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Review Article

靶向NLRP3炎性小体:结构、功能和抑制剂

卷 31, 期 15, 2024

发表于: 02 January, 2024

页: [2021 - 2051] 页: 31

弟呕挨: 10.2174/0109298673289984231127062528

价格: $65

摘要

炎性小体是一种多聚体蛋白复合物，可以检测各种生理刺激和危险信号。因此，它们在先天免疫反应中起着至关重要的作用。NLRP3炎性小体作为炎性小体家族的重要组成部分，在防御病原体入侵和保持细胞稳态方面具有重要意义。NLRP3炎性小体失调与多种病理状况有关，包括炎症性疾病、癌症、心血管和神经退行性疾病。这使得NLRP3成为治疗相关疾病的适用靶点，因此，越来越多的NLRP3抑制剂被披露用于治疗。在此，我们总结了NLRP3炎症小体的结构、功能和抑制剂的最新进展。并对现有产品及未来药物研发方向进行了综述。

关键词: NLRP3，炎性体，功能，抑制剂，药物发现，蛋白复合物。

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