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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Mini-Review Article

Natural Compounds Used for Treating Hair Loss

Author(s): Amin Gasmi, Pavan Kumar Mujawdiya, Natalia Beley, Mariia Shanaida, Roman Lysiuk, Larysa Lenchyk, Sadaf Noor, Akram Muhammad, Oksana Strus, Salva Piscopo, Andriy Komisarenko, Maryana Fedorovska and Geir Bjørklund*

Volume 29, Issue 16, 2023

Published on: 31 May, 2023

Page: [1231 - 1244] Pages: 14

DOI: 10.2174/1381612829666230505100147

Price: $65

Open Access Journals Promotions 2
Abstract

Hair loss or alopecia is a common dermatological condition affecting up to 2% of the world population. It is often caused by hereditary factors, such as male or female pattern baldness, but it can also result from various environmental factors, an unbalanced diet, or chronic illness. While hair loss is not life-threatening, it can cause significant anxiety, depression, and other psychological problems, ultimately impacting an individual's quality of life. Various treatments for hair loss, including both synthetic drugs, such as minoxidil and finasteride, or medicinal herbs, have been approved by the Food and Drug Administration. Despite synthetic drugs' effectiveness, they may come with potential side effects. Natural remedies have been proposed as a viable option for treating hair loss because many chronic disorders can cause alopecia. As such, this review focuses on identifying alternative, efficient treatment agents with limited side effects. Specifically, it looks into medicinal plants as potential healing agents for treating hair loss. To gather relevant information for the study, multiple databases were searched, including Scopus, PubMed, and Google Scholar. A comprehensive search was conducted using a range of search terms, such as “hair loss”, “alopecia”, “natural remedies for hair loss”, “herbal treatments for hair loss”, and others to extract relevant scientific articles. Many medicinal plants and natural compounds have shown potential in reducing hair loss, thanks to their anti-inflammatory and antioxidant properties and the ability to improve local metabolism when applied externally. According to existing literature, herbal extracts and formulations derived from plants, such as Urtica dioica, Humulus lupulus, Serenoa repens, Vitis vinifera, Pygeum africanum, Cucurbita pepo, etc., as well as certain individual herbal compounds, micronutrients, bee products, and keratin, may be effective in reducing hair loss directly or indirectly. Research suggests that medicinal plants and a variety of natural compounds hold promise in promoting hair growth and preventing alopecia.

Keywords: Alopecia, medicinal plants, nutraceuticals, cosmeceuticals, minoxidil, Cucurbita pepo, hair follicles, anxiety.

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[1]
Park S, Lee J. Modulation of hair growth promoting effect by natural products. Pharmaceutics 2021; 13(12): 2163.
[http://dx.doi.org/10.3390/pharmaceutics13122163] [PMID: 34959442]
[2]
Yamada T, Hara K, Umematsu H, Kadowaki T. Male pattern baldness and its association with coronary heart disease: A meta-analysis. BMJ Open 2013; 3(4): e002537.
[http://dx.doi.org/10.1136/bmjopen-2012-002537] [PMID: 23554099]
[3]
Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The role of vitamins and minerals in hair loss: a review. Dermatol Ther (Heidelb) 2019; 9(1): 51-70.
[http://dx.doi.org/10.1007/s13555-018-0278-6] [PMID: 30547302]
[4]
Hair Loss Medication Market 2019 Global Industry – Key Players, Size, Trends, Opportunities, Growth Analysis and Forecast to 2025. 2021. Available from:https://www.einnews.com/pr_news/503261723/hair-loss-medications-market-2019-global-industry-analysis-by-key-players-trends-segmentation-and-forecast-by-2025
[5]
Barton VR, Toussi A, Awasthi S, Kiuru M. Treatment of pediatric alopecia areata: A systematic review. J Am Acad Dermatol 2022; 86(6): 1318-34.
[http://dx.doi.org/10.1016/j.jaad.2021.04.077] [PMID: 33940103]
[6]
Zgonc Škulj A, Poljšak N, Kočevar Glavač N, Kreft S. Herbal preparations for the treatment of hair loss. Arch Dermatol Res 2020; 312(6): 395-406.
[http://dx.doi.org/10.1007/s00403-019-02003-x] [PMID: 31680216]
[7]
Ross EK, Tan E, Shapiro J. Update on primary cicatricial alopecias. J Am Acad Dermatol 2005; 53(1): 1-37.
[http://dx.doi.org/10.1016/j.jaad.2004.06.015] [PMID: 15965418]
[8]
Semalty M, Semalty A, Joshi GP, Rawat MSM. Hair growth and rejuvenation: An overview. J Dermatolog Treat 2011; 22(3): 123-32.
[http://dx.doi.org/10.3109/09546630903578574] [PMID: 20536276]
[9]
Patel S, Sharma V, Chauhan N, Thakur M, Dixit VK. N.; Thakur, M.; Dixit, V.K. Hair growth: focus on herbal therapeutic agent. Curr Drug Discov Technol 2015; 12(1): 21-42.
[http://dx.doi.org/10.2174/1570163812666150610115055] [PMID: 26058803]
[10]
Vary JC Jr. Selected disorders of skin appendages-acne, alopecia, hyperhidrosis. Med Clin North Am 2015; 99(6): 1195-211.
