Title:Optimization of Cobalt-Chromium (Co-Cr) Scaffolds for Bone Tissue
Engineering in Endocrine, Metabolic and Immune Disorders
Volume: 24
Issue: 4
Author(s): Óscar Libardo Rodríguez-Montaño, Lorenzo Vaiani, Antonio Boccaccio*, Antonio Emmanuele Uva, Lorenzo Lo Muzio, Francesca Spirito, Mario Dioguardi, Luigi Santacroce, Michele Di Cosola, Stefania Cantore*Andrea Ballini
Affiliation:
- Department of Mechanics, Mathematics and Management, Polytechnic University of Bari, Bari, Italy
- Department of Mechanics, Mathematics and Management, Polytechnic University of Bari, Bari, Italy
- Independent Researcher, Sorriso &
Benessere - Ricerca e Clinica, Bari, Italy
- Department of Precision Medicine, University of Campania "Luigi Vanvitelli",
Naples, Italy
Keywords:
3D-printed scaffolds, cobalt-chromium (Co-Cr) bioscaffolds, endocrine metabolic and immune disorders, customized medicine, regenerative medicine, tissue engineering, translational medicine.
Abstract: Approximately 50% of the adult global population is projected to suffer from some
form of metabolic disease by 2050, including metabolic syndrome and diabetes mellitus. At the
same time, this trend indicates a potential increase in the number of patients who will be in need
of implant-supported reconstructions of specific bone regions subjected to inflammatory states.
Moreover, physiological conditions associated with dysmetabolic subjects have been suggested
to contribute to the severity of bone loss after bone implant insertion. However, there is a perspective
evidence strengthening the hypothesis that custom-fabricated bioengineered scaffolds
may produce favorable bone healing effects in case of altered endocrine or metabolic conditions.
This perspective review aims to share a comprehensive knowledge of the mechanisms
implicated in bone resorption and remodelling processes, which have driven researchers to develop
metallic implants as the cobalt-chromium (Co-Cr) bioscaffolds, presenting optimized geometries
that interact in an effective way with the osteogenetic precursor cells, especially in the
cases of perturbed endocrine or metabolic conditions.