Title:Recent Updates on Interaction Studies and Drug Delivery of
Antimalarials with Serum Albumin Proteins
Volume: 31
Issue: 25
Author(s): Kashish Azeem, Iram Irfan, Qudsia Rashid, Shailja Singh, Rajan Patel*Mohammad Abid*
Affiliation:
- Biophysical Chemistry Laboratory, Centre for Interdisciplinary Research in Basic Sciences,
Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
- Medicinal Chemistry Laboratory, Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi
110025, India
Keywords:
Antimalarials, serum albumin, binding affinity, spectroscopy, pharmacology, actual drug efficacy.
Abstract: This review focuses on recent trends in the binding study of various antimalarial
agents with serum albumins in detail. Serum albumin has a significant role in the
transport of drugs and endogenous ligands. The nature and magnitude of serum albumin
and drug interactions have a tremendous impact on the pharmacological behavior and toxicity
of that drug. Binding of drug to serum albumin not only controls its free and active
concentration, but also provides a reservoir for a long duration of action. This ultimately
affects drug absorption, distribution, metabolism, and excretion. Such interaction determines
the actual drug efficacy as the drug action can be correlated with the amount of unbound
drug. With the advancement in spectroscopic techniques and simulation studies,
binding studies play an increasingly important role in biophysical and biomedical science,
especially in the field of drug delivery and development. This review assesses the insight
we have gained so far to improve drug delivery and discovery of antimalarials on the basis
of a plethora of drug-serum protein interaction studies done so far.