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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Recent Advances in the Synthesis and Analysis of Atorvastatin and its Intermediates

Author(s): Shu-Fang Li, Wei Zhang, Wen Zhang, An Huang, Jia-Qi Zhu, Ya-Jun Wang* and Yu-Guo Zheng

Volume 31, Issue 37, 2024

Published on: 11 October, 2023

Page: [6063 - 6083] Pages: 21

DOI: 10.2174/0109298673263728231004053704

Price: $65

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Abstract

Atorvastatin, a lipid-lowering drug that is widely used in the treatment of cardiovascular diseases, has significant clinical significance. This article focuses on the synthetic procedures of atorvastatin, including Paal-Knorr synthesis and several new synthetic strategies. It also outlines chemical and chemo-enzymatic methods for synthesizing optically active side chain of atorvastatin. In addition, a comprehensive overview of the analytical monitoring techniques for atorvastatin and its metabolites and impurities is reported, alongside a discussion of their strengths and limitations.

Keywords: Atorvastatin, lipid-lowering drug, HMG-CoA, statins, Paal-Knorr synthesis, analytical methods.

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