Title:Polyphenolic Nano-formulations: A New Avenue against Bacterial Infection
Volume: 31
Issue: 37
Author(s): Faegheh Farhadi, Samira Eghbali, Sousan Torabi Parizi, Tannaz Jamialahmadi, Eric Gumpricht and Amirhossein Sahebkar*
Affiliation:
- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad,
Iran
- Biotechnology Research Center, Pharmaceutical
Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
- Department of Biotechnology,
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
Antibacterial, nano metal, nanoformulation, natural products, polyphenols, synergistic effects, ROS generation.
Abstract: The gradual emergence of new bacterial strains impervious to one or more antibiotics
necessitates discovering and applying natural alternatives. Among natural products,
various polyphenols exhibit antibacterial activity. However, polyphenols with biocompatible
and potent antibacterial characteristics are limited due to low aqueous solubility
and bioavailability; therefore, recent studies are considering new polyphenol formulations.
Nanoformulations of polyphenols, especially metal nanoparticles, are currently being
investigated for their potential antibacterial activity. Nanonization of such products increases
their solubility and helps attain a high surface-to-volume ratio and, therefore, a
higher reactivity of the nanonized products with better remedial potential than nonnanonized
products. Polyphenolic compounds with catechol and pyrogallol moieties efficiently
bond with many metal ions, especially Au and Ag. These synergistic effects exhibit
antibacterial pro-oxidant ROS generation, membrane damage, and biofilm eradication.
This review discusses various nano-delivery systems for considering polyphenols as antibacterial
agents.