Title:Moxifloxacin: Physical-chemical and Microbiological Analytical Methods in the
Context of Green Analytical Chemistry
Volume: 29
Issue: 15
Author(s): Thaisa Alves Celedonio da Silva, Isadora Alves Lustosa and Ana Carolina Kogawa*
Affiliation:
- Department of Pharmacy, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil
Keywords:
Moxifloxacin, analytical methods, green analytical chemistry, pharmaceutical, biological matrices, fluoroquinolone.
Abstract: Moxifloxacin (MOX) is a fourth-generation fluoroquinolone used in the form of tablets, infusion solutions
and ophthalmic solutions. It does not have a physical-chemical or microbiological analytical method described
in an official compendium. However, the literature shows some analysis methods for pharmaceuticals
and biological matrices. In this context, the objective is to show the analytical methods present in the literature
for the investigation of MOX by physical-chemical and microbiological techniques, as well as discussing them
according to the requirements of current pharmaceutical analyses and green analytical chemistry. Among the
physical-chemical methods present in the literature for MOX evaluation, 33% are HPLC, 21% are UV-Vis and
17% are capillary electrophoresis. On the other hand, among the microbiological methods, all of them are based
on diffusion in agar. There is still scope in the literature to incorporate new and improved analytical methods
for MOX evaluation, which adopt the concepts of green and sustainable analytical chemistry, either by using
less (or not using) toxic organic solvents, reducing waste generation or even reducing the analysis time according
to the intended objectives.
