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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Review Article

Review on Diabetes Mellitus: An Insight into the Current Scenarios, the Challenges of Therapy, and Application of Traditional Drugs

Author(s): Ashwini Kumar Mishra, Mukesh Pandey, Arzoo Pannu, Hitesh Kumar Dewangan and P.K. Sahoo*

Volume 10, Issue 3, 2024

Published on: 25 May, 2023

Article ID: e010523216399 Pages: 22

DOI: 10.2174/2215083810666230501212125

Price: $65

Abstract

Diabetes mellitus, an epidemic of the 21st century, is listed as one of the top ten causes of death around the world by the World Health Organization and is a complicated disease to deal with. Medically, a metabolic disorder characterized by elevated blood glucose levels and altered metabolism of biological macromolecules, mainly carbohydrates. Diabetes mellitus has a worldwide prevalence, and populations of all high, middle, as well as low-income countries, are affected by it. More than 400 million persons are currently living with diabetes. Many risk factors, such as lack of exercise, irregular diet, drinking, and smoking habits, as well as genetic factors, also contribute to the increased incidence of diabetes mellitus in the modern era. The conventional therapies for diabetes are based on insulin, insulin analogues, peptides, and oral hypoglycemics. The primary objective is to lower the elevated blood glucose levels and manage the distress to enhance the quality of life of the patient. The management of diabetes is very crucial to avoid complications having serious consequences such as the extra economic burden due to these complications. Conventional drug therapy has its own adverse effects, and its timely availability and cost are still an issue in many low and middle-income countries. Diabetes mellitus has been reported in various ancient kinds of literature along with various natural remedies (plants/herbals) useful in it. These plant-based remedies offer the benefits of lesser or no adverse effects, easy availability due to natural abundance, and low cost. Therefore, extensive research work is carried out in the past few decades to identify and understand the underlying principles of plant-based/herbal medicines to develop new potential lead molecules and a relatively safer, easily available and more economical alternative treatment therapy for diabetes mellitus.

Keywords: Diabetes mellitus, pathophysiology, health, herbal treatment, epidemic, treatment theraphy.

