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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Mini-Review Article

Bdellovibrio bacteriovorus Therapy, an Emerging Alternative to Antibiotics

Author(s): Ibukun J. Abulude, Daniel E. Kadouri* and Xianwu Guo*

Volume 21, Issue 13, 2024

Published on: 19 September, 2023

Page: [2505 - 2520] Pages: 16

DOI: 10.2174/1570180820666230912161923

Price: $65

Open Access Journals Promotions 2
Abstract

The increase in multi-drug resistant (MDR) pathogens and the decline in the number of new antibiotics in the production pipeline pose a serious threat to our ability to treat infectious diseases. In this new landscape, once treatable diseases are now potentially life-threatening. This impending danger requires that urgent attention should be given to developing alternative strategies for combating MDR bacteria. A novel alternative is the use of predatory bacteria, B. bacteriovorus spp, that naturally prey on Gram-negative bacteria, including MDR Enterobacteriaceae. B. bacteriovorus has been shown to be nonpathogenic in animal models and on human cell lines, supporting its feasibility to be used to treat infections in animals and possibly humans. This document reviews various aspects of B. bacteriovorus biology, including its unique life cycle, "predatory toolbox", prey range, and recent research advances exploring B. bacteriovorus as an antimicrobial agent, stepping towards its use in human therapy. We also discuss the advantages and limitations of using B. bacteriovorus therapy and the strategies to overcome these limitations.

Keywords: Predatory bacteria, multi-drug resistance pathogen, antibiotic resistance, biotherapy, Bdellovibrio bacteriovorus, flagella.

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