. Nanoemulsion is an effective antimicrobial for methicillin-resistant Staphylococcus aureus in infected wounds. Nanomedicine 2017; 12(10): 1177-85.
[http://dx.doi.org/10.2217/nnm-2017-0025] [PMID: 28447896]
[139]
Fan Y, Ciotti S, Cao Z, Eisma R, Baker J Jr, Wang SH. Screening of nanoemulsion formulations and identification of NB-201 as an effective topical antimicrobial for Staphylococcus aureus in a mouse model of infected wounds. Mil Med 2016; 181(5S): 259-64.
[http://dx.doi.org/10.7205/MILMED-D-15-00186] [PMID: 27168582]
[140]
Indu MN, Hatha AAM, Abirosh C, Harsha U, Vivekanandan G. Antimicrobial activity of some of the South-Indian spices against serotypes of Escherichia coli, Salmonella, Listeria monocytogenes and Aeromonas hydrophila. Braz J Microbiol 2006; 37(2): 153-8.
[http://dx.doi.org/10.1590/S1517-83822006000200011]
[141]
Kaur M, Nagpal M, Singh M, Singh TG, Aggarwal G, Dhingra GA. Improved antibacterial activity of topical gel-based on nanosponge carrier of cinnamon oil. Bioimpacts 2020; 11(1): 23-31.
[http://dx.doi.org/10.34172/bi.2021.04] [PMID: 33469505]
[142]
Chintan J. Nanocarriers: Drug delivery system. Nanocapsules 2021; 23(January): 125-38.
[143]
Erdoğar N, Akkın S, Bilensoy E. Nanocapsules for drug delivery: An updated review of the last decade. Recent Pat Drug Deliv Formul 2019; 12(4): 252-66.
[http://dx.doi.org/10.2174/1872211313666190123153711] [PMID: 30674269]
[144]
Flores FC, de Lima JA, da Silva CR, et al. Hydrogels containing nanocapsules and nanoemulsions of tea tree oil provide antiedematogenic effect and improved skin wound healing. J Nanosci Nanotechnol 2015; 15(1): 800-9.
[http://dx.doi.org/10.1166/jnn.2015.9176] [PMID: 26328444]
[145]
Nguyen HTP, Munnier E, Perse X, et al. Qualitative and quantitative study of the potential of lipid nanocapsules of one hundred twenty nanometers for the topical administration of hydrophobic molecules. J Pharma Sci 2016; 1-8.
[146]
Hussein A, Abdel-Mottaleb MMA, El-assal M, Sammour O. Novel biocompatible essential oil-based lipid nanocapsules with antifungal properties. J Drug Deliv Sci Technol 2020; 56: 101605.
[http://dx.doi.org/10.1016/j.jddst.2020.101605]
[147]
Sadak Vali C, Abdullah Khan M. Development and characterization of eucalyptus oil loaded poly lactic co-glycolic acid - albumin nanocapsules. Int J Pharm Sci Rev Res 2021; 68(1): 206-12.
[148]
Marchiori MCL, Rigon C, da S Jardim F, et al. Hydrogel containing silibinin-loaded pomegranate oil-based nanocapsules for cutaneous application: In vitro safety investigation and human skin biometry and permeation studies. AAPS PharmSciTech 2023; 24(6): 138.
[http://dx.doi.org/10.1208/s12249-023-02606-8] [PMID: 37349650]
[149]
Gallarate M, Carlotti ME, Trotta M, Bovo S. On the stability of ascorbic acid in emulsified systems for topical and cosmetic use. Int J Pharm 1999; 188(2): 233-41.
[http://dx.doi.org/10.1016/S0378-5173(99)00228-8] [PMID: 10518678]
[150]
Rozman B, Zvonar A, Falson F, Gasperlin M. Temperature-sensitive microemulsion gel: An effective topical delivery system for simultaneous delivery of vitamins C and E. AAPS PharmSciTech 2009; 10(1): 54-61.
[http://dx.doi.org/10.1208/s12249-008-9172-3] [PMID: 19148763]
[151]
Akhtar N, Yazan Y. Formulation and in-vivo evaluation of a cosmetic multiple emulsion containing vitamin C and wheat protein. Pak J Pharm Sci 2008; 21(1): 45-50.
[PMID: 18166519]
[152]
Cizauskaite U, Bernatoniene J. Innovative natural ingredients-based multiple emulsions: The effect on human skin moisture, sebum content, pore size and pigmentation. Molecules 2018; 23(6): 1428.