[1]
Ahmed AM. History of diabetes mellitus. Saudi Med J 2002; 23(4): 373-8.
[PMID: 11953758]
[2]
Upathaya V, Kamla P. Ayurvedic approach to diabetes mellitus and its management by indigenous resources Diabetes Mellitus in developing countries. New Delhi: Interprint 1984; pp. 375-7.
[3]
Sridharan K, Mohan R, Ramaratnam S, Panneerselvam D. Ayurvedic treatments for diabetes mellitus. Cochrane Database Syst Rev 2011; 12(12): CD008288.
[PMID: 22161426]
[4]
Harsh M. The Endocrine system Text Book of Pathology. (5th ed.). J P Brothers 2005; pp. 818-28.
[5]
Harikumar K, Kumar BK, Hemalatha GJ, Kumar MB, Lado SF. A review on diabetes mellitus. Int J Novel Trends Pharm Sci 2015; 5(3): 201-17.
[6]
World health organization. Global health estimates 2016: Disease burden by cause, age, sex, by country and by region. 2018; 2000-16.
[7]
World Health Organization. Global report on diabetes 2016.
[8]
International Diabetes Federation.IDF Diabetes Atlas. (8th ed.), Belgium: International Diabetes Federation Brussels 2017.
[9]
Kharroubi AT, Darwish HM. Diabetes mellitus: The epidemic of the century. World J Diabetes 2015; 6(6): 850-67.
[http://dx.doi.org/10.4239/wjd.v6.i6.850] [PMID: 26131326]
[10]
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2013; 36 (Suppl 1): S67-74.
[PMID: 23264425]
[11]
Kropff J, Selwood MP, McCarthy MI, Farmer AJ, Owen KR. Prevalence of monogenic diabetes in young adults: A community-based, cross-sectional study in Oxfordshire, UK. Diabetologia 2011; 54(5): 1261-3.
[http://dx.doi.org/10.1007/s00125-011-2090-z] [PMID: 21350841]
[12]
Thomas ERA, Brackenridge A, Kidd J, et al. Diagnosis of monogenic diabetes: 10‐Year experience in a large multi‐ethnic diabetes center. J Diabetes Investig 2016; 7(3): 332-7.
[http://dx.doi.org/10.1111/jdi.12432] [PMID: 27330718]
[13]
Gandica RG, Chung WK, Deng L, Goland R, Gallagher MP. Identifying monogenic diabetes in a pediatric cohort with presumed type 1 diabetes. Pediatr Diabetes 2015; 16(3): 227-33.
[http://dx.doi.org/10.1111/pedi.12150] [PMID: 25082184]
[14]
Murphy R, Ellard S, Hattersley AT. Clinical implications of a molecular genetic classification of monogenic β-cell diabetes. Nat Clin Pract Endocrinol Metab 2008; 4(4): 200-13.
[http://dx.doi.org/10.1038/ncpendmet0778] [PMID: 18301398]
[15]
Guthrie RA, Guthrie DW. Pathophysiology of diabetes mellitus. Crit Care Nurs Q 2004; 27(2): 113-25.
[http://dx.doi.org/10.1097/00002727-200404000-00003] [PMID: 15137354]
[16]
Slavin J, Carlson J. Carbohydrates. Adv Nutr 2014; 5(6): 760-1.
[http://dx.doi.org/10.3945/an.114.006163] [PMID: 25398736]
[17]
Cohen P, Spiegelman BM. Cell biology of fat storage. Mol Biol Cell 2016; 27(16): 2523-7.
[http://dx.doi.org/10.1091/mbc.e15-10-0749] [PMID: 27528697]
[18]
Chang L, Chiang SH, Saltiel AR. Insulin signaling and the regulation of glucose transport. Mol Med 2004; 10(7-12): 65-71.
[http://dx.doi.org/10.2119/2005-00029.Saltiel] [PMID: 16307172]
[19]
Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 414(6865): 799-806.
[http://dx.doi.org/10.1038/414799a] [PMID: 11742412]
[20]
Devendra D, Liu E, Eisenbarth GS. Type 1 diabetes: Recent developments. BMJ 2004; 328(7442): 750-4.
[http://dx.doi.org/10.1136/bmj.328.7442.750] [PMID: 15044291]
[21]
Vermeulen I, Weets I, Asanghanwa M, et al. Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age. Diabetes Care 2011; 34(8): 1760-5.
[http://dx.doi.org/10.2337/dc10-2268] [PMID: 21715527]
[22]
Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. Pediatr Diabetes 2009; 10(12) (Suppl. 12): 3-12.
[http://dx.doi.org/10.1111/j.1399-5448.2009.00568.x] [PMID: 19754613]
[23]
Dabelea D, Mayer-Davis EJ, Saydah S, et al. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 2014; 311(17): 1778-86.
[http://dx.doi.org/10.1001/jama.2014.3201] [PMID: 24794371]
[24]
Imagawa A, Hanafusa T, Miyagawa JI, Matsuzawa Y. A proposal of three distinct subtypes of type 1 diabetes mellitus based on clinical and pathological evidence. Ann Med 2000; 32(8): 539-43.
[http://dx.doi.org/10.3109/07853890008998833] [PMID: 11127931]
[25]
Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. N Engl J Med 2000; 342(5): 301-7.
[http://dx.doi.org/10.1056/NEJM200002033420501] [PMID: 10655528]
[26]
Guarnotta V, Vigneri E, Pillitteri G, Ciresi A, Pizzolanti G, Giordano C. Higher cardiometabolic risk in idiopathic versus autoimmune type 1 diabetes: A retrospective analysis. Diabetol Metab Syndr 2018; 10(1): 40.
