An Emerging Class of Antimicrobial Heterocycles Derived from Natural Sources

Title:An Emerging Class of Antimicrobial Heterocycles Derived from Natural Sources

Volume: 21 Issue: 13

Author(s): Benu Chaudhary*, Babita Patial, Rajiv Sharma and Anshul Chawla

Affiliation:

• Department of Pharmaceutical Sciences, CT University Ludhiana, Punjab, India
• Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India

Keywords: Antibiotics, heterocyclic compounds, antimicrobial activities, synergistic, natural, coumarin, proanthocyanidins, 4- thiazolidinone, alkaloids.

Abstract: An energetic desire to reduce the undesirable effects brought on by synthetic heterocyclic substances and to combat antimicrobial resistance has led to an increase in curiosity in using natural antimicrobial agents derived from plants, such as phenolics, catechol, pyrogallol, essential oils, Lchicoric acid, caffeic acid, catechins, coumarin, proanthocyanidins, 4-thiazolidinone, and alkaloids. The usage of naturally occurring heterocycles against Gram-positive (S. aureus, S. pyogenes, B. subtilis, A. niger, and B. cereus) and Gram-negative (P. aeruginosa, E. coli, K. pneumonia, P. vulgaris, and S. infantis) bacteria has been the subject of increased investigation in past few decades. This review targets the use of plant-derived antimicrobials to increase the microbiological safety of food and the possible antimicrobial activity of nitrogen- and oxygen-based heterocyclic compounds. It is possible to find novel medications to treat infectious diseases and address the issues brought on by antibiotic resistance by exploring and utilising the potential of these chemicals. Additional research is desirable on the toxicological effects and potential additive and/or synergistic antimicrobial actions in order to maximise the usage of these potential natural antimicrobials in foods.

Cite this article as:

Chaudhary Benu*, Patial Babita, Sharma Rajiv and Chawla Anshul, An Emerging Class of Antimicrobial Heterocycles Derived from Natural Sources, Letters in Drug Design & Discovery 2024; 21 (13) . https://dx.doi.org/10.2174/0115701808254524231018040600