[http://dx.doi.org/10.3390/molecules23061428] [PMID: 29895799]
[153]
Stolić Jovanović A, Martinović M, Žugić A, et al. Derivatives of L-Ascorbic acid in emulgel: Development and comprehensive evaluation of the topical delivery system. Pharmaceutics 2023; 15(3): 813.
[http://dx.doi.org/10.3390/pharmaceutics15030813] [PMID: 36986679]
[154]
Khan H, Akhtar N. Synergistic effects of ascorbyl palmitate and sodium ascorbyl phosphate loaded in multiple emulsions on facial skin melanin and erythema content. Biomed Res J 2016; 27: 570-6.
[155]
Aldawsari HM, Badr-Eldin SM, Labib GS, El-Kamel AH. Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: In vitro/in vivo evaluation. Int J Nanomed 2015; 10: 893-902.
[PMID: 25673986]
[156]
Kumar S, Pooja , Trotta F, Rao R. Encapsulation of babchi oil in cyclodextrin-based nanosponges: Physicochemical characterization, photodegradation, and in vitro cytotoxicity studies. Pharmaceutics 2018; 10(4): 169.
[http://dx.doi.org/10.3390/pharmaceutics10040169] [PMID: 30261580]
[157]
Iriventi P, Gupta NV, Osmani RAM, Balamuralidhara V. Design & development of nanosponge loaded topical gel of curcumin and caffeine mixture for augmented treatment of psoriasis. Daru 2020; 28(2): 489-506.
[http://dx.doi.org/10.1007/s40199-020-00352-x] [PMID: 32472531]
[158]
Ferraris C, Rimicci C, Garelli S, Ugazio E, Battaglia L. Nanosystems in cosmetic products: A brief overview of functional, market, regulatory and safety concerns. Pharmaceutics 2021; 13(9): 1408.
[http://dx.doi.org/10.3390/pharmaceutics13091408] [PMID: 34575484]
[159]
SCCS. Opinion on Titanium Dioxide (Nano Form). Brussels, Belgium: Scientific Committee on Consumer Safety 2013.
[160]
SCCS. Opinion on Titanium Dioxide (Nano Form) as UV-Filter in Sprays. Brussels, Belgium: Scientific Committee on Consumer Safety 2018.
[161]
SCCS. Opinion on Additional Coatings for Titanium Dioxide (Nano Form) as UV-Filter in Dermally Applied Cosmetic Products. Brussels, Belgium: Scientific Committee on Consumer Safety 2016.
[162]
SCCS. Opinion on Carbon Black (Nano Form). Brussels, Belgium: Scientific Committee on Consumer Safety 2013.
[163]
SCCS. Opinion on Colloidal Silver (Nano). Brussels, Belgium: Scientific Committee on Consumer Safety 2018.
[164]
SCCS. Opinion on Silica, Hydrated Silica, and Silica Surface Modified with Alkyl Silylates (Nano Form). Brussels, Belgium: Scientific Committee on Consumer Safety 2015.
[165]
SCCS. Opinion on Solubility of Synthetic Amorphous Silica (SAS). Brussels, Belgium: Scientific Committee on Consumer Safety 2019.
[166]
SCCS. Preliminary Opinion on Copper (Nano) and Colloidal Copper (Nano). Brussels, Belgium: Scientific Committee on Consumer Safety 2020.
[167]
SCCS. Opinion on Zinc Oxide (Nano Form). Brussels, Belgium: Scientific Committee on Consumer Safety 2012.
[168]
Morganti P, Chen HD, Morganti G. Nanocosmetics: Future perspective. In: Nanocosmetics. Elsevier 2020; pp. 455-81.
[http://dx.doi.org/10.1016/B978-0-12-822286-7.00020-6]
[169]
Method of making liposomes, liposome compositions made by the methods, and methods of using the same. U.S. Patent 20120171280A1, 2020.
[170]
Compositions for preventing or treating skin diseases comprising nanoliposomes and natural extracts. K.R. Patent 100752990B1, 2020.
[171]
Liposome-based topical vitamin d formulation. W.O. Patent 1997037637A1, 2020.
[172]
Liposome encapsulating herbal extracts and the method for preparing the same. K.R. Patent 20130025988A, 2020.
[173]
Spun gold royal chrysanthemum nanotechnology skin care product and preparation method and application thereof. C.N. Patent 111481481A, 2020.
[174]
Nano-emulsion cosmetic composition containing wild flower and preparing the same. K.R. Patent 20100092594A, 2020.
[175]
A skin whintening cosmetic composition containing a oriental herb extracts mixture stabilized by nanoliposome. K.R. Patent 20100092922A, 2020.

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