[http://dx.doi.org/10.1186/s13098-018-0341-6] [PMID: 29760789]
[27]
Ahrén B, Corrigan CB. Intermittent need for insulin in a subgroup of diabetic patients in Tanzania. Diabet Med 1985; 2(4): 262-4.
[PMID: 2951079]
[28]
Gavin JR III, Alberti KG, Davidson MB, DeFronzo RA. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20(7): 1183-97.
[http://dx.doi.org/10.2337/diacare.20.7.1183] [PMID: 9203460]
[29]
Sacks DB, McDonald JM. The pathogenesis of type II diabetes mellitus. A polygenic disease. Am J Clin Pathol 1996; 105(2): 149-56.
[http://dx.doi.org/10.1093/ajcp/105.2.149] [PMID: 8607437]
[30]
Kahn CR, Vicent D, Doria A. Genetics of non-insulin-dependent (type-II) diabetes mellitus. Annu Rev Med 1996; 47(1): 509-31.
[http://dx.doi.org/10.1146/annurev.med.47.1.509] [PMID: 8712800]
[31]
Winckler W, Weedon MN, Graham RR, et al. Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 2007; 56(3): 685-93.
[http://dx.doi.org/10.2337/db06-0202] [PMID: 17327436]
[32]
Fajans SS, Bell GI, Polonsky KS. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 2001; 345(13): 971-80.
[http://dx.doi.org/10.1056/NEJMra002168] [PMID: 11575290]
[33]
Hod M, Kapur A, Sacks DA, et al. The International Federation of Gynecology and Obstetrics (FIGO) Initiative on gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and care Int J. Gynecol Obstet 2015; 131(3): S173-211.
[34]
Ryffel GU. Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: Functional and pathological consequences. J Mol Endocrinol 2001; 27(1): 11-29.
[http://dx.doi.org/10.1677/jme.0.0270011] [PMID: 11463573]
[35]
O’Sullivan JB. Gestational Diabetes. N Engl J Med 1961; 264(21): 1082-5.
[http://dx.doi.org/10.1056/NEJM196105252642104] [PMID: 13730123]
[36]
O’Sullivan JB, Mahan CM. Criteria for the oral glucose tolerance test in pregnancy. Diabetes 1964; 13: 278-85.
[PMID: 14166677]
[37]
Carrington ER, Shuman CR, Reardon HS. Evaluation of the prediabetic state during pregnancy. Obstet Gynecol 1957; 9(6): 664-9.
[http://dx.doi.org/10.1097/00006250-195706000-00008] [PMID: 13431126]
[38]
Larsen S. Diabetes mellitus secondary to chronic pancreatitis. Dan Med Bull 1993; 40(2): 153-62.
[PMID: 8495594]
[39]
Resmini E, Minuto F, Colao A, Ferone D. Secondary diabetes associated with principal endocrinopathies: The impact of new treatment modalities. Acta Diabetol 2009; 46(2): 85-95.
[http://dx.doi.org/10.1007/s00592-009-0112-9] [PMID: 19322513]
[40]
Herth FJF, Bramlage P, Müller-Wieland D. Current perspectives on the contribution of inhaled corticosteroids to an increased risk for diabetes onset and progression in patients with chronic obstructive pulmonary disease. Respiration 2015; 89(1): 66-75.
[http://dx.doi.org/10.1159/000368371] [PMID: 25471093]
[41]
Bozkurt O, de Boer A, Grobbee DE, et al. Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics. Am J Hypertens 2009; 22(5): 545-51.
[http://dx.doi.org/10.1038/ajh.2009.38] [PMID: 19247266]
[42]
Brunton L, Parker K, Bluementhal A, Buxton L. Goodman & Gilmann’s Manual of Pharmacology and Therapeutics. (12th edition..). McGraw-Hill publication 2006; pp. 1619-21.
[43]
World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation. 2006.
[44]
Thanabalasingham G, Owen KR. Diagnosis and management of maturity onset diabetes of the young (MODY). BMJ 2011; 343(oct19 3): d6044.
[http://dx.doi.org/10.1136/bmj.d6044] [PMID: 22012810]
[45]
Kolluru GK, Bir SC, Kevil CG. Endothelial dysfunction and diabetes: Effects on angiogenesis, vascular remodeling, and wound healing. Int J Vasc Med 2012; 2012: 1-30.
[http://dx.doi.org/10.1155/2012/918267] [PMID: 22611498]
[46]
Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev 2013; 93(1): 137-88.
[http://dx.doi.org/10.1152/physrev.00045.2011] [PMID: 23303908]
[47]
Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci 2014; 11(11): 1185-200.
[http://dx.doi.org/10.7150/ijms.10001] [PMID: 25249787]
[48]
Umpierrez G, Korytkowski M. Diabetic emergencies-ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia. Nat Rev Endocrinol 2016; 12(4): 222-32.
[http://dx.doi.org/10.1038/nrendo.2016.15] [PMID: 26893262]
[49]
Cade WT. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther 2008; 88(11): 1322-35.
[http://dx.doi.org/10.2522/ptj.20080008] [PMID: 18801863]
[50]
Sarwar N, Gao P, Seshasai SR, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies. Lancet 2010; 375(9733): 2215-22.
[http://dx.doi.org/10.1016/S0140-6736(10)60484-9] [PMID: 20609967]
[51]
