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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Anti-gout and Urate-lowering Potentials of Curcumin: A Review from Bench to Beside

Author(s): Amir Masoud Jafari-Nozad, Amirsajad Jafari, Saman Yousefi, Hasan Bakhshi, Tahereh Farkhondeh* and Saeed Samarghandian*

Volume 31, Issue 24, 2024

Published on: 04 October, 2023

Page: [3715 - 3732] Pages: 18

DOI: 10.2174/0929867331666230721154653

Price: $65

Abstract

Background: Gouty arthritis is a complex form of inflammatory arthritis, triggered by the sedimentation of monosodium urate crystals in periarticular tissues, synovial joints, and other sites in the body. Curcumin is a natural polyphenol compound, isolated from the rhizome of the plant Curcuma longa, possessing countless physiological features, including antioxidant, anti-inflammatory, and anti-rheumatic qualities.

Objective: This study aimed to discuss the beneficial impacts of curcumin and its mechanism in treating gout disease.

Methods: Ten English and Persian databases were used to conduct a thorough literature search. Studies examining the anti-gouty arthritis effects of curcumin and meeting the inclusion criteria were included.

Results: According to the studies, curcumin has shown xanthine oxidase and urate transporter- 1 inhibitory properties, uric acid inhibitory characteristics, and antioxidant and anti- inflammatory effects. However, some articles found no prominent reduction in uric acid levels.

Conclusion: In this review, we emphasized the potency of curcumin and its compounds against gouty arthritis. Despite the potency, we suggest an additional well-designed evaluation of curcumin, before its therapeutic effectiveness is completely approved as an antigouty arthritis agent.

Keywords: Arthritis, joint diseases, curcumin, gout, uric acid, Curcuma longa.

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