Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Perspective

The Thyroid-cardiac Axis: Thyroid Function, Cardiac Rhythmology, and Sudden Cardiac Death

Author(s): Michael Spartalis*, Eleftherios Spartalis, Stavroula A. Paschou, Dimitrios C. Iliopoulos and Gerasimos Siasos

Volume 24, Issue 10, 2024

Published on: 03 November, 2023

Page: [1127 - 1130] Pages: 4

DOI: 10.2174/0118715303243951231024112208

conference banner
Abstract

It is well known that thyroid dysfunction increases the risk of cardiovascular mortality and morbidity. The pleiotropic effect of thyroid hormones has a profound effect on the cardiovascular system, influencing both the formation of a normal cardiac rhythm and rhythm disturbance. A number of research studies have demonstrated correlations between TSH and FT4 levels and significant cardiovascular events. The pathophysiological mechanisms underlying these complex associations are, however, inadequately defined. A system-based examination of the relationship between thyroid homeostasis and cardiovascular disease could pave the way for novel study areas and a more individualised strategy for the management of individuals at cardiovascular risk.

Keywords: Thyroid, arrhythmia, sudden cardiac death, hyperthyroidism, hypothyroidism, cardiovascular.

Next »
[1]
Empana, J.P.; Lerner, I.; Valentin, E.; Folke, F.; Böttiger, B.; Gislason, G.; Jonsson, M.; Ringh, M.; Beganton, F.; Bougouin, W.; Marijon, E.; Blom, M.; Tan, H.; Jouven, X. ESCAPE-NET Investigators. Incidence of sudden cardiac death in the european union. J. Am. Coll. Cardiol., 2022, 79, 1818-1827.
[http://dx.doi.org/10.1016/j.jacc.2022.02.041] [PMID: 35512862]
[2]
Kumar, A.; Avishay, D.M.; Jones, C.R.; Shaikh, J.D.; Kaur, R.; Aljadah, M.; Kichloo, A.; Shiwalkar, N.; Keshavamurthy, S. Sudden cardiac death: Epidemiology, pathogenesis and management. Rev. Cardiovasc. Med., 2021, 22(1), 147-158.
[http://dx.doi.org/10.31083/j.rcm.2021.01.207] [PMID: 33792256]
[3]
Rogers, A.J.; Selvalingam, A.; Alhusseini, M.I.; Krummen, D.E.; Corrado, C.; Abuzaid, F.; Baykaner, T.; Meyer, C.; Clopton, P.; Giles, W.; Bailis, P.; Niederer, S.; Wang, P.J.; Rappel, W.J.; Zaharia, M.; Narayan, S.M. Machine learned cellular phenotypes in cardiomyopathy predict sudden death. Circ. Res., 2021, 128(2), 172-184.
[http://dx.doi.org/10.1161/CIRCRESAHA.120.317345] [PMID: 33167779]
[4]
Müller, P.; Leow, M.K.S.; Dietrich, J.W. Minor perturbations of thyroid homeostasis and major cardiovascular endpoints—Physiological mechanisms and clinical evidence. Front. Cardiovasc. Med., 2022, 9, 942971.
[http://dx.doi.org/10.3389/fcvm.2022.942971] [PMID: 36046184]
[5]
Gräsner, J.T.; Lefering, R.; Koster, R.W.; Masterson, S.; Böttiger, B.W.; Herlitz, J.; Wnent, J.; Tjelmeland, I.B.; Ortiz, F.R.; Maurer, H.; Baubin, M.; Mols, P. Hadžibegović, I.; Ioannides, M.; Škulec, R.; Wissenberg, M.; Salo, A.; Hubert, H.; Nikolaou, N.I.; Lóczi, G.; Svavarsdóttir, H.; Semeraro, F.; Wright, P.J.; Clarens, C.; Pijls, R.; Cebula, G.; Correia, V.G.; Cimpoesu, D.; Raffay, V.; Trenkler, S.; Markota, A.; Strömsöe, A.; Burkart, R.; Perkins, G.D.; Bossaert, L.L. EuReCa ONE-27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation, 2016, 105, 188-195.
[PMID: 27321577]
[6]
Hayashi, M.; Shimizu, W.; Albert, C.M. The spectrum of epidemiology underlying sudden cardiac death. Circ. Res., 2015, 116(12), 1887-1906.
[http://dx.doi.org/10.1161/CIRCRESAHA.116.304521] [PMID: 26044246]
[7]
Trayanova, N.A. Learning for prevention of sudden cardiac death. Circ. Res., 2021, 128(2), 185-187.
[http://dx.doi.org/10.1161/CIRCRESAHA.120.318576] [PMID: 33476206]
