Yiqi Jiedu Xiaoying Decoction Improves Experimental Autoimmune
Thyroiditis in Rats by Regulating Th17/Treg Cell Balance

Hui      Zhu; Shumin      Mu; Shiyin      Liu; Yang      Cui; Jianyu      Ren; Enquan      Yang; Lining      Wang; Xiaoke      Cui; Ailing      Ren

doi:10.2174/0118715303256311231122094516

Abstract

Background: Experimental autoimmune thyroiditis (EAT) is a widely used animal model to study the pathogenesis and treatment of autoimmune thyroid diseases. Yiqi Jiedu Xiaoying Decoction (YJXD) is a traditional Chinese medicine formula with potential immunomodulatory effects. In this study, we investigated the therapeutic effects of YJXD on EAT in rats and explored its underlying mechanisms.

Methods: Female Wistar rats were induced to develop EAT by immunization with thyroglobulin (Tg) and taken sodium iodide water (0.05%) and then treated with YJXD or sodium selenite. HE staining was used to observe the pathological changes of thyroid tissue in EAT rats. Th17 and Treg cell frequencies were analyzed by flow cytometry, and the expression levels of Th17- and Treg-related cytokines and thyroid autoantibody were determined by enzyme-linked immunosorbent assay (ELISA). The expression of Th17- and Treg-related transcriptional factors was detected by real-time polymerase chain reaction (RT-PCR) and Immunohistochemistry (IHC).

Results: Our results demonstrated that treatment with YJXD significantly attenuated the severity of EAT, as evidenced by reduced thyroid gland inflammatory infiltration and decreased serum thyroglobulin autoantibody levels. Importantly, YJXD treatment effectively modulated the Th17/Treg cell balance by suppressing Th17 cell differentiation and promoting Treg cell expansion. Moreover, YJXD was also found to regulate the expression levels of Th17- and Treg-related cytokines and transcriptional factors, further supporting its immunomodulatory effects in EAT.

Conclusion: YJXD exerted therapeutic effects on EAT by regulating the Th17/Treg cell balance, modulating the production of Th17- and Treg-related cytokines and the expression of transcriptional factors.

Keywords: Yiqi Jiedu Xiaoying Decoction, experimental autoimmune thyroiditis (EAT), autoimmune thyroiditis (AIT), cytokines, immunomodulatory effects, transcriptional factor.

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DOI https://dx.doi.org/10.2174/0118715303256311231122094516	Print ISSN 1871-5303
Publisher Name Bentham Science Publisher	Online ISSN 2212-3873

Endocrine, Metabolic & Immune Disorders - Drug Targets

Yiqi Jiedu Xiaoying Decoction Improves Experimental Autoimmune Thyroiditis in Rats by Regulating Th17/Treg Cell Balance

Abstract

Graphical Abstract

Chronic inflammation and Disorders/Cancers

Immune defense of the blood-tissue barriers which are related to drugs, metabolic and hormones

Endocrine, Metabolic & Immune Disorders - Drug Targets

Yiqi Jiedu Xiaoying Decoction Improves Experimental Autoimmune Thyroiditis in Rats by Regulating Th17/Treg Cell Balance

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Chronic inflammation and Disorders/Cancers

Immune defense of the blood-tissue barriers which are related to drugs, metabolic and hormones

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