Title:Electrochemical Label-free Methods for Ultrasensitive Multiplex
Protein Profiling of Infectious Diseases
Volume: 31
Issue: 25
Author(s): Sasya Madhurantakam, Nathan Kodjo Mintah Churcher, Ruchita Mahesh Kumar and Shalini Prasad*
Affiliation:
- Department of Bioengineering, The University of Texas at Dallas, 75080, USA
Keywords:
Infectious diseases, electrochemical, biomarkers, diagnosis, biosensors, label-free.
Abstract: Electrochemical detection methods are the more appropriate detection methods
when it comes to the sensitive and specific determination of biomarkers. Biomarkers
are the biological targets for disease diagnosis and monitoring. This review focuses on recent
advances in label-free detection of biomarkers for infectious disease diagnosis. The
current state of the art for rapid detection of infectious diseases and their clinical applications
and challenges were discussed. Label-free electroanalytical methods are probably
the most promising means to achieve this. We are currently in the early stages of the
emerging technology of using label-free electrochemistry of proteins to develop biosensors.
To date, antibody-based biosensors have been intensively developed, although
many improvements in reproducibility and sensitivity are still needed. Moreover, there is
no doubt that a growing number of aptamers and hopefully label-free biosensors based
on nanomaterials will soon be used for disease diagnosis and therapy monitoring. And also
here in this review article, we have discussed recent developments in the diagnosis of
bacterial and viral infections, as well as the current status of the use of label-free electrochemical
methods for monitoring inflammatory diseases.
