Title:Advances in Understanding the Notch Signaling Pathway in the Cochlea
Volume: 29
Issue: 41
Author(s): Xiaoying Chen, Huanzhi Wan, Yutong Bai, Yuanyuan Zhang*Qingquan Hua*
Affiliation:
- Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
Keywords:
Notch signaling pathway, cochlear development, hair cells, supporting cells, hearing, regeneration.
Abstract: The cochlear structure is highly complex and specific, and its development is regulated by multiple
signaling pathways. Abnormalities in cochlear development can lead to different degrees of loss of function.
Hair cells (HCs), which are difficult to regenerate in the mature mammalian cochlea, are susceptible to damage
from noise and ototoxic drugs, and damage to HCs can cause hearing loss to varying degrees. Notch, a
classical developmental signaling molecule, has been shown to be closely associated with embryonic cochlear
development and plays an important role in HC regeneration in mammals, suggesting that the Notch signaling
pathway may be a potential therapeutic target for cochlear development and hearing impairment due to HC damage.
In recent years, the important role of the Notch signaling pathway in the cochlea has received increasing
attention. In this paper, we review the role of Notch signaling in cochlear development and HC regeneration,
with the aim of providing new research ideas for the prevention and treatment of related diseases.