[http://dx.doi.org/10.1016/j.mcna.2015.07.003] [PMID: 26476248]
[11]
Mao Y, Xu Z, Song J, Xie Y, Mei X, Shi W. Efficacy of a mixed preparation containing piperine, capsaicin and curcumin in the treatment of alopecia areata. J Cosmet Dermatol 2022; 21(10): 4510-4.
[http://dx.doi.org/10.1111/jocd.14931] [PMID: 35318791]
[12]
Higgins CA, Christiano AM. Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia. Regen Med 2014; 9(1): 101-11.
[http://dx.doi.org/10.2217/rme.13.87] [PMID: 24351010]
[13]
Huang M, Zhou X. Appraisal of guidelines for androgenetic alopecia using the Appraisal of Guidelines for Research and Evaluation II instrument. J Eval Clin Pract 2015; 21(6): 1089-94.
[http://dx.doi.org/10.1111/jep.12474] [PMID: 26507460]
[14]
Ellis JA, Sinclair R, Harrap SB. Androgenetic alopecia: pathogenesis and potential for therapy. Expert Rev Mol Med 2002; 4(22): 1-11.
[http://dx.doi.org/10.1017/S1462399402005112] [PMID: 14585162]
[15]
Gupta AK, Talukder M, Bamimore MA. Natural products for male androgenetic alopecia. Dermatol Ther 2022; 35(4): e15323.
[http://dx.doi.org/10.1111/dth.15323] [PMID: 35044013]
[16]
Goren A, Shapiro J, Roberts J, et al. Clinical utility and validity of minoxidil response testing in androgenetic alopecia. Dermatol Ther 2015; 28(1): 13-6.
[http://dx.doi.org/10.1111/dth.12164] [PMID: 25112173]
[17]
Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: A randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014; 2014: 549721.
[http://dx.doi.org/10.1155/2014/549721]
[18]
Surya D, Legiawati L, Kamila N, Suseno LS, Sitohang IBS. Alopecia areata universalis showing excellent response to combination treatment modalities. J Pak Assoc Dermatol 2022; 32: 425-9.
[19]
Bjørklund G, Shanaida M, Lysiuk R, et al. Natural compounds and products from an anti-aging perspective. Molecules 2022; 27(20): 7084.
[http://dx.doi.org/10.3390/molecules27207084] [PMID: 36296673]
[20]
Ablon G. Nutraceuticals. Dermatol Clin 2021; 39(3): 417-27.
[http://dx.doi.org/10.1016/j.det.2021.03.006] [PMID: 34053595]
[21]
Bjørklund G, Shanaida M, Lysiuk R, et al. Selenium: an antioxidant with a critical role in anti-aging. Molecules 2022; 27(19): 6613.
[http://dx.doi.org/10.3390/molecules27196613] [PMID: 36235150]
[22]
Suchonwanit P, Thammarucha S, Leerunyakul K. Minoxidil and its use in hair disorders: a review. Drug Des Devel Ther 2019; 13: 2777-86.
[http://dx.doi.org/10.2147/DDDT.S214907] [PMID: 31496654]
[23]
Hanneken S, Ritzmann S, Nöthen M, Kruse R. Androgenetische Alopezie. Hautarzt 2003; 54: 703-12.
[http://dx.doi.org/10.1007/s00105-003-0561-y] [PMID: 12942184]
[24]
Lourith N, Kanlayavattanakul M. Hair loss and herbs for treatment. J Cosmet Dermatol 2013; 12(3): 210-22.
[http://dx.doi.org/10.1111/jocd.12051] [PMID: 23992163]
[25]
Hosking AM, Juhasz M, Atanaskova Mesinkovska N. Complementary and alternative treatments for alopecia: a comprehensive review. Skin Appendage Disord 2019; 5(2): 72-89.
[http://dx.doi.org/10.1159/000492035] [PMID: 30815439]
[26]
Shen YL, Li XQ, Pan RR, Yue W, Zhang LJ, Zhang H. Medicinal plants for the treatment of hair loss and the suggested mechanisms. Curr Pharm Des 2018; 24(26): 3090-100.
[http://dx.doi.org/10.2174/1381612824666180911114810] [PMID: 30205796]
[27]
Asnaashari S, Javadzadeh Y. Herbal medicines for treatment of androgenic alopecia. Altern Ther Health Med 2020; 26(4): 27-35.
[PMID: 31221945]
[28]
Trüeb R. Oxidative stress in ageing of hair. Int J Trichology 2009; 1(1): 6-14.
[http://dx.doi.org/10.4103/0974-7753.51923] [PMID: 20805969]
[29]
Trüeb R, Henry J, Davis M, Schwartz J. Scalp condition impacts hair growth and retention via oxidative stress. Int J Trichology 2018; 10(6): 262-70.
[http://dx.doi.org/10.4103/ijt.ijt_57_18] [PMID: 30783333]
[30]
Cornara L, Xiao J, Burlando B. Therapeutic potential of temperate forage legumes: a review. Crit Rev Food Sci Nutr 2016; 56(sup1) (Suppl. 1): S149-61.
[http://dx.doi.org/10.1080/10408398.2015.1038378] [PMID: 26507574]
[31]
Zálešák F, Bon DJYD, Pospíšil J. Lignans and neolignans: Plant secondary metabolites as a reservoir of biologically active substances. Pharmacol Res 2019; 146: 104284.
