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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Medicinal Plant-derived Phytochemicals in Detoxification

Author(s): Geir Bjørklund*, Natália Cruz-Martins, Bey Hing Goh, Olha Mykhailenko, Roman Lysiuk, Mariia Shanaida, Larysa Lenchyk, Taras Upyr, Marius Emil Rusu, Antonina Pryshlyak, Volodymyr Shanaida and Salvatore Chirumbolo

Volume 30, Issue 13, 2024

Published on: 12 September, 2023

Page: [988 - 1015] Pages: 28

DOI: 10.2174/1381612829666230809094242

Price: $65

Abstract

The average worldwide human life expectancy is 70 years, with a significantly higher value in Western societies. Many modern diseases are not associated with premature mortality but with a decreased quality of life in aged patients and an excessive accumulation of various toxic compounds in the human body during life. Today, scientists are especially interested in finding compounds that can help increase a healthy lifespan by detoxifying the body. Phytotherapy with specific approaches is used in alternative medicine to remove toxins from the body. Worldwide, research is conducted to identify medicinal plant-derived molecules that, with few or no side effects, may protect the liver and other organs. This review provides updated information about the detoxification process, the traditional and modern use of the most effective medicinal plants, their active metabolites as detoxifying agents, and the mechanisms and pathways involved in the detoxification process. Among medicinal plants with substantial detoxifying properties, a major part belongs to the Asteraceae family (Silybum marianum, Cynara scolymus, Arctium lappa, Helichrysum species, Inula helenium, and Taraxacum officinale). The most widely used hepatoprotective phytocomponent is silymarin, a standardized extract from the Silybum marianum seeds containing a mixture of flavonolignans. Many polysaccharides, polyphenols, and terpenoids have a detoxifying effect. Overall, scientific data on medicinal plants used in phytotherapeutic practice worldwide provides an understanding and awareness of their efficacy in detoxification.

Keywords: Medicinal plants, bioactive natural compounds, phytotherapy, detoxifying agents, hepatoprotection, mechanisms of action.

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