Login Register Cart 0
Generic placeholder image

Current Drug Discovery Technologies

Editor-in-Chief

ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Clinical Trial

The Effect of Aloe vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial

Author(s): Parichehr Sabaghzadeh Irani, Hadi Ranjbar, Roghayeh Mehdipour-Rabori*, Mahya Torkaman, Sudabeh Amirsalari and Farshid Alazmani-Noodeh

Volume 21, Issue 3, 2024

Published on: 08 September, 2023

Article ID: e040923220697 Pages: 8

DOI: 10.2174/1570163820666230904150945

Price: $65

conference banner
Abstract

Background: Diabetic foot ulcer (DFU) is a prevalent complication of diabetes that can result in severe consequences. The cost of treating DFUs is high, and there is a lack of new therapies available in developing countries. This has created a demand for complementary and alternative treatments. The objective of this study was to assess the impact of aloe vera gel on the healing process of diabetic foot ulcers.

Materials and Methods: The study was a double-blind, randomized, controlled clinical trial. The study samples were 66 patients with diabetic foot ulcers who were randomly assigned to two groups (intervention and control). All ulcers in both groups were washed with normal saline and dressed in sterile gauze. The ulcers in the intervention group were covered with a thin layer of Aloe Vera gel before the dressing. The Bates-Jensen Wound Assessment Tool (BWAT) was used on three occasions, including before the intervention period and at the end of each week. Data were analyzed using SPSS 16.

Results: After three weeks, there was a notable contrast in the recovery pattern of the two groups. The patients who had aloe vera gel added to their dressing showed a more substantial decrease in the mean scores of their BWAT.

Conclusion: These findings are promising and suggest that Aloe vera may be a safe and effective adjunctive treatment for diabetic foot ulcers. However, further research is needed to confirm these results and to investigate the underlying mechanisms of aloe vera's therapeutic effect on diabetic foot ulcers.

Keywords: Aloe vera, diabetic foot ulcer, wound, drug, complementary, trial.

