Title:Administration of Inhibitory Molecules through Nanoparticles in
Breast Cancer Therapy
Volume: 31
Issue: 6
Author(s): Christian Rafael Quijia*, Andreina Quevedo Enríquez, Carlos Daniel Zappia, Roxana Noemí Peroni and Marlus Chorilli*
Affiliation:
- Department of Drugs and Medicines, School of Pharmaceutical Sciences of São Paulo State University
(UNESP), Rodovia Araraquara Jau, Km 01 – s/n – Campos Ville, 14800-903 Araraquara, Sao Paulo, Brazil
- Department of Drugs and Medicines, School of Pharmaceutical Sciences of São Paulo State University
(UNESP), Rodovia Araraquara Jau, Km 01 – s/n – Campos Ville, 14800-903 Araraquara, Sao Paulo, Brazil
Keywords:
Nanoparticle, delivery, drugs, inhibitory molecules, breast cancer, nanosystem.
Abstract: According to Global Cancer Statistics, breast cancer is the second leading cause
of mortality in women. While there are several treatments for breast cancer, they are not always
effective. In most cases, after initial treatment, patients may present a low response to
therapy, more severe relapses, and even drug resistance. Hence, more effective and targeted
therapies are needed. Recently, the use of nanoparticles has emerged as a promising alternative
that will allow the controlled release of drugs in response to stimuli, precise delivery to
the site of action, lower levels of toxicity, and fewer side effects. In this review, we provide
an overview of the recent evidence proposing the delivery of inhibitory molecules encapsulated
in nanoparticles as a new therapy for breast cancer that targets the signaling pathways
governing the processes of tumor formation, maintenance, and expansion.
