Title:A Review on the Use of Gold Nanoparticles in Cancer Treatment
Volume: 23
Issue: 20
Author(s): Razia Sultana, Dhananjay Yadav, Nidhi Puranik, Vishal Chavda, Jeongyeon Kim*Minseok Song*
Affiliation:
- Korea
Brain Research Institute (KBRI), Daegu, Republic of Korea
- Department of Life Sciences, Yeungnam University,
38541, Gyeongsan, Republic of Korea
Keywords:
Gold nanoparticles, photothermal therapy, photodynamic therapy, cancer therapy, immunotherapy, diagnosis.
Abstract: According to a 2020 WHO study, cancer is responsible for one in every six fatalities. One in four patients
die due to side effects and intolerance to chemotherapy, making it a leading cause of patient death. Compared
to traditional tumor therapy, emerging treatment methods, including immunotherapy, gene therapy, photothermal
therapy, and photodynamic therapy, have proven to be more effective. The aim of this review is to highlight
the role of gold nanoparticles in advanced cancer treatment. A systematic and extensive literature review
was conducted using the Web of Science, PubMed, EMBASE, Google Scholar, NCBI, and various websites.
Highly relevant literature from 141 references was chosen for inclusion in this review. Recently, the synergistic
benefits of nano therapy and cancer immunotherapy have been shown, which could allow earlier diagnosis, more
focused cancer treatment, and improved disease control. Compared to other nanoparticles, the physical and optical
characteristics of gold nanoparticles appear to have significantly greater effects on the target. It has a crucial
role in acting as a drug carrier, biomarker, anti-angiogenesis agent, diagnostic agent, radiosensitizer, cancer immunotherapy,
photodynamic therapy, and photothermal therapy. Gold nanoparticle-based cancer treatments can
greatly reduce current drug and chemotherapy dosages.