[8]
Wong, C.X.; Brown, A.; Lau, D.H.; Chugh, S.S.; Albert, C.M.; Kalman, J.M.; Sanders, P. Epidemiology of sudden cardiac death: global and regional perspectives. Heart Lung Circ., 2019, 28(1), 6-14.
[http://dx.doi.org/10.1016/j.hlc.2018.08.026] [PMID: 30482683]
[9]
Breitenstein, A.; Steffel, J. Devices in heart failure patients-who benefits from ICD and CRT? Front. Cardiovasc. Med., 2019, 6, 111.
[http://dx.doi.org/10.3389/fcvm.2019.00111] [PMID: 31457018]
[10]
Kusumoto, F.M.; Calkins, H.; Boehmer, J.; Buxton, A.E.; Chung, M.K.; Gold, M.R.; Hohnloser, S.H.; Indik, J.; Lee, R.; Mehra, M.R.; Menon, V.; Page, R.L.; Shen, W.K.; Slotwiner, D.J.; Warner Stevenson, L.; Varosy, P.D.; Welikovitch, L. HRS/ACC/AHA expert consensus statement on the use of implantable cardioverter-defibrillator therapy in patients who are not included or not well represented in clinical trials. Heart Rhythm, 2014, 11(7), 1270-1303.
[http://dx.doi.org/10.1016/j.hrthm.2014.03.041] [PMID: 24819194]
[11]
Priori, S.G.; Blomström-Lundqvist, C.; Mazzanti, A.; Blom, N.; Borggrefe, M.; Camm, J.; Elliott, P.M.; Fitzsimons, D.; Hatala, R.; Hindricks, G.; Kirchhof, P.; Kjeldsen, K.; Kuck, K.H.; Hernandez-Madrid, A.; Nikolaou, N.; Norekvål, T.M.; Spaulding, C.; Van Veldhuisen, D.J. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur. Heart J., 2015, 36(41), 2793-2867.
[http://dx.doi.org/10.1093/eurheartj/ehv316] [PMID: 26320108]
[12]
Aweimer, A.; Schiedat, F.; Schöne, D.; Landgrafe-Mende, G.; Bogossian, H.; Mügge, A.; Patsalis, P.C.; Gotzmann, M.; Akin, I.; El-Battrawy, I.; Dietrich, J.W. Abnormal cardiac repolarization in thyroid diseases: Results of an observational study. Front. Cardiovasc. Med., 2021, 8, 738517.
[http://dx.doi.org/10.3389/fcvm.2021.738517] [PMID: 34888359]
[13]
La Rovere, M.T.; Pinna, G.D.; Hohnloser, S.H.; Marcus, F.I.; Mortara, A.; Nohara, R.; Bigger, J.T., Jr; Camm, A.J.; Schwartz, P.J. Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: Implications for clinical trials. Circulation, 2001, 103(16), 2072-2077.
[http://dx.doi.org/10.1161/01.CIR.103.16.2072] [PMID: 11319197]
[14]
Moss, A.J.; Zareba, W.; Hall, W.J.; Klein, H.; Wilber, D.J.; Cannom, D.S.; Daubert, J.P.; Higgins, S.L.; Brown, M.W.; Andrews, M.L. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N. Engl. J. Med., 2002, 346(12), 877-883.
[http://dx.doi.org/10.1056/NEJMoa013474] [PMID: 11907286]
[15]
Gorgels, A.; Gijsbers, C.; de Vreede-Swagemakers, J.; Lousberg, A.; Wellens, H.J. Out-of-hospital cardiac arrest-the relevance of heart failure. Eur. Heart J., 2003, 24(13), 1204-1209.
[http://dx.doi.org/10.1016/S0195-668X(03)00191-X] [PMID: 12831814]
[16]
Kang, C. Badiceanu, A.; Brennan, J.A.; Gloschat, C.; Qiao, Y.; Trayanova, N.A.; Efimov, I.R. β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle. Sci. Rep., 2017, 7(1), 15922.
[http://dx.doi.org/10.1038/s41598-017-16218-3] [PMID: 29162896]
[17]
Akın, A.; Unal, E.; Yıldırım, R.; Ture, M.; Balık, H.; Haspolat, Y.K. Evaluation of QT dispersion and Tp‐e interval in children with subclinical hypothyroidism. Pacing Clin. Electrophysiol., 2018, 41(4), 372-375.
[http://dx.doi.org/10.1111/pace.13286] [PMID: 29369370]
[18]
Paschou, S.A.; Bletsa, E.; Stampouloglou, P.K.; Tsigkou, V.; Valatsou, A.; Stefanaki, K.; Kazakou, P.; Spartalis, M.; Spartalis, E.; Oikonomou, E.; Siasos, G. Thyroid disorders and cardiovascular manifestations: An update. Endocrine, 2022, 75(3), 672-683.
[http://dx.doi.org/10.1007/s12020-022-02982-4] [PMID: 35032315]

Rights & Permissions Print Cite
Article Metrics
12
1
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy