Title:Recent Advancements in the Treatment of Alzheimer’s Disease: A Multitarget-directed Ligand Approach
Volume: 31
Issue: 37
Author(s): Sumit Kumar, Amol Mahajan, Ramesh Ambatwar and Gopal L. Khatik*
Affiliation:
- Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Raebareli, Uttar Pradesh, 226002, India
Keywords:
Neurodegenerative diseases, Alzheimer's disease, dementia, multitarget-directed ligands, brain, amyloid protein.
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease and one of the leading
causes of progressive dementia, affecting 50 million people worldwide. Many pathogenic
processes, including amyloid β aggregation, tau hyperphosphorylation, oxidative stress,
neuronal death, and deterioration of the function of cholinergic neurons, are associated
with its progression. The one-compound-one-target treatment paradigm was unsuccessful
in treating AD due to the multifaceted nature of Alzheimer's disease. The recent development
of multitarget-directed ligand research has been explored to target the complementary
pathways associated with the disease. We aimed to find the key role and progress of
MTDLs in treating AD; thus, we searched for the past ten years of literature on “Pub-
Med”, “ScienceDirect”, “ACS” and “Bentham Science” using the keywords neurodegenerative
diseases, Alzheimer’s disease, and multitarget-directed ligands. The literature was
further filtered based on the quality of work and relevance to AD. Thus, this review highlights
the current advancement and advantages of multitarget-directed ligands over traditional
single-targeted drugs and recent progress in their development to treat AD.