Title:Kaempferol: A Dietary Flavonol in Alleviating Obesity
Volume: 29
Issue: 20
Author(s): Hamid Reza Nejabati*, Sadeneh Nikzad and Leila Roshangar
Affiliation:
- Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords:
Obesity, kaempferol, flavonol, lifestyle, diet exercise, dietary.
Abstract: Obesity is considered as a chronic and high-prevalence disease on a global scale which affects all
genders and ages. Although various drugs have been confirmed for the treatment of obesity, these medications
have been shown to have a number of adverse effects on health. It is highlighted that natural products have an
alleviative role in a broad spectrum of diseases, in particular obesity, and diabetes. Kaempferol (KMP), a plant-
derived flavonol, is considerably engaged in the suppression of oxidative stress, radical scavenging, opposing
cellular toxicity, and induction of the production and release of growth factors. This flavonol combats obesity
by suppressing adipogenesis, regulating lipid and glucose metabolism, changing gut microbiota, and activating
autophagy. Also, studies have shown that KMP exerts its anti-obesity actions by decreasing the accumulation
of lipids and triglycerides (TGs), increasing fatty acid oxidation, and regulating multiple metabolic genes in the
adipocytes. Considering that KMP may be a potential candidate for combating obesity, this paper summarizes
the possible therapeutic roles of KMP in the treatment and prevention of this disease.