Review Article

丝氨酸蛋白酶抑制剂对丙型肝炎病毒的治疗干预

卷 31, 期 15, 2024

发表于: 19 October, 2023

页: [2052 - 2072] 页: 21

弟呕挨: 10.2174/0109298673234823230921090431

价格: $65

Open Access Journals Promotions 2
摘要

丙型肝炎病毒(HCV)是一种全球流行的危险疾病,可诱发几种持续性和潜在致命的肝脏疾病。目前的治疗策略提供有限的疗效,往往伴随着严重和衰弱的不良反应。因此,迫切需要开发新的治疗干预措施,以最大限度地发挥对抗HCV的功效,同时最大限度地减少患者的不良反应负担。抗HCV的一个有希望的靶点是NS3-4A丝氨酸蛋白酶,这是一种由两种HCV编码蛋白组成的复合物。这种非共价异二聚体在病毒生命周期中至关重要,已成为治疗干预的主要焦点。尽管聚乙二醇干扰素联合利巴韦林通常用于HCV治疗,但其疗效受到严重不良反应的影响,严重影响患者的生活质量。近年来,直接作用抗病毒药物(DAAs)的开发已成为HCV治疗的一个突破。这些药物对病毒表现出显著的效力,与其他DAA联合使用时,不良反应较少。然而,值得注意的是,由于NS3-4A蛋白酶氨基酸位置的改变,有可能对DAA产生耐药性。这强调需要进行持续的研究,以确定能够最大限度地减少耐药性的出现并确保长期有效性的战略。虽然DAA联合治疗HCV有希望,但考虑药物-药物相互作用的可能性至关重要。当同时使用不同的DAA时,可能会发生这些相互作用,从而潜在地损害其治疗效果。因此,仔细评估和监测潜在的药物相互作用对于优化治疗结果至关重要。在寻求新的HCV治疗干预措施的过程中,计算生物学和生物信息学领域已经成为一种有价值的工具。这些先进的技术和方法使开发和设计新药和治疗剂能够发挥最大的功效,降低耐药性风险,并将不良反应降到最低。通过利用计算方法,研究人员可以有效地筛选和优化潜在的候选药物,加速发现和开发高效的HCV治疗方法。

关键词: NS3-4A蛋白酶,聚乙二醇干扰素,利巴韦林,直接抗病毒药物,计算工具,丙型肝炎病毒。

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