[http://dx.doi.org/10.1016/j.phrs.2019.104284] [PMID: 31136813]
[32]
Venturelli S, Burkard M, Biendl M, Lauer UM, Frank J, Busch C. Prenylated chalcones and flavonoids for the prevention and treatment of cancer. Nutrition 2016; 32(11-12): 1171-8.
[http://dx.doi.org/10.1016/j.nut.2016.03.020] [PMID: 27238957]
[33]
Swamy MK, Sinniah UR, Ghasemzadeh A. Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics. Appl Microbiol Biotechnol 2018; 102(18): 7775-93.
[http://dx.doi.org/10.1007/s00253-018-9223-y] [PMID: 30022261]
[34]
Bassino E, Gasparri F, Munaron L. Serenoa repens and N-acetyl glucosamine/milk proteins complex differentially affect the paracrine communication between endothelial and follicle dermal papilla cells. J Cell Physiol 2019; 234(5): 7320-9.
[http://dx.doi.org/10.1002/jcp.27491] [PMID: 30417926]
[35]
McNicholas T, Kirby R. Benign prostatic hyperplasia and male lower urinary tract symptoms (LUTS). BMJ Clin Evid 2011; 2011: 1801.
[36]
Kanti V, Messenger A, Dobos G, et al. Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men - short version. J Eur Acad Dermatol Venereol 2018; 32(1): 11-22.
[http://dx.doi.org/10.1111/jdv.14624] [PMID: 29178529]
[37]
Santos HO, Howell S, Teixeira FJ. Beyond tribulus (Tribulus terrestris L.): The effects of phytotherapics on testosterone, sperm and prostate parameters. J Ethnopharmacol 2019; 235: 392-405.
[http://dx.doi.org/10.1016/j.jep.2019.02.033] [PMID: 30790614]
[38]
Pekmezci E, Dündar C, Türkoğlu M. A proprietary herbal extract against hair loss in androgenetic alopecia and telogen effluvium: a placebo-controlled, single-blind, clinical-instrumental study. Acta Dermatovenerol Alp Panonica Adriat 2018; 27(2): 51-7.
[http://dx.doi.org/10.15570/actaapa.2018.13] [PMID: 29945259]
[39]
Seiman DD, Batalu A, Seiman DC, et al. Pharmacological effects of natural compounds extracted from Urtica dioica evaluated by in silico and experimental methods. Revista de Chimie 2018; 69(9): 2377-81.
[http://dx.doi.org/10.37358/RC.18.9.6537]
[40]
Timoshenko AV, Kayser K, Kaltner H, André S, Gabius HJ. Binding capacities of two immunomodulatory lectins, carrier-immobilized glycoligands and steroid hormones in lung cancer and the concentration of nitrite/nitrate in pleural effusions. Lung Cancer 1996; 14(1): 75-84.
[http://dx.doi.org/10.1016/0169-5002(95)00513-7] [PMID: 8696722]
[41]
Rastegar H, Ahmadi Ashtiani H, Aghaei M, Ehsani A, Barikbin B. Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways. J Cosmet Dermatol 2013; 12(2): 116-22.
[http://dx.doi.org/10.1111/jocd.12033] [PMID: 23725305]
[42]
Gülçin İ, Küfrevioǧlu Öİ, Oktay M, Büyükokuroǧlu ME. Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). J Ethnopharmacol 2004; 90(2-3): 205-15.
[http://dx.doi.org/10.1016/j.jep.2003.09.028] [PMID: 15013182]
[43]
Ivanivna FM, Petrivna PN, Mykolaivna FS, Vasylivna AO. Study of vasodilating and regenerative effect of the gel with nettle juice intended for Telogen effluvium treatment. J Appl Pharm Sci 2018; 8(1): 93-7.
[44]
Štulíková K, Karabín M, Nešpor J, Dostálek P. Therapeutic perspectives of 8-prenylnaringenin, a potent phytoestrogen from hops. Molecules 2018; 23(3): 660.
[http://dx.doi.org/10.3390/molecules23030660] [PMID: 29543713]
[45]
Rietjens IMCM, Louisse J, Beekmann K. The potential health effects of dietary phytoestrogens. Br J Pharmacol 2017; 174(11): 1263-80.
[http://dx.doi.org/10.1111/bph.13622] [PMID: 27723080]
[46]
Yang X, Jiang Y, Yang J, et al. Prenylated flavonoids, promising nutraceuticals with impressive biological activities. Trends Food Sci Technol 2015; 44(1): 93-104.
[http://dx.doi.org/10.1016/j.tifs.2015.03.007]
[47]
Karabin M, Hudcova T, Jelinek L, Dostalek P. Biotransformations and biological activities of hop flavonoids. Biotechnol Adv 2015; 33(6): 1063-90.
[http://dx.doi.org/10.1016/j.biotechadv.2015.02.009] [PMID: 25708386]
[48]
Terao J, Mukai R. Prenylation modulates the bioavailability and bioaccumulation of dietary flavonoids. Arch Biochem Biophys 2014; 559: 12-6.
[http://dx.doi.org/10.1016/j.abb.2014.04.002] [PMID: 24736381]
[49]
Erkkola R, Vervarcke S, Vansteelandt S, Rompotti P, De Keukeleire D, Heyerick A. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine 2010; 17(6): 389-96.
[http://dx.doi.org/10.1016/j.phymed.2010.01.007] [PMID: 20167461]
[50]
Chadwick LR, Pauli GF, Farnsworth NR. The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties. Phytomedicine 2006; 13(1-2): 119-31.
