Title:Polyvinyl Alcohol Nanofibers Blends as Drug Delivery System in Tissue
Regeneration
Volume: 29
Issue: 15
Author(s): Camila Beatriz Barros Araújo, Ingrid Larissa da Silva Soares, Diego Paulo da Silva Lima, Rafaella Moreno Barros, Bolívar Ponciano Goulart de Lima Damasceno and João Augusto Oshiro-Junior*
Affiliation:
- Pharmaceutical Sciences Postgraduate Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda,
S/N, Campina Grande, 58429-600, Paraíba, Brazil
- Research Center in Pharmaceutical Sciences, UNIFACISA University Center,
Manoel Cardoso Palhano, Campina Grande, 58408-326, Paraíba, Brazil
Keywords:
Nanotechnology, nanomedicine, polymers, scaffolds, drug delivery, electrospinning.
Abstract: Nanofibers have shown promising clinical results in the process of tissue regeneration since they provide
a similar structure to the extracellular matrix of different tissues, high surface-to-volume ratio and porosity,
flexibility, and gas permeation, offering topographical features that stimulate cell adhesion and proliferation.
Electrospinning is one of the most used techniques for manufacturing nanomaterials due to its simplicity and
low cost. In this review, we highlight the use of nanofibers produced with polyvinyl alcohol and polymeric associations
(PVA/blends) as a matrix for release capable of modifying the pharmacokinetic profile of different active
ingredients in the regeneration of connective, epithelial, muscular, and nervous tissues. Articles were selected
by three independent reviewers by analyzing the databases, such as Web of Science, PubMed, Science Direct,
and Google Scholar (last 10 years). Descriptors used were “nanofibers”, “poly (vinyl alcohol)”, “muscle
tissue”, “connective tissue”, “epithelial tissue”, and “neural tissue engineering”. The guiding question was:
How do different compositions of polyvinyl alcohol polymeric nanofibers modify the pharmacokinetics of active
ingredients in different tissue regeneration processes? The results demonstrated the versatility of the production
of PVA nanofibers by solution blow technique with different actives (lipo/hydrophilic) and with pore
sizes varying between 60 and 450 nm depending on the polymers used in the mixture, which influences the
drug release that can be controlled for hours or days. The tissue regeneration showed better cellular organization
and greater cell proliferation compared to the treatment with the control group, regardless of the tissue analyzed.
We highlight that, among all blends, the combinations PVA/PCL and PVA/CS showed good compatibility
and slow degradation, indicating their use in prolonged times of biodegradation, thus benefiting tissue regeneration
in bone and cartilage connective tissues, acting as a physical barrier that results in guided regeneration,
and preventing the invasion of cells from other tissues with increased proliferation rate.
