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The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Review Article

The Role of Different Medicinal Herbs in Treatment of Polycystic Ovary Syndrome: A Review

Author(s): Aastha Sharma, Keshav Bansal and Meenakshi Bajpai*

Volume 14, Issue 1, 2024

Published on: 17 May, 2023

Article ID: e020523216411 Pages: 9

DOI: 10.2174/2210315513666230502104141

Price: $65

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Abstract

Polycystic ovary syndrome (PCOS/PCOD) indicates a common, multifactorial endocrine condition marked by polycystic ovaries, chronic anovulation, and hyperandrogenism, resulting in asymmetric menstrual periods, hirsutism, acne, and infertility. Standard treatment for PCOS is often accompanied by adverse effects, and is ineffective in certain situations, refutation-based medical guidance accented an integrative progress. Furthermore, women suffering from PCOS may benefit from alternative treatments. Herbal treatment includes herbs that have a phytoestrogenic and non-estrogenic nature, including Mentha spicata, Panax ginseng, Glycyrrhiza glabra, Aloe barbadensis, Cinnamomum zeylanicum, Matricaria chamomilla, Trigonella foenum-graecum, Linum usitatissimum, and Zingiber officinale, which are effective and safe. This review focuses on the reproductive endocrine effects of phytomedicine as a choice treatment so as to PCOD and accompanying oligo/amenorrhoea, acne, hirsutism, and infertility.

Keywords: Polycystic ovary syndrome, hirsutism, herbs, acne, amenorrhoea, natural medicine, hormone abnormality.

