Bioinformatics-based Analysis of the Variability of MPOX Virus Proteins

Title:Bioinformatics-based Analysis of the Variability of MPOX Virus Proteins

Volume: 21 Issue: 15

Author(s): Carlos Polanco*, Alberto Huberman, Enrique Hernandez Lemus, Vladimir N. Uversky, Martha Rios Castro, Mireya Martinez Garcia, Gilberto Vargas-Alarcon, Thomas Buhse, Claudia Pimentel Hernández, Cecilia Zazueta, Francisco J. Roldan Gomez and Erika Jeannette López Oliva

Affiliation:

• Department of Electromechanical Instrumentation, Instituto Nacional de Cardiología “Ignacio Chávez”, Mexico City, 14080, Mexico
• Department of Mathematics, Faculty of Sciences, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico

Keywords: MPOX, MPOX gene, MPOX mutant proteins, structural proteomics, bioinformatics, intrinsic disorder predisposition, polarity index method profile.

Abstract: Background: Previously restricted to remote areas of Central and Western Africa, the MPOX virus-based disease, also known as monkeypox, has now spread to more than 90 countries and has become endemic. As a consequence, the MPOX virus has become a global public health concern.

Objective: The objective of this study was to conduct a computational-multiparametric study (at the genomic and proteomic levels) of the biological sequences that express the MPOX virus envelopes in order to fathom the physicochemical regularities of these proteins.

Methods: Using computer programs, we determined the polarity index method (PIM) profile and protein intrinsic disorder predisposition (PIDP) for each studied protein.

Results: The UniProt database was able to identify sequences similar to those of the MPOX virus expressed thanks to the computational regularities found in the virus' envelope sequences.

Conclusion: The polarity index method and protein intrinsic disorder predisposition profiles could aid in elucidating the sequence-level structural regularities of the MPOX virus envelopes.

Cite this article as:

Polanco Carlos*, Huberman Alberto, Lemus Hernandez Enrique, Uversky N. Vladimir, Rios Castro Martha, Garcia Martinez Mireya, Vargas-Alarcon Gilberto, Buhse Thomas, Hernández Pimentel Claudia, Zazueta Cecilia, Roldan Gomez J. Francisco and López Oliva Jeannette Erika, Bioinformatics-based Analysis of the Variability of MPOX Virus Proteins, Letters in Drug Design & Discovery 2024; 21 (15) . https://dx.doi.org/10.2174/0115701808260478231023080842