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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Targeting NLRP3 Inflammasome: Structure, Function, and Inhibitors

Author(s): Shengying Lou, Miaolian Wu* and Sunliang Cui*

Volume 31, Issue 15, 2024

Published on: 02 January, 2024

Page: [2021 - 2051] Pages: 31

DOI: 10.2174/0109298673289984231127062528

Price: $65

Abstract

Inflammasomes are multimeric protein complexes that can detect various physiological stimuli and danger signals. As a result, they perform a crucial function in the innate immune response. The NLRP3 inflammasome, as a vital constituent of the inflammasome family, is significant in defending against pathogen invasion and preserving cellhomeostasis. NLRP3 inflammasome dysregulation is connected to various pathological conditions, including inflammatory diseases, cancer, and cardiovascular and neurodegenerative diseases. This profile makes NLRP3 an applicable target for treating related diseases, and therefore, there are rising NLRP3 inhibitors disclosed for therapy. Herein, we summarized the updated advances in the structure, function, and inhibitors of NLRP3 inflammasome. Moreover, we aimed to provide an overview of the existing products and future directions for drug research and development.

Keywords: NLRP3, inflammasome, function, inhibitor, drug discovery, protein complexes.

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