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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Online): 2212-3873

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Review Article

Ethnomedicinal Importance of Patuletin in Medicine: Pharmacological Activities and Analytical Aspects

Author(s): Dinesh Kumar Patel*, Gireesh Kumar Singh, Gulam Mohammed Husain and Satyendra K. Prasad

Volume 24, Issue 5, 2024

Published on: 04 October, 2023

Page: [519 - 530] Pages: 12

DOI: 10.2174/1871530323666230816141740

Price: $65

Abstract

Background: Plant-derived bioactive molecules have been a major source of therapeutic agents for human and veterinarian purposes. Different traditional medicine system across the globe had relied on natural resources to meet their demand of healthcare. Still in modern world, pharmaceutical industries look for phytochemicals to develop new drugs. The current review explores patuletin, a flavonoid for its diverse reported pharmacological activities along with its analytical techniques.

Methods: Scientific data published on patuletin was collected from Scopus, Science Direct, Pubmed, Google, and Google Scholar. The collected data were analyzed and arranged as per specific pharmacological activities performed using in-vitro or in-vivo methods. Analytical methods of patuletin have been presented next to pharmacological activities

Results: Available scientific literature indicates patuletin has anti-inflammatory, cytotoxic, genotoxic, hepatoprotective, antiproliferative, antiplatelet, antinociceptive, and antioxidant activity. In addition to these activities, its biological potential on breast cancer, rheumatoid arthritis, aldose reductase, and different types of microorganisms has been also presented in this work. Analytical data on patuletin signified the importance of patuletin for the standardization of herbal products and derived medicine.

Conclusion: It may be concluded that patuletin with its diverse biological activities and readily available analytical methods, holds the potential to be translated into a new drug entity.

Keywords: Patuletin, anti-inflammatory, cytotoxic, hepatoprotective, antiproliferative, antiplatelet, antinociceptive, antioxidant, breast cancer, rheumatoid arthritis, aldose reductase.

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