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Review Article

应对流感大流行的抗病毒化合物:2016-2022年的最新进展

卷 31, 期 18, 2024

发表于: 12 September, 2023

页: [2507 - 2549] 页: 43

弟呕挨: 10.2174/0929867331666230907093501

价格: $65

摘要

近几十年来，世界在新出现的呼吸道病毒引起的大流行事件的危险影响方面获得了经验。特别是，每年的流感流行造成严重疾病和死亡。即使传统流感疫苗是预防病毒感染的最有效工具，但它们对患有严重慢性疾病和免疫功能低下的患者并不完全有效，而且已经出现了新的小分子来预防和控制流感病毒。因此，化学家的注意力一直集中在合成新的抗病毒药物上，这些药物能够与参与病毒复制周期的不同分子靶点相互作用。迄今为止，利用几种合成策略，包括对目前使用的药物进行化学修饰，已经合成了能够靶向神经氨酸酶、血凝素蛋白、基质-2 (M2)蛋白离子通道、核蛋白或RNA依赖性RNA聚合酶的不同类型的流感病毒抑制剂。在抑制活性方面，最好的结果是在纳摩尔范围内，并且已经从临床使用的药物如帕拉米韦、扎那米韦、奥司他米尔、金刚乙胺以及唾液化分子和羟基吡啶酮衍生物的化学修饰中获得。本综述的目的是报告2016-2022年期间与合成有效流感病毒抑制剂相关的最新途径。

关键词: 抗病毒药物，流感病毒，神经氨酸酶，血凝素，核蛋白，膜蛋白，RNA聚合酶。

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