Title:Recent Updates on the Development of Therapeutics for the Targeted
Treatment of Alzheimer’s Disease
Volume: 29
Issue: 35
Author(s): Shivam Rajput, Rishabha Malviya*, Shiv Bahadur and Dinesh Puri
Affiliation:
- Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India
Keywords:
Neurodegeneration, Alzheimer’s disease, potential targets, therapeutics, neural disorders, pathophysiology.
Abstract: Alzheimer's disease (AD) is a complicated, multifaceted, irreversible, and incurable neurotoxic old
age illness. Although NMDA (N-methyl D-aspartate)-receptor antagonists, cholinesterase repressors, and their
pairings have been approved for the treatment, they are useful for short symptomatic relief. Researchers
throughout the globe have been constantly working to uncover the therapy of Alzheimer's disease as new candidates
must be determined, and newer treatment medicines must be developed. The aim of this review is to address
recent advances in medication research along with new Alzheimer's disease therapy for diverse targets.
Information was gathered utilizing a variety of internet resources as well as websites, such as ALZFORUM
(alzforum.org) and clinicaltrials.gov. In contrast to other domains, the proposed medicines target amyloids
(secretases, A42 generation, neuroinflammation, amyloid precipitation, and immunization), tau proteins (tau
phosphorylation/aggregation and immunotherapy), and amyloid deposition. Despite tremendous advancement
in our understanding of the underlying pathophysiology of Alzheimer's disease, the FDA (Food and Drug Administration)
only approved aducanumab for diagnosis and treatment in 2003. Hence, novel treatment tactics
are needed to find and develop therapeutic medicines to combat Alzheimer's disease.