Graphical Abstract
[1]
Goswami, P.K.; Khale, S.O. Natural remedies for Polycystic Ovarian Syndrome (PCOS): A review. Int. J. Pharm. Phytopharm. Res., 2012, 1(6), 396-402.
[2]
Arentz, S.; Abbott, J.A.; Smith, C.A.; Bensoussan, A. Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; A review of the laboratory evidence for effects with corroborative clinical findings. BMC Complement. Altern. Med., 2014, 14(1), 511-530.
[http://dx.doi.org/10.1186/1472-6882-14-511] [PMID: 25524718]
[3]
Ainehchi, N.; Farshbaf-Khalili, A.; Ghasemzadeh, A.; Hamdi, K.; Khaki, A.; Ouladsahebmadarek, E.; Delazar, A.; Bakhtyari, F.; Mazandarani, M. The effect of herbal medicine supplementation on clinical and para-clinical outcomes in women with PCOS: A systematic review and meta-analysis. Int. J. Women’s Health Reprod. Sci., 2019, 7(4), 423-433.
[http://dx.doi.org/10.15296/ijwhr.2019.72]
[4]
Pachiappan, S.; Matheswaran, S.; Pushkalai, P.; Saravanan, G.M. Medicinal plants for polycystic ovary syndrome: A review of phytomedicine research. Int. J. Herb. Med., 2017, 5(2), 78-80.
[5]
Arentz, S.; Smith, CA.; Abbott, JA.; Bensoussan, A. A survey of the use of complementary medicine by a self-selected community group of Australian women with polycystic ovary syndrome. BMC Complement. Altern. Med., 2014, 14, 472.
[http://dx.doi.org/10.1186/1472-6882-14-472]
[6]
Howe, E. Understanding and Managing Polycystic Ovarian Syndrome; PCOS, 2015, pp. 1-44.
[7]
Kitzinger, C.; Willmott, J. ‘The thief of womanhood’: Women’s experience of polycystic ovarian syndrome. Soc. Sci. Med., 2002, 54(3), 349-361.
[http://dx.doi.org/10.1016/S0277-9536(01)00034-X] [PMID: 11824912]
[8]
Peyrin-Biroulet, L.; Sandborn, W.; Sands, B.E.; Reinisch, W.; Bemelman, W.; Bryant, R.V.; D’Haens, G.; Dotan, I.; Dubinsky, M.; Feagan, B.; Fiorino, G.; Gearry, R.; Krishnareddy, S.; Lakatos, P.L.; Loftus, E.V., Jr; Marteau, P.; Munkholm, P.; Murdoch, T.B.; Ordás, I.; Panaccione, R.; Riddell, R.H.; Ruel, J.; Rubin, D.T.; Samaan, M.; Siegel, C.A.; Silverberg, M.S.; Stoker, J.; Schreiber, S.; Travis, S.; Van Assche, G.; Danese, S.; Panes, J.; Bouguen, G.; O’Donnell, S.; Pariente, B.; Winer, S.; Hanauer, S.; Colombel, J.F. Selecting therapeutic targets in inflammatory bowel disease (STRIDE): Determining therapeutic goals for treat-to-target. Am. J. Gastroenterol., 2015, 110(9), 1324-1338.
[http://dx.doi.org/10.1038/ajg.2015.233] [PMID: 26303131]
[9]
Ong, M.; Peng, J.; Jin, X.; Qu, X. Chinese herbal medicine for the optimal management of polycystic ovary syndrome. Am. J. Chin. Med., 2017, 45(3), 405-422.
[http://dx.doi.org/10.1142/S0192415X17500252] [PMID: 28359195]
[10]
El Hayek, S.; Bitar, L.; Hamdar, L.H.; Mirza, F.G.; Daoud, G. Poly cystic ovarian syndrome: An updated overview. Front. Physiol., 2016, 7(APR), 124.
[http://dx.doi.org/10.3389/fphys.2016.00124] [PMID: 27092084]
[11]
Timpatanapong, P.; Rojanasakul, A. Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne. J. Dermatol., 1997, 24, 223-229.
[12]
Gibson-Helm, M.E.; Lucas, I.M.; Boyle, J.A.; Teede, H.J. Women’s experiences of polycystic ovary syndrome diagnosis. Fam. Pract., 2014, 31(5), 545-549.
[http://dx.doi.org/10.1093/fampra/cmu028] [PMID: 24925927]
[13]
Kashani, L.; Akhondzadeh, S. Herbal medicine in the treatment of polycystic ovary syndrome. Faslnamah-i Giyahan-i Daruyi, 2016, 15(59), 1-5.
[14]
