An Emerging Class of Antimicrobial Heterocycles Derived from Natural Sources

Benu      Chaudhary; Babita      Patial; Rajiv      Sharma; Anshul      Chawla
doi:10.2174/0115701808254524231018040600
Abstract

An energetic desire to reduce the undesirable effects brought on by synthetic heterocyclic substances and to combat antimicrobial resistance has led to an increase in curiosity in using natural antimicrobial agents derived from plants, such as phenolics, catechol, pyrogallol, essential oils, Lchicoric acid, caffeic acid, catechins, coumarin, proanthocyanidins, 4-thiazolidinone, and alkaloids. The usage of naturally occurring heterocycles against Gram-positive (S. aureus, S. pyogenes, B. subtilis, A. niger, and B. cereus) and Gram-negative (P. aeruginosa, E. coli, K. pneumonia, P. vulgaris, and S. infantis) bacteria has been the subject of increased investigation in past few decades. This review targets the use of plant-derived antimicrobials to increase the microbiological safety of food and the possible antimicrobial activity of nitrogen- and oxygen-based heterocyclic compounds. It is possible to find novel medications to treat infectious diseases and address the issues brought on by antibiotic resistance by exploring and utilising the potential of these chemicals. Additional research is desirable on the toxicological effects and potential additive and/or synergistic antimicrobial actions in order to maximise the usage of these potential natural antimicrobials in foods.
Keywords: Antibiotics, heterocyclic compounds, antimicrobial activities, synergistic, natural, coumarin, proanthocyanidins, 4- thiazolidinone, alkaloids.
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DOI https://dx.doi.org/10.2174/0115701808254524231018040600	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X
Letters in Drug Design & Discovery

An Emerging Class of Antimicrobial Heterocycles Derived from Natural Sources

Abstract

Graphical Abstract
