Title:Biosensor Detection of COVID-19 in Lung Cancer: Hedgehog and Mucin
Signaling Insights
Volume: 29
Issue: 43
Author(s): Harneet Marwah, Janmejay Pant, Jiten Yadav, Kamal Shah and Hitesh Kumar Dewangan*
Affiliation:
- University Institute of Pharma Sciences (UIPS), Chandigarh University, NH-95 Chandigarh Ludhiana Highway, Mohali, Punjab,
India
Keywords:
Biosensors, COVID-19, diagnostic imaging, hedgehog signaling, lung cancer, mucin signaling.
Abstract: Coronavirus disease 2019 is a global pandemic, particularly affecting individuals with pre-existing
lung conditions and potentially leading to pulmonary fibrosis. Age and healthcare system limitations further
amplify susceptibility to both diseases, especially in low- and middle-income countries. The intricate relationship
between Coronavirus disease 2019 and lung cancer highlights their clinical implications and the potential
for early detection through biosensor techniques involving hedgehog and mucin signaling. This study highlights
the connection between Coronavirus disease 2019 and lung cancer, focusing on the mucosa, angiotensin-
altering enzyme 2 receptors, and their impact on the immune system. It details the inflammatory mechanisms
triggered by Coronavirus disease 2019, which can result in pulmonary fibrosis and influence the cancer
microenvironment. Various cytokines like Interleukins-6 and Tumor Necrosis Factor-alpha are examined for
their roles in both diseases. Moreover, the review delves into the Hedgehog signaling pathways and their significance
in lung cancer, particularly their influence on embryonic cell proliferation and tissue integrity. Mucin
signaling is another vital aspect, highlighting the diverse mucin expression patterns in respiratory epithelial tissues
and their potential as biomarkers. The review concludes with insights into diagnostic imaging techniques
like chest computed tomography, Positron Emission Tomography and Computed Tomography, and Magnetic
Resonance Imaging for early lung cancer detection, emphasizing the crucial role of biosensors in identifying
specific biomarkers for early disease detection. This review provides a comprehensive overview of the clinical
impact of Coronavirus disease 2019 on lung cancer patients and the potential for biosensors utilizing hedgehog
and mucin signaling for early detection. It underscores the ongoing need for research and innovation to address
these critical healthcare challenges.