[http://dx.doi.org/10.1016/j.phymed.2004.07.006] [PMID: 16360942]
[51]
Dhariwala MY, Ravikumar P. An overview of herbal alternatives in androgenetic alopecia. J Cosmet Dermatol 2019; 18(4): jocd.12930.
[http://dx.doi.org/10.1111/jocd.12930] [PMID: 30980598]
[52]
Chittur S, Parr B, Marcovici G. Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic acid and saw palmetto extract. Evid Based Complement Alternat Med 2011; 2011: 985345.
[http://dx.doi.org/10.1093/ecam/nep102]
[53]
Zhu HL, Gao YH, Yang JQ, Li JB, Gao J. Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-β and mitochondrial signaling pathway. Eur Rev Med Pharmacol Sci 2018; 22(12): 4000-8.
[PMID: 29949176]
[54]
Rossi A, Campo D, Fortuna MC, et al. A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia. J Dermatolog Treat 2018; 29(2): 149-51.
[http://dx.doi.org/10.1080/09546634.2017.1341610] [PMID: 28604133]
[55]
Morabito P, Miroddi M, Giovinazzo S, Spina E, Calapai G. Serenoa repens as an endocrine disruptor in a 10-year-old young girl: a new case report. Pharmacology 2015; 96(1-2): 41-3.
[http://dx.doi.org/10.1159/000431327] [PMID: 26043832]
[56]
Wessagowit V, Tangjaturonrusamee C, Kootiratrakarn T, et al. Treatment of male androgenetic alopecia with topical products containing S erenoa repens extract. Australas J Dermatol 2016; 57(3): e76-82.
[http://dx.doi.org/10.1111/ajd.12352] [PMID: 26010505]
[57]
Rossi A, Mari E, Scarnò M, et al. Comparitive effectiveness of finasteride vs. Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol 2012; 25(4): 1167-73.
[http://dx.doi.org/10.1177/039463201202500435] [PMID: 23298508]
[58]
Sharif A, Akhtar N, Khan MS, et al. Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract. Int J Cosmet Sci 2015; 37(2): 253-8.
[http://dx.doi.org/10.1111/ics.12184] [PMID: 25402429]
[59]
Ky I, Teissedre PL. Characterisation of Mediterranean grape pomace seed and skin extracts: polyphenolic content and antioxidant activity. Molecules 2015; 20(2): 2190-207.
[http://dx.doi.org/10.3390/molecules20022190] [PMID: 25642834]
[60]
Bjørklund G, Dadar M, Martins N, et al. Brief challenges on medicinal plants: an eye-opening look at ageing-related disorders. Basic Clin Pharmacol Toxicol 2018; 122(6): 539-58.
[http://dx.doi.org/10.1111/bcpt.12972] [PMID: 29369521]
[61]
Filip GA, Postescu ID, Bolfa P, Catoi C, Muresan A, Clichici S. Inhibition of UVB-induced skin phototoxicity by a grape seed extract as modulator of nitrosative stress, ERK/NF-kB signaling pathway and apoptosis, in SKH-1 mice. Food Chem Toxicol 2013; 57: 296-306.
[http://dx.doi.org/10.1016/j.fct.2013.03.031] [PMID: 23567245]
[62]
Felice F, Zambito Y, Di Colo G, et al. Red grape skin and seeds polyphenols: Evidence of their protective effects on endothelial progenitor cells and improvement of their intestinal absorption. Eur J Pharm Biopharm 2012; 80(1): 176-84.
[http://dx.doi.org/10.1016/j.ejpb.2011.09.002] [PMID: 21971368]
[63]
Nassiri-Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive constituents: an update. Phytother Res 2016; 30(9): 1392-403.
[http://dx.doi.org/10.1002/ptr.5644] [PMID: 27196869]
[64]
Takahashi T, Kamiya T, Yokoo Y. Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. Acta Derm Venereol 1998; 78(6): 428-32.
[http://dx.doi.org/10.1080/000155598442719] [PMID: 9833041]
[65]
Esmaeilzadeh Z, Shabanizadeh A, Taghipour Z, Vazirinejad R, Salahshoor MR, Taghavi MM. Effect of topical grape sap on apoptosis in hair follicle among male rats. Gene Cell Tissue 2021; 9(3)
[http://dx.doi.org/10.5812/gct.115426]
[66]
Magro CM, Rossi A, Poe J, Manhas-Bhutani S, Sadick N. The role of inflammation and immunity in the pathogenesis of androgenetic alopecia. J Drugs Dermatol 2011; 10(12): 1404-11.
[PMID: 22134564]
[67]
Jena AK, Vasisht K, Sharma N, Kaur R, Dhingra MS, Karan M. Amelioration of testosterone induced benign prostatic hyperplasia by Prunus species. J Ethnopharmacol 2016; 190: 33-45.
[http://dx.doi.org/10.1016/j.jep.2016.05.052] [PMID: 27235020]
[68]
Keehn A, Taylor J, Lowe FC. Phytotherapy for benign prostatic hyperplasia. Curr Urol Rep 2016; 17(7): 53.
[http://dx.doi.org/10.1007/s11934-016-0609-z] [PMID: 27180172]
[69]
Keehn A, Lowe FC. Complementary and alternative medications for benign prostatic hyperplasia. Can J Urol 2015; 22 (Suppl. 1): 18-23.
