Title:The Chemoprotective Potentials of Alpha-lipoic Acid against
Cisplatin-induced Ototoxicity: A Systematic Review
Volume: 31
Issue: 23
关键词:
癌症，顺铂，化疗，耳毒性，α -硫辛酸，生化参数。
摘要:
Purpose: Ototoxicity is one of the major adverse effects of cisplatin therapy which restrict
its clinical application. Alpha-lipoic acid administration may mitigate cisplatin-induced ototoxicity.
In the present study, we reviewed the protective potentials of alpha-lipoic acid against the
cisplatin-mediated ototoxic adverse effects.
Methods: Based on the PRISMA guideline, we performed a systematic search for the identification
of all relevant studies in various electronic databases up to June 2022. According to the inclusion
and exclusion criteria, the obtained articles (n=59) were screened and 13 eligible articles were finally
included in the present study.
Results: The findings of in-vitro experiments showed that cisplatin treatment significantly reduced
the auditory cell viability in comparison with the control group; nevertheless, the alpha-lipoic acid
co-administration protected the cells against the reduction of cell viability induced by cisplatin
treatment. Moreover, the in-vivo results of the auditory brainstem response (ABR) and distortion
product otoacoustic emission (DPOAE) tests revealed a decrease in DPOAE and an increase in
ABR threshold of cisplatin-injected animals; however, it was shown that alpha-lipoic acid co-treatment
had an opposite pattern on the evaluated parameters. Other findings demonstrated that cisplatin
treatment could significantly induce the biochemical and histopathological alterations in inner
ear cells/tissue; in contrast, alpha-lipoic acid co-treatment ameliorated the cisplatin-mediated biochemical
and histological changes.
Conclusion: The findings of audiometry, biochemical parameters, and histological evaluation
showed that alpha-lipoic acid co-administration alleviates the cisplatin-induced ototoxicity. The
protective role of alpha-lipoic acid against the cisplatin-induced ototoxicity can be due to different
mechanisms of anti-oxidant, anti-apoptotic, anti-inflammatory activities, and regulation of cell cycle
progression.
