Title:The Impact of ABCB1 SNPs on Tacrolimus Pharmacokinetics in Liver or Kidney
Transplant Recipients: A Meta-analysis
Volume: 29
Issue: 29
Author(s): Ze Li, Xiaozhen Wang, Dandan Li, Sheng Cheng, Yiwen Dong, Hongge Yang and Xingang Li*
Affiliation:
- Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China
Keywords:
Liver, meta-analysis, ABCB1, SNPs, tacrolimus, pharmacokinetics, transplant recipients, kidney.
Abstract:
Purpose: We aimed to investigate the association between ATP Binding Cassette Subfamily B
Member 1 (ABCB1) single nucleotide polymorphisms (SNPs) and the pharmacokinetics of tacrolimus.
Methods: A search was conducted in Cochrane Central Register of Controlled Trials (CENTRAL), Web of
Science (SCI), MEDLINE, and Embase from inception to November 2022. Outcomes included weightadjusted
daily dose (DD) and dose-adjusted trough concentration (C0/Dose).
Results: A total of 1059 liver or kidney transplant recipients from 14 publications were included. For adult
liver transplantation recipients, DD of ABCB1 3435C>T CC carriers was 0.03 mg/kg/day (WMD = 0.03, 95%
CI: 0.01 to 0.05, I2 = 0%) higher than ABCB1 3435C>T T carriers at post-transplantation ≤ 7 days; C0/dose of
ABCB1 3435C>T CC carriers were 31.88 (WMD = -31.88, 95% CI: -62.32 to -1.45, I2 = 83.5%) or 34.61
(ng/ml)/(mg/kg/day) (WMD = -34.61, 95% CI: -65.26 to -3.97, I2 = 55.3%) lower than ABCB1 3435C>T T
carriers at post-transplantation ≤ 7 or 14 days, respectively. No difference in C0/dose was observed for
ABCB1 2677G>T/A or ABCB1 1236C>T SNPs in both liver and kidney transplant recipients.
Conclusion: ABCB1 3435C>T SNP might have a potential impact on tacrolimus pharmacokinetics in the early
stage after liver transplantation, indicating the probability of individualized immunosuppressive therapy
based on genetic polymorphism. Given some limitations, further well-designed prospective studies are warranted
to validate these conclusions..