[PMID: 26497340]
[70]
Allkanjari O, Vitalone A. What do we know about phytotherapy of benign prostatic hyperplasia? Life Sci 2015; 126: 42-56.
[http://dx.doi.org/10.1016/j.lfs.2015.01.023] [PMID: 25703069]
[71]
Shenouda NS, Sakla MS, Newton LG, et al. Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo. Endocr J 2007; 31(1): 72-81.
[http://dx.doi.org/10.1007/s12020-007-0014-y] [PMID: 17709901]
[72]
Rathi V, Rathi J, Tamizharasi S, Pathak A. Plants used for hair growth promotion: A review. Pharmacogn Rev 2008; 2: 185.
[73]
Zagayko A, Senuyk I, Lenchyk L, Galimullin R. Study of antioxidant activity of the extract from plum ordinary leaves. Ukrainian Biopharm J 2014; 1: 25-8.
[74]
Karimi Z, Firouzi M, Dadmehr M, Javad-Mousavi SA, Bagheriani N, Sadeghpour O. Almond as a nutraceutical and therapeutic agent in Persian medicine and modern phytotherapy: A narrative review. Phytother Res 2021; 35(6): 2997-3012.
[http://dx.doi.org/10.1002/ptr.7006] [PMID: 33368772]
[75]
Mykhailenko O, Petrikaitė V, Korinek M, et al. Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation. BMC Complement Med Ther 2021; 21: 1-15.
[76]
Hausenblas HA, Saha D, Dubyak PJ, Anton SD. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med 2013; 11(6): 377-83.
[http://dx.doi.org/10.3736/jintegrmed2013056] [PMID: 24299602]
[77]
Kell G, Rao A, Beccaria G, Clayton P, Inarejos-García AM, Prodanov M. Affron ® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med 2017; 33: 58-64.
[http://dx.doi.org/10.1016/j.ctim.2017.06.001] [PMID: 28735826]
[78]
Akhondzadeh Basti A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S. Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(2): 439-42.
[http://dx.doi.org/10.1016/j.pnpbp.2006.11.010] [PMID: 17174460]
[79]
Mall TP, Tripathi S. Saffron-a treasure of the ancient medicine chest-an overview. World J Pharm Res 2017; 6: 1604-23.
[http://dx.doi.org/10.20959/wjpr20174-8285]
[80]
Balestrazzi A, Carbonera D, Avato P, Tava A. White poplar (Populus alba L.) suspension cultures as a model system to study apoptosis induced by alfalfa saponins. Anticancer Agents Med Chem 2014; 14(10): 1324-31.
[http://dx.doi.org/10.2174/1872211308666140630123406] [PMID: 24998401]
[81]
Gaweł E. Chemical composition of lucerne leaf extract (EFL) and its applications as a phytobiotic in human nutrition. Acta Sci Pol Technol Aliment 2012; 11(3): 303-10.
[PMID: 22744951]
[82]
Bora KS, Sharma A. The genus Artemisia: a comprehensive review. Pharm Biol 2011; 49(1): 101-9.
[http://dx.doi.org/10.3109/13880209.2010.497815] [PMID: 20681755]
[83]
De Leo V, Lanzetta D, Cazzavacca R, Morgante G. Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent. Minerva Ginecol 1998; 50(5): 207-11.
[PMID: 9677811]
[84]
Chang H, Yao S, Tritchler D, et al. Genetic variation in steroid and xenobiotic metabolizing pathways and enterolactone excretion before and after flaxseed intervention in African American and European American women. Cancer Epidemiol Biomarkers Prev 2019; 28(2): 265-74.
[http://dx.doi.org/10.1158/1055-9965.EPI-18-0826] [PMID: 30709839]
[85]
Kezimana P, Dmitriev AA, Kudryavtseva AV, Romanova EV, Melnikova NV. Secoisolariciresinol diglucoside of flaxseed and its metabolites: Biosynthesis and potential for nutraceuticals. Front Genet 2018; 9: 641.
[http://dx.doi.org/10.3389/fgene.2018.00641] [PMID: 30619466]
[86]
Di Y, Jones J, Mansell K, et al. Influence of flaxseed lignan supplementation to older adults on biochemical and functional outcome measures of inflammation. J Am Coll Nutr 2017; 36(8): 646-53.
[http://dx.doi.org/10.1080/07315724.2017.1342213] [PMID: 28922068]
[87]
Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M. Effects of flaxseed supplements on blood pressure: A systematic review and meta-analysis of controlled clinical trial. Clin Nutr 2016; 35(3): 615-25.
[http://dx.doi.org/10.1016/j.clnu.2015.05.012] [PMID: 26071633]
[88]
Azrad M, Vollmer RT, Madden J, et al. Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. J Med Food 2013; 16(4): 357-60.
[http://dx.doi.org/10.1089/jmf.2012.0159] [PMID: 23566060]
[89]
Goel A. How to make your hair thicker and increase hair volume. Available from: https://www.myupchar.com/en/beauty/hair-growth/balo-ko-ghana-karne-ke-gharelu-upay-in-hindi#flaxseeds-for-thick-hair
[90]
Manjula D, Jenita J, Premakumari K, Shanaz B. Formulation and evaluation of flaxseed hair gel: a natural hair tamer. Int J Res Pharm Chem 2018; 8: 487-91.
