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Review Article

衰老与糖尿病肾病:新出现的发病机制和临床意义

卷 31, 期 6, 2024

发表于: 14 July, 2023

页: [697 - 725] 页: 29

弟呕挨: 10.2174/0929867330666230621112215

价格: $65

Open Access Journals Promotions 2
摘要

糖尿病肾病(DKD)是世界范围内慢性肾病(CKD)和终末期肾病(ESRD)的主要原因之一。随着老龄化势不可挡的趋势，DKD在老年人中的患病率逐渐增加。遗传因素、糖代谢异常、炎症、线粒体失调和氧化应激都有助于DKD的发展。可以想象，随着年龄的增长，这些病理生物学过程可能会加强，这将进一步加剧老年患者肾功能的恶化，最终导致ESRD。目前，老年人DKD的发病机制还不是很清楚。本研究对糖尿病肾病与衰老的关系进行了评估，同时讨论了老年肾脏的结构和功能变化，相关机制对DKD结果的影响，以及靶向治疗的最新进展。

关键词: 衰老，糖尿病肾病，发病机制，病理，ESRD, DKD。

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