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Review Article

LncRNA MEG3:靶向代谢性疾病的分子机制和致病原因

卷 31, 期 37, 2024

发表于: 19 October, 2023

页: [6140 - 6153] 页: 14

弟呕挨: 10.2174/0109298673268051231009075027

价格: $65

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摘要

背景：非编码RNA (Non-coding RNA)是一种不编码蛋白质的RNA，分布在rRNA、tRNA、snRNA、snoRNA、microRNA等具有鉴定功能的RNA中，其中长链非编码RNA (Long Non-coding RNA, lncRNA)的核苷酸长度在200以上。LncRNAs参与了人体多种生物过程，包括癌细胞的侵袭转移、细胞凋亡、细胞自噬、炎症等。近年来，越来越多的研究证实lncrna与肥胖及肥胖诱导的胰岛素抵抗和NAFLD存在关联，其中MEG3与葡萄糖代谢如胰岛素抵抗有关。此外，MEG3已被证明在多种癌症的病理过程中，如介导炎症、心血管疾病、肝脏疾病和其他代谢性疾病。 目的：探讨lncRNA MEG3在代谢性疾病中的调控作用。为临床治疗或实验研究提供了新的思路。 方法：为了获得足够的数据，本文对PubMed数据库中的数据进行了整合和分析。 结果：LncRNA MEG3可以调节多种代谢疾病，如胰岛素抵抗、NAFLD、炎症等。 结论：LncRNA MEG3在多种目前难以完全治愈的代谢性疾病中具有调控作用，MEG3是治疗这些疾病的潜在靶点。本文就lncRNA MEG3在人类代谢性疾病中的作用机制和生物学功能进行综述。

关键词: MEG3，长链非编码RNA，代谢性疾病，炎症，癌症，胰腺β细胞。

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