[91]
Vanduchova A, Anzenbacher P, Anzenbacherova E. Isothiocyanate from broccoli, sulforaphane, and its properties. J Med Food 2019; 22(2): 121-6.
[http://dx.doi.org/10.1089/jmf.2018.0024] [PMID: 30372361]
[92]
Jiang X, Liu Y, Ma L, et al. Chemopreventive activity of sulforaphane. Drug Des Devel Ther 2018; 12: 2905-13.
[http://dx.doi.org/10.2147/DDDT.S100534] [PMID: 30254420]
[93]
Haslam IS, Jadkauskaite L, Szabó IL, et al. Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition. J Invest Dermatol 2017; 137(2): 295-304.
[http://dx.doi.org/10.1016/j.jid.2016.08.035] [PMID: 27702566]
[94]
Nehlich O, Richards MP. Establishing collagen quality criteria for sulphur isotope analysis of archaeological bone collagen. Archaeol Anthropol Sci 2009; 1(1): 59-75.
[http://dx.doi.org/10.1007/s12520-009-0003-6]
[95]
Fahey JW, Holtzclaw WD, Wehage SL, Wade KL, Stephenson KK, Talalay P. Sulforaphane bioavailability from glucoraphanin-rich broccoli: Control by active endogenous myrosinase. PLoS One 2015; 10(11): e0140963.
[http://dx.doi.org/10.1371/journal.pone.0140963] [PMID: 26524341]
[96]
Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct 2014; 5(1): 35-41.
[http://dx.doi.org/10.1039/C3FO60277J] [PMID: 24287881]
[97]
Egner PA, Chen JG, Zarth AT, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila) 2014; 7(8): 813-23.
[http://dx.doi.org/10.1158/1940-6207.CAPR-14-0103] [PMID: 24913818]
[98]
Abarikwu SO, Oleribe AL, Mgbudom-Okah CJ, Onuah CL, Chikwendu CS, Onyeike EN. The protective effect of fluted pumpkin seeds against atrazine-induced testicular injury. Drug Chem Toxicol 2022; 45(2): 799-809.
[http://dx.doi.org/10.1080/01480545.2020.1776723] [PMID: 32538183]
[99]
da Cruz GK, Martins MIM, Antunes FTT, et al. Evaluation of the efficacy and toxicity of oral and topical pumpkin oil on the hair growth of mice. Acta Histochem 2022; 124(4): 151894.
[http://dx.doi.org/10.1016/j.acthis.2022.151894] [PMID: 35447441]
[100]
Hajhashemi V, Rajabi P, Mardani M. Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model. Avicenna J Phytomed 2019; 9(6): 499-504.
[PMID: 31763209]
[101]
Ibrahim IM, Hasan MS, Elsabaa KI, Elsaie ML. Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial. J Cosmet Dermatol 2021; 20(9): 2867-73.
[http://dx.doi.org/10.1111/jocd.13976] [PMID: 33544448]
[102]
Cabeza M, Bratoef E, Heuze I, Ramírez E, Sánchez M, Flores E. Effect of beta-sitosterol as inhibitor of 5alpha-reductase in hamster prostate. Proceedings of the Proceedings-Western Pharmacology Society. 153-5.
[103]
Raynaud JP, Cousse H, Martin PM. Inhibition of type 1 and type 2 5α-reductase activity by free fatty acids, active ingredients of Permixon®. J Steroid Biochem Mol Biol 2002; 82(2-3): 233-9.
[http://dx.doi.org/10.1016/S0960-0760(02)00187-5] [PMID: 12477490]
[104]
Ezekwe N, King M, Hollinger JC. The use of natural ingredients in the treatment of alopecias with an emphasis on central centrifugal cicatricial alopecia: a systematic review. J Clin Aesthet Dermatol 2020; 13(8): 23-7.
[PMID: 33178378]
[105]
Alyoussef A. Survey of use of herbal and home remedies for hair and scalp among women in North West Saudi Arabia. Dermatol Rep 2020; 12(2): 8651.
[http://dx.doi.org/10.4081/dr.2020.8651] [PMID: 33408832]
[106]
Boghrati Z, Sabouri-Rad S, Emami SA, Saber MT, Sahebkar A, Tayarani-Najaran Z. The use of medicinal plants for the treatment of Alopecia in the canon of avicenna: An evidence-based review. Adv Exp Med Biol 2021; 1308: 291-308.
[107]
Mahdi B, Abu-Huwaij R, Al-khateeb I. Development of topical patches releasing allicin using garlic extract. J Cosmet Dermatol 2022; 21(1): 396-402.
[http://dx.doi.org/10.1111/jocd.14553] [PMID: 34713965]
[108]
Rizg WY, Hosny KM, Elgebaly SS, et al. Preparation and Optimization of garlic oil/apple cider vinegar nanoemulsion loaded with minoxidil to treat alopecia. Pharmaceutics 2021; 13(12): 2150.
[http://dx.doi.org/10.3390/pharmaceutics13122150] [PMID: 34959435]
[109]
Sharquie KE, Al-Obaidi HK. Onion juice (Allium cepa L.), a new topical treatment for alopecia areata. J Dermatol 2002; 29(6): 343-6.
[http://dx.doi.org/10.1111/j.1346-8138.2002.tb00277.x] [PMID: 12126069]
[110]
Hay IC, Jamieson M, Ormerod AD. Randomized trial of aromatherapy. Successful treatment for alopecia areata. Arch Dermatol 1998; 134(11): 1349-52.
[http://dx.doi.org/10.1001/archderm.134.11.1349] [PMID: 9828867]
[111]
Panahi Y, Taghizadeh M, Marzony ET, Sahebkar A. Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. Skinmed 2015; 13(1): 15-21.
[PMID: 25842469]
[112]
Hosny KM, Rizg WY, Alfayez E, et al. Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia. Drug Deliv 2022; 29(1): 284-93.
[http://dx.doi.org/10.1080/10717544.2022.2026534] [PMID: 35019794]
[113]
Sadgrove NJ, Simmonds MSJ. Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual-acting” (2 for 1) plant-based peptides, hormones, and cannabinoids. FASEB Bioadv 2021; 3(8): 601-10.
[http://dx.doi.org/10.1096/fba.2021-00022] [PMID: 34377956]
[114]
Yang FC, Zhang Y, Rheinstädter MC. The structure of people’s hair. Peer J 2014; 2: e619.
[http://dx.doi.org/10.7717/peerj.619] [PMID: 25332846]
[115]
Beer C, Wood S, Veghte RH. A clinical trial to investigate the effect of cynatine HNS on hair and nail parameters. Sci World J 2014; 2014: 641723.
[http://dx.doi.org/10.1155/2014/641723]
[116]
Kelly RJ, Ellis GD, Macdonald RJ, et al. Keratin and soluble derivatives thereof for treating oxidative stress and inflammation and promoting skin health. PCT/US2006/008923, 2006.
[117]
El-Wahed AAA, Khalifa SAM, Elashal MH, et al. Cosmetic applications of bee venom. Toxins (Basel) 2021; 13(11): 810.
[http://dx.doi.org/10.3390/toxins13110810] [PMID: 34822594]
[118]
Park S, Erdogan S, Hwang D, Hwang S, Han EH, Lim YH. Bee venom promotes hair growth in association with inhibiting 5α-reductase expression. Biol Pharm Bull 2016; 39(6): 1060-8.
[http://dx.doi.org/10.1248/bpb.b16-00158]
[119]
Rinaldi F, Trink A, Pinto D. Efficacy of postbiotics in a PRP-like cosmetic product for the treatment of alopecia area Celsi: a randomized double-blinded parallel-group study. Dermatol Ther (Heidelb) 2020; 10(3): 483-93.
[http://dx.doi.org/10.1007/s13555-020-00369-9] [PMID: 32279227]
[120]
Nguyen BCQ, Taira N, Maruta H, Tawata S. Artepillin C and other herbal PAK1-blockers: effects on hair cell proliferation and related PAK1-dependent biological function in cell culture. Phytother Res 2016; 30(1): 120-7.
[http://dx.doi.org/10.1002/ptr.5510] [PMID: 26537230]
[121]
Bjørklund G, Dadar M, Chirumbolo S, Lysiuk R. Flavonoids as detoxifying and pro-survival agents: What’s new? Food Chem Toxicol 2017; 110: 240-50.
[http://dx.doi.org/10.1016/j.fct.2017.10.039] [PMID: 29079495]
[122]
Kim S, Kim H. Inhibitory effect of astaxanthin on oxidative stress-induced mitochondrial dysfunction-a mini-review. Nutrients 2018; 10(9): 1137.
[http://dx.doi.org/10.3390/nu10091137] [PMID: 30134611]
[123]
Bjørklund G, Gasmi A, Lenchyk L, et al. The role of astaxanthin as a nutraceutical in health and age-related conditions. Molecules 2022; 27(21): 7167.
[http://dx.doi.org/10.3390/molecules27217167] [PMID: 36363994]
[124]
Fakhri S, Abbaszadeh F, Dargahi L, Jorjani M. Astaxanthin: A mechanistic review on its biological activities and health benefits. Pharmacol Res 2018; 136: 1-20.
[http://dx.doi.org/10.1016/j.phrs.2018.08.012] [PMID: 30121358]
[125]
Gasmi A, Mujawdiya PK, Shanaida M, et al. Calanus oil in the treatment of obesity-related low-grade inflammation, insulin resistance, and atherosclerosis. Appl Microbiol Biotechnol 2020; 104(3): 967-79.
[http://dx.doi.org/10.1007/s00253-019-10293-4] [PMID: 31853565]
[126]
Šimat V, Rathod NB, Čagalj M, Hamed I, Generalić Mekinić I. Astaxanthin from crustaceans and their byproducts: a bioactive metabolite candidate for therapeutic application. Mar Drugs 2022; 20(3): 206.
[http://dx.doi.org/10.3390/md20030206] [PMID: 35323505]
[127]
Ito N, Seki S, Ueda F. The protective role of astaxanthin for UV-induced skin deterioration in healthy people—a randomized, double-blind, placebo-controlled trial. Nutrients 2018; 10(7): 817.
[http://dx.doi.org/10.3390/nu10070817] [PMID: 29941810]
[128]
Davinelli S, Nielsen M, Scapagnini G. Astaxanthin in skin health, repair, and disease: A comprehensive review. Nutrients 2018; 10(4): 522.
[http://dx.doi.org/10.3390/nu10040522] [PMID: 29690549]
[129]
Tominaga K, Hongo N, Fujishita M, Takahashi Y, Adachi Y. Protective effects of astaxanthin on skin deterioration. J Clin Biochem Nutr 2017; 61(1): 33-9.
[http://dx.doi.org/10.3164/jcbn.17-35] [PMID: 28751807]
[130]
Komatsu T, Sasaki S, Manabe Y, Hirata T, Sugawara T. Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice. PLoS One 2017; 12(2): e0171178.
[http://dx.doi.org/10.1371/journal.pone.0171178] [PMID: 28170435]
[131]
Chalyk NE, Klochkov VA, Bandaletova TY, Kyle NH, Petyaev IM. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers. Nutr Res 2017; 48: 40-8.
[http://dx.doi.org/10.1016/j.nutres.2017.10.006] [PMID: 29246280]
[132]
Zhang L, Wang H. Multiple mechanisms of anti-cancer effects exerted by astaxanthin. Mar Drugs 2015; 13(7): 4310-30.
[http://dx.doi.org/10.3390/md13074310] [PMID: 26184238]
[133]
Anunciato TP, da Rocha Filho PA. Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals. J Cosmet Dermatol 2012; 11(1): 51-4.
[http://dx.doi.org/10.1111/j.1473-2165.2011.00600.x] [PMID: 22360335]
[134]
Quispe C, Cruz-Martins N, Manca ML, et al. Nano-derived therapeutic formulations with curcumin in inflammation-related diseases. Oxid Med Cell Longev 2021; 2021: 3149223.
[135]
Gopinath H, Karthikeyan K. Turmeric: A condiment, cosmetic and cure. Indian J Dermatol Venereol Leprol 2018; 84(1): 16-21.
[http://dx.doi.org/10.4103/ijdvl.IJDVL_1143_16] [PMID: 29243674]
[136]
Harada N, Okajima K, Arai M, Kurihara H, Nakagata N. Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia. Growth Horm IGF Res 2007; 17(5): 408-15.
[http://dx.doi.org/10.1016/j.ghir.2007.04.009] [PMID: 17569567]
[137]
Bae S, Lim KM, Cha HJ, et al. Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells. Biol Res 2014; 47(1): 50.
[http://dx.doi.org/10.1186/0717-6287-47-50] [PMID: 25299961]
[138]
Kurnia D, Kelutur F, Mustarichie R. Potential anti-alopecia constituents from Theobroma cacao: An in silico study. J Adv Pharm Technol Res 2021; 12(2): 169-74.
[http://dx.doi.org/10.4103/japtr.JAPTR_329_20] [PMID: 34159149]
[139]
Bassino E, Gasparri F, Munaron L. Protective role of nutritional plants containing flavonoids in hair follicle disruption: A review. Int J Mol Sci 2020; 21(2): 523.
[http://dx.doi.org/10.3390/ijms21020523] [PMID: 31947635]
[140]
Mubki T. Use of vitamins and minerals in the treatment of hair loss: a cross-sectional survey among dermatologists in Saudi Arabia. J Cutan Med Surg 2014; 18(6): 405-12.
[http://dx.doi.org/10.2310/7750.2014.14008] [PMID: 25348762]
[141]
Bakry O, El Farargy S, El Shafiee M, Soliman A. Serum Vitamin D in patients with alopecia areata. Indian Dermatol Online J 2016; 7(5): 371-7.
[http://dx.doi.org/10.4103/2229-5178.190504] [PMID: 27730032]
[142]
Thompson JM, Mirza MA, Park MK, Qureshi AA, Cho E. The role of micronutrients in alopecia areata: a review. Am J Clin Dermatol 2017; 18(5): 663-79.
[http://dx.doi.org/10.1007/s40257-017-0285-x] [PMID: 28508256]
[143]
Toldy A, Stadler K, Sasvári M, et al. The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain. Brain Res Bull 2005; 65(6): 487-93.
[http://dx.doi.org/10.1016/j.brainresbull.2005.02.028] [PMID: 15862920]
[144]
Sinclair RD, Mallari RS, Tate B. Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia. Australas J Dermatol 2002; 43(4): 311-2.
[http://dx.doi.org/10.1046/j.1440-0960.2002.00620.x] [PMID: 12423443]
[145]
Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-α-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002; 8(2): 143-52.
[http://dx.doi.org/10.1089/107555302317371433] [PMID: 12006122]
[146]
Fedorovska M, Yarema I. Technology development of herbal remedies for androgenic alopecia external application. Pharma Innov 2015; 4: 26.
[147]
Olaku OO, Ojukwu MO, Zia FZ, White JD. The role of grape seed extract in the treatment of chemo/radiotherapy induced toxicity: a systematic review of preclinical studies. Nutr Cancer 2015; 67(5): 730-40.
[http://dx.doi.org/10.1080/01635581.2015.1029639] [PMID: 25880972]
[148]
Ramos PM, Miot HA. Female pattern hair loss: a clinical and pathophysiological review. An Bras Dermatol 2015; 90(4): 529-43.
[http://dx.doi.org/10.1590/abd1806-4841.20153370] [PMID: 26375223]
[149]
Thompson RQ, Katz D, Sheehan B. Chemical comparison of Prunus africana bark and pygeum products marketed for prostate health. J Pharm Biomed Anal 2019; 163: 162-9.
[http://dx.doi.org/10.1016/j.jpba.2018.10.004] [PMID: 30316061]
[150]
Kaushik R, Gupta D, Yadav R. Alopecia: herbal remedies. Int J Pharm Sci Res 2011; 2: 1631.

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