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Review Article

Nrf2信号在铅致毒性中的作用

卷 31, 期 23, 2024

发表于: 12 July, 2023

页: [3529 - 3549] 页: 21

弟呕挨: 10.2174/0929867330666230522143341

价格: $65

摘要

核因子红系2相关因子2 (Nuclear factor erythroid 2-related factor 2, Nrf2)调节细胞抗氧化能力，是多种病理过程的主要保护因子之一。一些研究广泛探讨了环境暴露于重金属，特别是铅(Pb)与各种人类疾病发展之间的关系。据报道，这些金属能够直接或间接地诱导活性氧(ROS)的产生，并引起各器官的氧化应激。由于Nrf2信号在维持氧化还原状态中很重要，因此根据特定的生物学背景，它具有双重作用。一方面，Nrf2提供了抗金属诱导毒性的保护机制;另一方面，经长时间接触和激活，可诱发金属致癌。因此，本文旨在总结有关有毒金属(如Pb和Nrf2信号传导)之间功能相互关系的最新知识。

关键词: Nrf2通路，铅，铅，氧化应激，致癌作用，毒性。

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