Title:Bile Acid-conjugate as a Promising Anticancer Agent: Recent Progress
Volume: 31
Issue: 26
关键词:
胆汁酸，胆汁酸缀合物，抗癌活性，生物利用度，超分子，细胞毒性药物。
摘要: Bile acids have outstanding chemistry due to their amphiphilic nature and have
received a lot of interest in the last few decades in the fields of biomedicine, pharmacology,
and supramolecular applications. Bile acids are highly sought after by scientists looking
for diverse and effective biological activity due to their chirality, rigidity, and hydroxyl
group. The hydroxyl group makes it simple to alter the structure in a way that improves
bioactivity and bioavailability. Bile acid-bioactive molecule conjugates are compounds in
which a bile acid is linked to a bioactive molecule by a linker in order to increase the bioactivity
of the bioactive molecule against the target cancer cells. This method has been
used to improve the therapeutic efficacy of cytotoxic drugs while reducing their adverse
side effects. These new bile acid conjugates are gaining attention because they overcome
bioavailability and stability issues. The design, synthesis, and anticancer effectiveness of
various bile acid conjugates are discussed together with recent advances in understanding
in this review.