Dunaif, A.; Fauser, B.C.J.M. Renaming PCOS-a two-state solution. J. Clin. Endocrinol. Metab., 2013, 98(11), 4325-4328.
[http://dx.doi.org/10.1210/jc.2013-2040] [PMID: 24009134]
[15]
Hacıhanefioglu, B. Polycystic ovary syndrome nomenclature: Chaos? Fertil. Steril., 2000, 73(6), 1261-1262.
[http://dx.doi.org/10.1016/S0015-0282(00)00525-2] [PMID: 10856497]
[16]
Balen, A. The pathophysiology of polycystic ovary syndrome: Trying to understand PCOS and its endocrinology. Best Pract. Res. Clin. Obstet. Gynaecol., 2004, 18(5), 685-706.
[http://dx.doi.org/10.1016/j.bpobgyn.2004.05.004]
[17]
Abasian, Z.; Rostamzadeh, A.; Mohammadi, M.; Hosseini, M.; Rafieian-kopaei, M. A review on role of medicinal plants in polycystic ovarian syndrome: Pathophysiology, neuroendocrine signaling, therapeutic status and future prospects. Middle East Fertil. Soc. J., 2018, 23(4), 255-262.
[http://dx.doi.org/10.1016/j.mefs.2018.04.005]
[18]
Arentz, S.; Smith, CA.; Abbott, J.; Fahey, P.; Cheema, BS.; Bensoussan, A. Combined lifestyle and herbal medicine in overweight women with polycystic ovary syndrome (PCOS): A randomized controlled trial. Phytother. Res., 2017, 31(9), 1330-1340.
[19]
March, W.A.; Moore, V.M.; Willson, K.J.; Phillips, D.I.W.; Norman, R.J.; Davies, M.J. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum. Reprod., 2010, 25(2), 544-551.
[http://dx.doi.org/10.1093/humrep/dep399] [PMID: 19910321]
[20]
Grant, P.; Ramasamy, S. An update on plant derived anti-androgens. Int. J. Endocrinol. Metab., 2012, 10(2), 497-502.
[http://dx.doi.org/10.5812/ijem.3644] [PMID: 23843810]
[21]
Diamanti-kandarakis, E.; Kandarakis, H.; Legro, R.S. Role of genes and environment in the etiology of PCOS. Endocrine, 2006, 30(1), 19-26.
[22]
Sawant, A.A.; Patil, S.; Shah, S. Review on PCOD/PCOS & its treatment in different medicinal systems - allopathy, Ayurveda. Homeopathy, 2017, 1(1), 1-16.
[23]
El-Saber Batiha, G.; Magdy Beshbishy, A.; El-Mleeh, A.; Abdel-Daim, M.M.; Prasad Devkota, H. Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L. (Fabaceae). Biomolecules, 2020, 10(3), 352.
[http://dx.doi.org/10.3390/biom10030352] [PMID: 32106571]
[24]
Matalliotakis, I.; Kourtis, A.; Koukoura, O.; Panidis, D. Polycystic ovary syndrome: Etiology and pathogenesis. Arch. Gynecol. Obstet., 2006, 274(4), 187-197.
[http://dx.doi.org/10.1007/s00404-006-0171-x] [PMID: 16685527]
[25]
Barth, J.H.; Catalan, J.; Cherry, C.A.; Day, A. Psychological morbidity in women referred treatment of hirsutism. J. Psychosom. Res., 1993, 37(6), 615-619.
[26]
Adams, J.; Polson, D.W.; Franks, S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br. Med. J., 1986, 293(6552), 956-957.
[http://dx.doi.org/10.1136/bmj.293.6543.355]
[27]
Teede, H.; Gibson-Helm, M.; Norman, R.J.; Boyle, J. Polycystic ovary syndrome: Perceptions and attitudes of women and primary health care physicians on features of PCOS and renaming the syndrome. J. Clin. Endocrinol. Metab., 2014, 99(1), E107-E111.
[http://dx.doi.org/10.1210/jc.2013-2978] [PMID: 24178791]
[28]
Hardiman, P.; Pillay, O.S.; Atiomo, W. Polycystic ovary syndrome and endometrial carcinoma. Lancet, 2003, 361(9371), 1810-1812.
[http://dx.doi.org/10.1016/S0140-6736(03)13409-5] [PMID: 12781553]
[29]
Glintborg, D.; Andersen, M. An update on the pathogenesis, inflammation, and metabolism in hirsutism and polycystic ovary syndrome. Gynecol. Endocrinol., 2010, 26(4), 281-296.
