Title:Antimicrobial Bacterial Metabolites: Properties, Applications and Loading in
Liposomes for Site-specific Delivery
Volume: 29
Issue: 28
Author(s): Camilla A.S. Valença, Ana A.T. Barbosa, Silvio S. Dolabella, Patricia Severino, Carla Matos, Karolline Krambeck, Eliana B. Souto*Sona Jain*
Affiliation:
- UCIBIO - Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department
of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal;
- Associate Laboratory i4HB - Institute
for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal
- Post-Graduation Program in Industrial Biotechnology, University of Tiradentes, Aracaju, Sergipe, Brazil
Keywords:
Liposomes, antibiotic resistance, bacterial metabolites, bacterial bioactives, Bacillus species, antimicrobials.
Abstract: The high levels of antibiotic resistance registered worldwide have become a serious health problem,
threatening the currently available treatments for a series of infectious diseases. With antibiotics becoming less
and less effective, it is becoming increasingly difficult and, in some cases, impossible to treat patients with
even common infectious diseases, such as pneumonia. The inability to meet the ever-increasing demand to control
microbial infection requires both the search for new antimicrobials and improved site-specific delivery. On
the one hand, bacterial secondary metabolites are known for their diverse structure and antimicrobial potential
and have been in use for a very long time in diverse sectors. A good deal of research is produced annually describing
new molecules of bacterial origin with antimicrobial properties and varied applications. However, very
few of these new molecules reach the clinical phase and even fewer are launched in the market for use. In this
review article, we bring together information on these molecules with potential for application, in particular, for
human and veterinary medicine, and the potential added value of the use of liposomes as delivery systems for
site-specific delivery of these drugs with the synergistic effect to overcome the risk of antibiotic resistance.
