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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Protective Roles and Therapeutic Effects of Gallic Acid in the Treatment of Cardiovascular Diseases: Current Trends and Future Directions

Author(s): Zahra Momeni, Sepideh Danesh, Mahsa Ahmadpour, Reza Eshraghi, Tahereh Farkhondeh, Mohammad Hossein Pourhanifeh* and Saeed Samarghandian*

Volume 31, Issue 24, 2024

Published on: 05 October, 2023

Page: [3733 - 3751] Pages: 19

DOI: 10.2174/0109298673259299230921150030

Price: $65

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Abstract

Cardiovascular diseases (CVDs) are serious life-threatening illnesses and significant problematic issues for public health having a heavy economic burden on all society worldwide. The high incidence of these diseases as well as high mortality rates make them the leading causes of death and disability. Therefore, finding novel and more effective therapeutic methods is urgently required. Gallic acid, an herbal medicine with numerous biological properties, has been utilized in the treatment of various diseases for thousands of years. It has been demonstrated that gallic acid possesses pharmacological potential in regulating several molecular and cellular processes such as apoptosis and autophagy. Moreover, gallic acid has been investigated in the treatment of CVDs both in vivo and in vitro. Herein, we aimed to review the available evidence on the therapeutic application of gallic acid for CVDs including myocardial ischemia-reperfusion injury and infarction, drug-induced cardiotoxicity, hypertension, cardiac fibrosis, and heart failure, with a focus on underlying mechanisms.

Keywords: Gallic acid, cardiovascular diseases, myocardial infarction, hypertension, apoptosis, inflammation.

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