Synthetic and Pharmacological Expedition of Pyrazolo[1,5-a]pyridine: A
Comprehensive Review

Neetu      Agrawal; Dimple      Bansal; Vertika      Gautam
doi:10.2174/1570180820666230803101948
Abstract

Fused nitrogen-containing heterocyclic compounds have been identified to display a prominent role in medicinal chemistry, biochemistry, and other streams of science. Countless derivatives of pyrazolo[ 1,5-a] pyridine have been investigated by researchers for their distinct pharmacological characterization. In this article, we have revealed and arranged the various routes of synthesis and therapeutic activities such as dopamine binding affinity, kinase inhibitory activity, and PDE inhibitors of pyrazolo[1,5- a]pyridine-containing compounds which have been explored till now. The remarkable outcomes obtained via in vitro as well as in vivo profile screening of this moiety and its derivatives lead this scaffold to be recognized to a greater extent and examined further for better results. This review will give medicinal chemists a flying-bird eye catch view of pyrazolo[1,5-a] pyridine derivatives which will help them to design and synthesize potential compounds bearing this moiety.
Keywords: Pyrazolo[1, 5-a] pyridine, synthetic methods, kinase inhibitor, PDE inhibitor, dopamine affinity, biological activities.
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DOI https://dx.doi.org/10.2174/1570180820666230803101948	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X
Letters in Drug Design & Discovery

Synthetic and Pharmacological Expedition of Pyrazolo[1,5-a]pyridine: A Comprehensive Review

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