Abstract
In recent decades, the mortality and morbidity of Gastrointestinal (GI) cancer have remarkably increased, especially in younger individuals. Recent studies revealed that neuronal connections play an active part in GI tumor initiation and progression. Also, studies showed neurotransmitters and neuropeptides drive the activation of various oncogenic pathways downstream of neural receptors within cancer cells, underscoring the importance of neural signaling pathways in GI tumor malignancy. These studies show that the humoral and nervous pathways can transfer signals of tumors to the brain. But, the exact mechanism of this regulation from the brain to the gut is still unknown. In this review, we summarized the mechanism of the neuronal pathway in the regulation of promotion or suppression of GI cancer and oncogene activation, and we summarize recent findings linking the nervous system to GI tumor progression and highlight the importance of targeting neural mechanisms in GI tumor therapy
Keywords: Neural pathway, Gastrointestinal Cancers, prevention, GI, tumor therapy, humoral
Letters in Drug Design & Discovery
Title:The Role of Neuronal Pathways in Gastrointestinal Cancers: Targets for Prevention and Treatment
Volume: 21 Issue: 14
Author(s): Mohadeseh Poudineh, Samaneh Mollazadeh, Shima Mehrabadi, Majid Khazaei, Seyed Mahdi Hassanian and Amir Avan*
Affiliation:
- Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
- Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
- Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords: Neural pathway, Gastrointestinal Cancers, prevention, GI, tumor therapy, humoral
Abstract: In recent decades, the mortality and morbidity of Gastrointestinal (GI) cancer have remarkably increased, especially in younger individuals. Recent studies revealed that neuronal connections play an active part in GI tumor initiation and progression. Also, studies showed neurotransmitters and neuropeptides drive the activation of various oncogenic pathways downstream of neural receptors within cancer cells, underscoring the importance of neural signaling pathways in GI tumor malignancy. These studies show that the humoral and nervous pathways can transfer signals of tumors to the brain. But, the exact mechanism of this regulation from the brain to the gut is still unknown. In this review, we summarized the mechanism of the neuronal pathway in the regulation of promotion or suppression of GI cancer and oncogene activation, and we summarize recent findings linking the nervous system to GI tumor progression and highlight the importance of targeting neural mechanisms in GI tumor therapy
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Cite this article as:
Poudineh Mohadeseh, Mollazadeh Samaneh, Mehrabadi Shima, Khazaei Majid, Hassanian Mahdi Seyed and Avan Amir*, The Role of Neuronal Pathways in Gastrointestinal Cancers: Targets for Prevention and Treatment, Letters in Drug Design & Discovery 2024; 21 (14) . https://dx.doi.org/10.2174/0115701808258045231010102318
DOI https://dx.doi.org/10.2174/0115701808258045231010102318 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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