Title:Effect of Lactobacillus rhamnosus and Diclofenac with Curcumin for Neuronal
Restoration and Repair Against Scopolamine Induced Dementia in
Zebrafish (Danio rerio)
Volume: 19
Issue: 2
Author(s): Sonal Pande*Chirag Patel
Affiliation:
- Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad, India
Keywords:
Zebrafish, Alzheimer’s disease, curcumin, diclofenac, probiotics, neurodegenerative
Abstract:
Background: Clinical studies have already revealed the ubiquitous neuroprotective role of
curcumin in neuronal deterioration, but it cannot be used alone due to its truncated bioavailability. Currently,
many such approaches are functional, which overcome this issue either by increasing the solubility
or absorption. These approaches carry a costlier treatment. One more tactic is present but less focused
i.e., by limiting the intestine and liver enzymatic metabolism; by this approach, curcumin will be
more available for its beneficial outcome.
Objective: The goal of this study was to evaluate the impact of Lactobacillus rhamnosus and diclofenac
on the neuroprotective effects of curcumin against scopolamine-induced dementia.
Methods: Physical parameters involved a novel tank test, T maze test, whereas neurochemical parameters
include brain oxidative stress and acetylcholinesterase (Ache) inhibition activity in a zebrafish dementia
model.
Results: Our results demonstrated that curcumin with Lactobacillus rhamnosus and diclofenac significantly
(p<0.05) reduced anxiety, memory deficits, and brain oxidative stress compared to the alone curcumin-
treated group.
Conclusion: This result approves that curcumin with L.rhamnosus and diclofenac have superior activity
compared to curcumin alone. However, further clinical studies are needed to validate these findings.