[http://dx.doi.org/10.3109/09513590903247873]
[30]
Archer, JS.; Chang, R.J. Hirsutism and acne in polycystic ovary syndrome. Best Pract. Res. Clin. Obstet. Gynaecol., 2004, 18(5), 737-754.
[http://dx.doi.org/10.1016/j.bpobgyn.2004.05.007]
[31]
Khomami, M.B.; Tehrani, F.R.; Hashemi, S. Of PCOS symptoms, hirsutism has the most significant impact on the quality of life of Iranian women. PLoS One, 2015, 10(4), e0123608.
[32]
De Leo, V.; Musacchio, M.C.; Cappelli, V.; Massaro, M.G.; Morgante, G.; Petraglia, F. Genetic, hormonal and metabolic aspects of PCOS: An update. Reprod. Biol. Endocrinol., 2016, 14(1), 38.
[http://dx.doi.org/10.1186/s12958-016-0173-x] [PMID: 27423183]
[33]
Synder, D.S. The effect of flaxseed supplementation on hormonal levels associated with polycystic ovarian syndrome: A case study. Curr. Top. Nutraceutical Res., 2007, 5(4), 177-181.
[34]
By, P.; Sanskriti, D.E.V.; Shrivastava, V.; Batham, L.; Mishra, S.; Mishra, A. Management of symptoms associated with Obsessive-Compulsive Disorder (OCD) and PolyCystic Ovarian Disease (PCOD) through an integrated approach including yagya therapy. Interdisciplin. J. Yagya Res., 2019, 2(1), 39-51.
[35]
Van Onselen, J. Hirsutism: Causes and treatment for women Br. J.Nurs., 2011, 20(16), 985.(990) 988, 990
[http://dx.doi.org/10.12968/bjon.2011.20.16.985] [PMID: 22067491]
[36]
Lim, S.S.; Davies, M.J.; Norman, R.J.; Moran, L.J. Overweight, obesity and central obesity in women with polycystic ovary syndrome: A systematic review and meta-analysis. Hum. Reprod. Update, 2012, 18(6), 618-637.
[http://dx.doi.org/10.1093/humupd/dms030] [PMID: 22767467]
[37]
Conn, J.J.; Jacobs, H.S.; Conway, G.S. The prevalence of polycystic ovaries in women with type 2 diabetes mellitus. Clin. Endocrinol., 2000, 52(1), 81-86.
[http://dx.doi.org/10.1046/j.1365-2265.2000.00884.x] [PMID: 10651757]
[38]
Yadav, K.; Ghadge, P.; Langeh, A.; Kalbhare, S.; Phadtare, P.; Bhoite, R. A review on herbal medicinal plant for treatment of polycystic ovarian syndrome (PCOS). Asian J. Pharmaceut. Res. Develop., 2020, 8(4), 83-87.
[39]
Goldzieher, J.W.; Green, J.A. The polycystic ovary. I. Clinical and histologic features. J. Clin. Endocrinol. Metab., 1962, 22(3), 325-338.
[http://dx.doi.org/10.1210/jcem-22-3-325] [PMID: 13899931]
[40]
Fauser, B.C.J.M.; Tarlatzis, B.C.; Rebar, R.W.; Legro, R.S.; Balen, A.H.; Lobo, R.; Carmina, H.; Chang, R.J.; Yildiz, B.O.; Laven, J.S.E.; Boivin, J.; Petraglia, F.; Wijeyeratne, C.N.; Norman, R.J.; Dunaif, A.; Franks, S.; Wild, R.A.; Dumesic, D.; Barnhart, K. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS). Hum. Reprod., 2012, 27(1), 14-24.
[http://dx.doi.org/10.1093/humrep/der396] [PMID: 22147920]
[41]
Knochenhauer, E.S.; Key, T.J.; Kahsar-Miller, M.; Waggoner, W.; Boots, L.R.; Azziz, R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study. J. Clin. Endocrinol. Metab., 1998, 83(9), 3078-3082.
[http://dx.doi.org/10.1210/jc.83.9.3078] [PMID: 9745406]
[42]
Teede, H.J.; Misso, M.L.; Deeks, A.A.; Moran, L.J.; Stuckey, B.G.A.; Wong, J.L.A.; Norman, R.J.; Costello, M.F. Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline. Med. J. Aust., 2011, 195(6), S65-S112.
[PMID: 21929505]
[43]
Moini Jazani, A.; Nasimi Doost Azgomi, H.; Nasimi Doost Azgomi, A.; Nasimi Doost Azgomi, R. A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS). Daru, 2019, 27(2), 863-877.
