Title:Nanosuspension: A Formulation Technology for Tackling the Poor Aqueous
Solubility and Bioavailability of Poorly Soluble Drugs
Volume: 29
Issue: 29
Author(s): Mohamed T. Elsebay*, Noura G. Eissa, Gehan F. Balata, Mohammad Amjad Kamal*Hanan M. Elnahas
Affiliation:
- Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Galala University, Suez, Egypt
- Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
- Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
- King Fahd Medical Research Center, King Abdulaziz University, Jeddah,
Saudi Arabia
- Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Birulia, Bangladesh
- Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia
- Novel Global Community Educational Foundation, Hebersham,
NSW 2770, Australia
Keywords:
Nanosuspension, solubility, BCS, polymers, bioavailability, pharmacokinetics.
Abstract: The poor water solubility of numerous novel drug candidates presents significant challenges, particularly
in terms of oral administration. This limitation can result in various undesirable clinical implications, such
as inter-patient variability, poor bioavailability, difficulties in achieving a safe therapeutic index, increased
costs, and potential risks of toxicity or inefficacy. Biopharmaceutics Classification System (BCS) class II drugs
face particular hurdles due to their limited solubility in the aqueous media of the gastrointestinal tract. In such
cases, parenteral administration is often employed as an alternative strategy. To address these challenges, nanosuspension
techniques offer a promising solution for enhancing drug solubility and overcoming oral delivery obstacles.
This technique has the potential to bridge the gap between drug discovery and preclinical use by resolving
problematic solubility. This literature review has delved into contemporary nanosuspension preparation
technologies and the incorporation of stabilizing ingredients within the formulation. Furthermore, the
manuscript explores nanosuspension strategies for both oral and parenteral/other delivery routes, and separate
discussions have been presented to establish a suitable flow that addresses the challenges and strategies relevant
to each administration method.