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Review Article

疫苗接种后免疫细胞的代谢重编程：从代谢产物到个体化疫苗学

卷 31, 期 9, 2024

发表于: 26 June, 2023

页: [1046 - 1068] 页: 23

弟呕挨: 10.2174/0929867330666230509110108

价格: $65

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摘要

识别由对疫苗的免疫反应诱导的代谢特征可以区分接种疫苗的受试者和未接种疫苗的人，并破译与宿主免疫反应相关的分子机制。这篇综述阐述并讨论了基于代谢组学的对疫苗的先天和适应性免疫反应、长期功能重编程（免疫记忆）和不良反应的研究结果。疫苗不会过度表达糖酵解，这表明免疫细胞对疫苗的反应在感染期间不需要快速的能量供应。疫苗强烈影响脂质代谢，包括饱和或不饱和脂肪酸、磷酸肌醇和胆固醇。胆固醇在活化的巨噬细胞和树突状细胞中合成25-羟基胆固醇具有策略性，并分别刺激M2巨噬细胞和Treg中巨噬细胞和T细胞的转化。总之，代谢组学的大规模应用使得能够识别疫苗有效性/耐受性的候选预测生物标志物。

关键词: 代谢组学，疫苗，代谢重编程，训练免疫，系统疫苗学，免疫细胞。

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