The Synthesis and Pharmacological Activity of Ursolic Acid Derivatives Modified at C-28 and C-3 Sites

Title:The Synthesis and Pharmacological Activity of Ursolic Acid Derivatives Modified at C-28 and C-3 Sites

Volume: 21 Issue: 14

Author(s): Jiawen Deng, Si Zhang, Yan Tan, Jing Zou, Meiling Liu, Zehua Yang, Xu Yao*, Pengbing Mi*Xing Zheng*

Affiliation:

• University of South China Institute of Pharmacy and Pharmacology Hengyang China

• University of South China Institute of Pharmacy and Pharmacology Hengyang China

• University of South China Institute of Pharmacy and Pharmacology Hengyang China

Keywords: Pharmacological activity, synthesis, triterpenoid compounds, ursolic acid derivatives, triterpenes.

Abstract: Ursolic acid (UA) is a widely distributed triterpenoid in nature. Due to its easy availability and multiple pharmacological activities, ursolic acid has attracted much attention in the field of medicine and pharmacology. To overcome the disadvantages of bioavailability and poor water solubility during the ursolic acid application, we focused on the synthetic and medicinal properties of UA derivatives modified at C-3 and C-28 sites. This review presents the synthesis of UA derivatives with modification at C-3 and C-28 sites and their pharmacological activity, which may provide some important information for further research and development of UA-based drugs.

Cite this article as:

Deng Jiawen, Zhang Si, Tan Yan, Zou Jing, Liu Meiling, Yang Zehua, Yao Xu*, Mi Pengbing*, Zheng Xing*, The Synthesis and Pharmacological Activity of Ursolic Acid Derivatives Modified at C-28 and C-3 Sites, Letters in Drug Design & Discovery 2024; 21 (14) . https://dx.doi.org/10.2174/1570180820666230823093545