Graphical Abstract

[1]
Won SH, Chung CY, Park MS, et al. Risk factors associated with amputation-free survival in patient with diabetic foot ulcers. Yonsei Med J 2014; 55(5): 1373-8.
[http://dx.doi.org/10.3349/ymj.2014.55.5.1373] [PMID: 25048499]
[2]
Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: A systematic review and meta-analysis. Ann Med 2017; 49(2): 106-16.
[http://dx.doi.org/10.1080/07853890.2016.1231932] [PMID: 27585063]
[3]
Joret MO, Osman K, Dean A, Cao C, van der Werf B. Multidisciplinary clinics reduce treatment costs and improve patient outcomes in diabetic foot disease. J Vasc Surg 2019; 70(3): 806-14.
[4]
Lavery LA, Davis KE, Berriman SJ, Braun L, Nichols A, Kim PJ, et al. WHS guidelines update: Diabetic foot ulcer treatment guidelines. Wound Repair Regen 2016; 70(3): 806-14.
[http://dx.doi.org/10.1111/wrr.12391]
[5]
Oguntibeju OO. Medicinal plants and their effects on diabetic wound healing. Vet World 2019; 12(5): 653-63.
[http://dx.doi.org/10.14202/vetworld.2019.653-663] [PMID: 31327900]
[6]
Yadav KH, Kumar JR, Basha SI, Deshmukh G, Gujjula R, Santhamma B. Wound healing activity of topical application of Aloe vera gel in experimental animal models. Int J Pharma Bio Sci 2012; 3(2): 63-72.
[7]
Liang J, Cui L, Li J, Guan S, Zhang K, Li J. Aloe vera: A medicinal plant used in skin wound healing. Tissue Eng Part B Rev 2020.
[PMID: 33066720]
[8]
Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med 2015; 5(1): 21-6.
[http://dx.doi.org/10.1016/j.jtcme.2014.10.006] [PMID: 26151005]
[9]
Daburkar M, Lohar V, Rathore A, Bhutada P, Tangadpaliwar S. An in vivo and in vitro investigation of the effect of Aloe vera gel ethanolic extract using animal model with diabetic foot ulcer. J Pharm Bioallied Sci 2014; 6(3): 205-12.
[http://dx.doi.org/10.4103/0975-7406.135248] [PMID: 25035641]
[10]
Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR. Topical application of Aloe vera accelerated wound healing, modeling, and remodeling: An experimental study. Ann Plast Surg 2016; 77(1): 37-46.
[http://dx.doi.org/10.1097/SAP.0000000000000239] [PMID: 25003428]
[11]
Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of Aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Iran J Med Sci 2019; 44(1): 1-9.
[PMID: 30666070]
[12]
Irani PS, Varaie S. Comparison of the effect of Aloe vera Gel and Nitrofurazone 2% on epithelialization and granulation tissue formation regarding superficial second-degree burns. Iran J Med Sci 2016; 41(3) (Suppl.): S3.
[PMID: 27840469]
[13]
Molazem Z, Mohseni F, Younesi M, Keshavarzi S. Aloe vera gel and cesarean wound healing: A randomized controlled clinical trial. Glob J Health Sci 2014; 7(1): 203-9.
[http://dx.doi.org/10.5539/gjhs.v7n1p203] [PMID: 25560349]
[14]
Ahmed M, Hussain F. Chemical composition and biochemical activity of Aloe vera (Aloe barbadensis Miller) leaves. Int J Chem Biochem Sci 2013; 3: 29-33.
[15]
Benson KF, Newman RA, Jensen GS. Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (nae-8(®)) Clin Cosmet Investig Dermatol 2015; 8: 239-48.
[PMID: 26005354]
[16]
Liu C, Cui Y, Pi F, Cheng Y, Guo Y, Qian H. Extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, a polysaccharide from aloe vera: A review. Molecules 2019; 24(8): 1554.
[http://dx.doi.org/10.3390/molecules24081554] [PMID: 31010204]
[17]
Teplicki E, Ma Q, Castillo DE, et al. The effects of aloe vera on wound healing in cell proliferation, migration, and viability. Wounds 2018; 30(9): 263-8.
[PMID: 30256753]
[18]
Haque SD, Saha SK, Salma U, Nishi MK, Rahaman MS. Antibacterial effect of aloe vera (Aloe barbadensis) leaf gel against Staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and klebsiella pneumoniae. Mymensingh Med J 2019; 28(3): 490-6.
[PMID: 31391416]
[19]
Sabaghzadeh Irani P, Ranjbar H, Varaei S, Bostani S, Akbari O, Askarymahani M. Comparison of the effectiveness of Aloe Vera Gel with 2% Nitrofurazone ointment on the healing of superficial partial-thickness burns: A randomized clinical trial study. Nursing Practice Today 2022; 9(1): X-X.
[20]
Harris C, Bates-Jensen B, Parslow N, Raizman R, Singh M, Ketchen R. Bates-Jensen wound assessment tool: Pictorial guide validation project. J Wound Ostomy Continence Nurs 2010; 37(3): 253-9.
[http://dx.doi.org/10.1097/WON.0b013e3181d73aab] [PMID: 20386331]
[21]
Alves DFS, Almeida AO, Silva JLG, Morais FI, Dantas SRPE, Alexandre NMC. Translation and adaptation of the Bates-Jensen wound assessment tool for the Brazilian culture. Texto Contexto Enferm 2015; 24(3): 826-33.
[http://dx.doi.org/10.1590/0104-07072015001990014]
[22]
Ghaffarzadegan R, Alizadeh SA, Ghaffarzadegan R, Haji Agaei R, Ahmadlou M. Effect of aloe vera gel, compared to 1% silver sulfadiazine cream on second-degree burn wound healing. J Complement 2013; 3(1): 418-28.
[23]
Greenhalgh DG, Saffle JR, Holmes JH, Gamelli RL, et al. American burn association consensus conference to define sepsis and infection in burns. J Burn Care Res 2007; 28(6): 776-90.
[24]
Aqsa T, Shafique MS, Qureshi U. Efficacy of Aloe vera cream for healing diabetic foot ulcers. J Rawalpindi Med 2019; 23(2): 113-5.
[25]
Dat AD, Poon F, Pham KBT, Doust J. Aloe vera for treating acute and chronic wounds. Sao Paulo Med J 2014; 132(6): 382.
[http://dx.doi.org/10.1590/1516-3180.20141326T1] [PMID: 25351761]
[26]
Sari Y, Purnawan I, Kurniawan DW, Sutrisna E. A comparative study of the effects of nigella sativa oil gel and aloe vera gel on wound healing in diabetic rats. J Evid-Based Integr Med 2018; 23: 2515690X18772804.
[http://dx.doi.org/10.1177/2515690X18772804]
[27]
Avijgan M, Avijgan M, Hakamifard A, Razavi N. An innovation for retarded healing process of a chronic ulcer by aloe vera gel treatment. J Nat Rem 2016; 16(2): 45-51.
[http://dx.doi.org/10.18311/jnr/2016/479]
[28]
Panahi Y, Izadi M, Sayyadi N, Rezaee R, Jonaidi-Jafari N, Beiraghdar F, et al. Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds. J Wound Care 2015; 24(10): 459-60.
[29]
Tottoli EM, Dorati R, Genta I, Chiesa E, Pisani S, Conti B. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics 2020; 12(8): 735.
[http://dx.doi.org/10.3390/pharmaceutics12080735]
[30]
Hashemi SA, Madani SA, Abediankenari S. The review on properties of Aloe vera in healing of cutaneous wounds. Biomed Res Int 2015; 2015: 714216.
[http://dx.doi.org/10.1155/2015/714216]
[31]
Farzadinia P, Jofreh N, Khatamsaz S, et al. Anti-inflammatory and wound healing activities of Aloe vera, honey and milk ointment on second-degree burns in rats. Int J Low Extrem Wounds 2016; 15(3): 241-7.
[http://dx.doi.org/10.1177/1534734616645031] [PMID: 27217089]
[32]
Xing W, Guo W, Zou CH, et al. Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. J Dermatol Sci 2015; 79(2): 101-9.
[http://dx.doi.org/10.1016/j.jdermsci.2015.03.016] [PMID: 26049685]
[33]
Barkat MA. Harshita, Pottoo FH, Singh SP, Ahmad FJ. Therapeutic intervention of Aloe gel containing nano-sized and Micron-sized silver sulfadiazine gel on second-degree burn: A comparative study. Int J Low Extrem Wounds 2018; 17(3): 176-83.
[http://dx.doi.org/10.1177/1534734618791860] [PMID: 30111204]
[34]
Desjardins-Park HE, Foster DS, Longaker MT. Fibroblasts and wound healing: An update. Regen Med 2018; 13(5): 491-5.
[35]
Hobson R. Vitamin E and wound healing: An evidence-based review. Int Wound J 2016; 13(3): 331-5.
[http://dx.doi.org/10.1111/iwj.12295] [PMID: 25124164]
[36]
Najafian Y, Khorasani ZM, Najafi MN, Hamedi SS, Mahjour M, Feyzabadi Z. Efficacy of aloe vera/plantago major gel in diabetic foot ulcer: A randomized double-blind clinical trial. Curr Drug Discov Technol 2019; 16(2): 223-31.
[http://dx.doi.org/10.2174/1570163815666180115093007] [PMID: 29336265]
[37]
Bahar A, Saeedi M, Kashi Z, Akha O, Rabiei K, Davoodi M. The effect of aleo vera and honey gel in healing diabetic foot ulcers. J Mazandaran Univ Med Sci 2015; 25(128): 113-7.
[38]
Burusapat C, Supawan M, Pruksapong C, Pitiseree A, Suwantemee C. Topical Aloe vera gel for accelerated wound healing of split-thickness skin graft donor sites: A double-blind, randomized, controlled trial and systematic review. Plast Reconstr Surg 2018; 142(1): 217-26.
[http://dx.doi.org/10.1097/PRS.0000000000004515] [PMID: 29649056]

Rights & Permissions Print Cite
Article Metrics
24
2
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy