Title:Macrophage-targeted Nanomedicine for Sepsis: Diagnosis and Therapy
Volume: 29
Issue: 26
Author(s): Liyuan Yang, Xiaoli Lou, Shanshan Hao, Li Zhou and Yanqiang Hou*
Affiliation:
- Department of Clinical Laboratory, School of Medicine (Preparatory Stage), Songjiang Hospital Affiliation to Shanghai Jiao Tong
University, Shanghai 201600, China
Keywords:
Sepsis, macrophage, nanoparticle, diagnoses, nanomedicine, pathophysiological and biochemical dysregulation.
Abstract: Sepsis is a syndrome involving complex pathophysiological and biochemical dysregulation. Nanotechnology
can improve our understanding of the pathophysiology of sepsis and contribute to the development
of novel diagnostic and therapeutic strategies to further reduce the risk of sepsis. Macrophages play a key role
in the progression of sepsis, thus, macrophage-associated pathological processes are important targets for both
diagnostic and treatment of sepsis. In this paper, we reviewed efforts in the past decade of nanotechnologybased
solutions for manipulate macrophages in sepsis diagnosis and management according to the type of nanomaterial.
We addressed the latest progress of nanoparticles targeting macrophages for early sepsis detection.
Additionally, we summarized the unique advantages of macrophage-targeted nanoparticles in the treatment of
sepsis. These nanoparticles can improve the dysregulation of inflammatory response in sepsis by inhibiting the
release of inflammatory factors and regulating macrophage apoptosis, activity and polarization. Finally, we present
future opportunities as well as challenges of novel diagnostic and therapeutic strategies with the aim of accelerating
the clinical translation of nanomedicine for sepsis treatment.
