Review Article

外泌体非编码RNA:黑色素瘤诊断和治疗策略的新途径

卷 31, 期 37, 2024

发表于: 24 October, 2023

页: [6084 - 6109] 页: 26

弟呕挨: 10.2174/0109298673267553231017053329

价格: $65

摘要

恶性黑色素瘤(MM)是一种预后不良的高度侵袭性癌症。目前,虽然有多种治疗黑色素瘤的方法,但由于肿瘤的复发、耐药性的出现、缺乏有效的治疗药物等诸多因素,MM仍然严重威胁着患者的生命。外泌体是具有生物活性的脂质双分子层细胞外囊泡,由多种细胞类型分泌,介导细胞间信号交流。研究发现外泌体通过携带多种生物活性分子参与癌症,包括非编码RNA (ncRNAs)。据报道,ncRNA在肿瘤的增殖、血管生成、免疫调节、侵袭、转移和治疗耐药等方面发挥重要作用。然而,外泌体ncRNA在MM中的功能作用仍然未知。因此,本文综述了黑色素瘤的诊断、治疗现状,以及外泌体ncRNAs在MM患者中的应用,以期为黑色素瘤进展机制提供新的认识,并作为诊断和治疗靶点的生物标志物。

关键词: 黑色素瘤,外泌体,非编码RNA,生物标志物,治疗靶点,脂质双分子层。

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