Title:Global Epidemiology, Clinical Features, Diagnosis and Current Therapeutic
Novelties in Migraine Therapy and their Prevention: A Narrative Review
Volume: 29
Issue: 41
Author(s): Mohammad Daud Ali*, Fehmida Gayasuddin Qur, Md. Sarfaraz Alam, Nawaf M. Alotaibi and Md. Ali Mujtaba
Affiliation:
- Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Abdulrazaq Bin Hammam Street, Al Safa, Dammam
34222, Saudi Arabia
Keywords:
Migraine, epidemiology, acute treatment, preventive treatment, clinical features.
Abstract:
Introduction: The current article reviews the latest information on epidemiology, clinical features,
diagnosis, recent advancements in clinical management, current therapeutic novelties, and the prevention of
migraines. In a narrative review, all studies as per developed MeSH terms published until February 2023, excluding
those irrelevant, were identified through a PubMed literature search.
Methods: Overall, migraine affects more than a billion people annually and is one of the most common neurological
illnesses. A wide range of comorbidities is associated with migraines, including stress and sleep disturbances.
To lower the worldwide burden of migraine, comprehensive efforts are required to develop and enhance
migraine treatment, which is supported by informed healthcare policy. Numerous migraine therapies
have been successful, but not all patients benefit from them.
Results: CGRP pathway-targeted therapy demonstrates the importance of translating mechanistic understanding
into effective treatment. In this review, we discuss clinical features, diagnosis, and recently approved
drugs, as well as a number of potential therapeutic targets, including pituitary adenylate cyclase-activating
polypeptide (PACAP), adenosine, opioid receptors, potassium channels, transient receptor potential ion channels
(TRP), and acid-sensing ion channels (ASIC).
Conclusion: In addition to providing more treatment options for improved clinical care, a better understanding
of these mechanisms facilitates the discovery of novel therapeutic targets.