[http://dx.doi.org/10.1007/s40199-019-00312-0] [PMID: 31741280]
[44]
Merhi, Z.; Kandaraki, E.A.; Diamanti-Kandarakis, E. Implications and future perspectives of AGEs in PCOS pathophysiology. Trends Endocrinol. Metab., 2019, 30(3), 150-162.
[http://dx.doi.org/10.1016/j.tem.2019.01.005] [PMID: 30712978]
[45]
Kwon, C.Y.; Cho, I.H.; Park, K.S. Therapeutic effects and mechanisms of herbal medicines for treating polycystic ovary syndrome: A review. Front. Pharmacol., 2020, 11(August), 1192.
[http://dx.doi.org/10.3389/fphar.2020.01192] [PMID: 32903374]
[46]
Marx, T.L.; Mehta, A.E. Polycystic ovary syndrome: Pathogenesis and treatment over the short and long term. Cleve. Clin. J. Med., 2003, 70(1), 31-33, 36-41, 45.
[http://dx.doi.org/10.3949/ccjm.70.1.31] [PMID: 12549723]
[47]
Mehraban, M.; Jelodar, G.; Rahmanifar, F. A combination of spearmint and flaxseed extract improved endocrine and histomorphology of ovary in experimental PCOS. J. Ovarian Res., 2020, 13(1), 1-8.
[http://dx.doi.org/10.1186/s13048-020-00633-8]
[48]
Grant, P. Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytother. Res., 2010, 24(2), 186-188.
[http://dx.doi.org/10.1002/ptr.2900] [PMID: 19585478]
[49]
Choi, J.H.; Jang, M.; Kim, E.J.; Lee, M.J.; Park, K.S.; Kim, S.H. In, J.G.; Kwak, Y.S.; Park, D.H.; Cho, S.S.; Nah, S.Y.; Cho, I.H.; Bae, C.S. Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its antiinflammatory and antioxidant activities. J. Ginseng Res., 2020, 44(6), 790-798.
[http://dx.doi.org/10.1016/j.jgr.2019.08.007] [PMID: 33192122]
[50]
Phipps, W.R.; Martini, M.C.; Lampe, J.W.; Slavin, J.L.; Kurzer, M.S. Effect of flax seed ingestion on the menstrual cycle. J. Clin. Endocrinol. Metab., 1993, 77(5), 1215-1219.
[PMID: 8077314]
[51]
Lampe, JW; Kurzer, S Urinary women lignan and consuming isoflavonoid excretion flaxseed in premenopausal. 2018, 122-8.
[52]
Ashkar, F.; Rezaei, S.; Salahshoornezhad, S.; Vahid, F.; Gholamalizadeh, M.; Dahka, S.M.; Doaei, S. The Role of medicinal herbs in treatment of insulin resistance in patients with polycystic ovary syndrome: A literature review. Biomol. Concepts, 2020, 11(1), 57-75.
[http://dx.doi.org/10.1515/bmc-2020-0005]
[53]
Choi, H.C.; Kim, S.J.; Son, K.Y.; Oh, B.J.; Cho, B.L. Metabolic effects of Aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: Randomized controlled trial. Nutrition, 2013, 29(9), 1110-1114.
[http://dx.doi.org/10.1016/j.nut.2013.02.015] [PMID: 23735317]
[54]
Jain, SG.; Puri, S.; Misra, A.; Gulati, S.; Mani, K. Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome: A randomized double -blind control trial. Lipids Health Dis., 2017, 16113.
[55]
Armanini, D.; Jung, M.; Fiore, C.; Bonanni, G.; Scaroni, C.; Sartorato, P. Licorice reduces serum testosterone in healthy women. Steroids, 2004, 69(11-12), 763-6.
[http://dx.doi.org/10.1016/j.steroids.2004.09.005]
[56]
Swaroop, A.; Jaipuriar, A.S.; Gupta, S.K.; Bagchi, M.; Kumar, P. Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst TM) in Polycystic Ovary Syn- drome; (PCOS). Int. Med. Sci., 2015, (10), 825-831.
[57]
Pournaderi, P.S.; Yaghmaei, P.; Seyed Hossein Hejazi, Z.; Khodaei, HR. The effects of ginger extract on cyclooxygenase-2 gene expression in polycystic ovary syndrome rats. J. Bas. Res. Med. Sci., 2019, 6(4), 37-44.
[58]
Nampoothiri, L.P.; Desai, B.N.; Maharjan, R.H. Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model. Pharmacogn. Res., 2012, 4(2), 109-115.
[http://dx.doi.org/10.4103/0974-8490.94736] [PMID: 22518083]
[59]
Wang, J.G.; Anderson, R.A.; Graham, G.M., III; Chu, M.C.; Sauer, M.V.; Guarnaccia, M.M.; Lobo, R.A. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: A pilot study. Fertil. Steril., 2007, 88(1), 240-243.
[http://dx.doi.org/10.1016/j.fertnstert.2006.11.082] [PMID: 17296187]
[60]
Kort, D.H.; Lobo, R.A. Preliminary evidence that cinnamon improves menstrual cyclicity in women with polycystic ovary syndrome: A randomized controlled trial. Am. J. Obstet. Gynecol., 2014, 211(5), 487.e1-487.e6.
[http://dx.doi.org/10.1016/j.ajog.2014.05.009] [PMID: 24813595]
[61]
Borzoei, A.; Rafraf, M.; Niromanesh, S.; Farzadi, L.; Narimani, F.; Doostan, F. Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome. J. Tradit. Complement. Med., 2018, 8(1), 128-133.
[http://dx.doi.org/10.1016/j.jtcme.2017.04.008] [PMID: 29322000]
[62]
Maryam Hassanzadeh, B.; Seyed Ahmad, E.; Nezhat, M.; Habib Allah, E.; Mahmoud, M.; Amir Hooshang Mohammad, P. Evaluation of fenugreek (Trigonella foenum-graceum L.), effects seeds extract on insulin resistance in women with polycystic ovarian syndrome. Iran. J. Pharm. Res., 2013, 12(2), 475-481.
[63]
Rafraf, M.; Zemestani, M.; Asghari-Jafarabadi, M. Effectiveness of chamomile tea on glycemic control and serum lipid profile in patients with type 2 diabetes. J. Endocrinol. Invest., 2015, 38(2), 163-170.
[http://dx.doi.org/10.1007/s40618-014-0170-x] [PMID: 25194428]
[64]
Hammad, M.; Syed Sulaiman, S.; Aziz, N.; Mohamed Noor, D. Prescribing statins among patients with type 2 diabetes: The clinical gap between the guidelines and practice. J. Res. Med. Sci., 2019, 24(1), 15.
[http://dx.doi.org/10.4103/jrms.JRMS_100_18] [PMID: 30988683]
[65]
Sadeghi Ataabadi, M.; Alaee, S.; Bagheri, M.J.; Bahmanpoor, S. Role of essential oil of Mentha spicata (spearmint) in addressing reverse hormonal and folliculogenesis disturbances in a polycystic ovarian syndrome in a rat model. Adv. Pharm. Bull., 2017, 7(4), 651-654.
[http://dx.doi.org/10.15171/apb.2017.078] [PMID: 29399556]
[66]
Mehran, M.; Masoum, S.; Memarzadeh, M. Microencapsulation of Mentha spicata essential oil by spray drying: Optimization, characterization, release kinetics of essential oil from microcapsules in food models. Ind. Crops Prod., 2020, 154(154), 112694.
[http://dx.doi.org/10.1016/j.indcrop.2020.112694]
[67]
Faghihi, G.; Iraji, F.; Abtahi-Naeini, B.; Saffar, B.; Saffaei, A.; Pourazizi, M. Complementary therapies for idiopathic hirsutism: Topical licorice as promising option. Evidence-based Complement Altern Med, 2015, 2015, 659041.
[68]
Armanini, D.; Castello, R.; Scaroni, C.; Bonanni, G.; Faccini, G.; Pellati, D.; Bertoldo, A.; Fiore, C.; Moghetti, P. Treatment of polycystic ovary syndrome with spironolactone plus licorice. Eur. J. Obstet. Gynecol. Reprod. Biol., 2007, 131(1), 61-67.
[http://dx.doi.org/10.1016/j.ejogrb.2006.10.013] [PMID: 17113210]
[69]
Yang, H.; Kim, H.J.; Pyun, B.J.; Lee, H.W. Licorice ethanol extract improves symptoms of polycytic ovary syndrome in Letrozole-induced female rats. Integr. Med. Res., 2018, 7(3), 264-270.
[http://dx.doi.org/10.1016/j.imr.2018.05.003] [PMID: 30271715]

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