Danaei G, Lawes CMM, Vander Hoorn S, Murray CJL, Ezzati M. Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: Comparative risk assessment. Lancet 2006; 368(9548): 1651-9.
[http://dx.doi.org/10.1016/S0140-6736(06)69700-6] [PMID: 17098083]
[52]
Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema: Pathophysiology, screening, and novel therapies. Diabetes Care 2003; 26(9): 2653-64.
[http://dx.doi.org/10.2337/diacare.26.9.2653] [PMID: 12941734]
[53]
Bonovas S, Peponis V, Filioussi K. Diabetes mellitus as a risk factor for primary open-angle glaucoma: A meta-analysis. Diabet Med 2004; 21(6): 609-14.
[http://dx.doi.org/10.1111/j.1464-5491.2004.01173.x] [PMID: 15154948]
[54]
Bron AJ, Brown NAP, Harding JJ, Ganea E. The lens and cataract in diabetes. Int Ophthalmol Clin 1998; 38(2): 37-67.
[http://dx.doi.org/10.1097/00004397-199803820-00005] [PMID: 9604737]
[55]
Priem HA. Diabetes mellitus and the eye. Acta Clin Belg 2004; 59(5): 237-40.
[http://dx.doi.org/10.1179/acb.2004.034] [PMID: 15641391]
[56]
Atkins RC, Briganti EM, Lewis JB, et al. Proteinuria reduction and progression to renal failure in patients with type 2 diabetes mellitus and overt nephropathy. Am J Kidney Dis 2005; 45(2): 281-7.
[http://dx.doi.org/10.1053/j.ajkd.2004.10.019] [PMID: 15685505]
[57]
Blanco S, Vaquero M, Gómezguerrero C, López D, Egido J, Romero R. Potential role of angiotensin-converting enzyme inhibitors and statins on early podocyte damage in a model of type 2 diabetes mellitus, obesity, and mild hypertension. Am J Hypertens 2005; 18(4): 557-65.
[http://dx.doi.org/10.1016/j.amjhyper.2004.10.034] [PMID: 15831368]
[58]
Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA 2005; 293(2): 217-28.
[http://dx.doi.org/10.1001/jama.293.2.217] [PMID: 15644549]
[59]
Malavige LS, Levy JC. Erectile dysfunction in diabetes mellitus. J Sex Med 2009; 6(5): 1232-47.
[http://dx.doi.org/10.1111/j.1743-6109.2008.01168.x] [PMID: 19210706]
[60]
Ship JA. Diabetes and oral health. J Am Dent Assoc 2003; 134(Spec No): 4S-10S.
[http://dx.doi.org/10.14219/jada.archive.2003.0367] [PMID: 18196667]
[61]
Al-Maskari AY, Al-Maskari MY, Al-Sudairy S. Oral manifestations and complications of diabetes mellitus: A review. Sultan Qaboos Univ Med J 2011; 11(2): 179-86.
[PMID: 21969888]
[62]
Abdulrahman KA. DPHC A. Diabetes mellitus and its oral complications: A brief review. Pak Oral Dent J 2006; 26: 97-100.
[63]
Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E, Viñas M, López-López J. Oral manifestations of diabetes mellitus. A systematic review. Med Oral Patol Oral Cir Bucal 2017; 22(5): 0.
[http://dx.doi.org/10.4317/medoral.21655] [PMID: 28809366]
[64]
Quianzon CC, Cheikh I. History of insulin. J Community Hosp Intern Med Perspect 2012; 2(2): 18701.
[http://dx.doi.org/10.3402/jchimp.v2i2.18701] [PMID: 23882369]
[65]
Bliss M. The history of insulin. Diabetes Care 1993; 16(3) (Suppl. 3): 4-7.
[http://dx.doi.org/10.2337/diacare.16.3.4] [PMID: 8299476]
[66]
Kruger DF, Gloster MA. Pramlintide for the treatment of insulin-requiring diabetes mellitus: Rationale and review of clinical data. Drugs 2004; 64(13): 1419-32.
[http://dx.doi.org/10.2165/00003495-200464130-00003] [PMID: 15212559]
[67]
Kleppinger EL, Vivian EM. Pramlintide for the treatment of diabetes mellitus. Ann Pharmacother 2003; 37(7-8): 1082-9.
[http://dx.doi.org/10.1345/aph.1C387] [PMID: 12841822]
[68]
Ryan GJ, Jobe LJ, Martin R. Pramlintide in the treatment of type 1 and type 2 diabetes mellitus. Clin Ther 2005; 27(10): 1500-12.
[http://dx.doi.org/10.1016/j.clinthera.2005.10.009] [PMID: 16330288]
[69]
Jones MC. Therapies for diabetes: Pramlintide and exenatide. Am Fam Physician 2007; 75(12): 1831-5.
[PMID: 17619527]
[70]
Kolterman OG, Kim DD, Shen L, et al. Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus. Am J Health Syst Pharm 2005; 62(2): 173-81.
[http://dx.doi.org/10.1093/ajhp/62.2.173] [PMID: 15700891]
[71]
Dungan K, Buse JB. Glucagon-like peptide 1-based therapies for type 2 diabetes: A focus on exenatide. Clin Diabetes 2005; 23(2): 56-62.
[http://dx.doi.org/10.2337/diaclin.23.2.56]
[72]
Keegan A. Weak sales lead to Exubera’s market withdrawal. Doc News 2007; 4(12): 5.
[73]
Siekmeier R, Scheuch G. Inhaled insulin--does it become reality? J Physiol Pharmacol 2008; 59(6) (Suppl. 6): 81-113.
[PMID: 19218634]
[74]
Tripathi P, Pandey A, Pandey R, Srivatava R, Goswami S. Alternative therapies useful in the management of diabetes: A systematic review. J Pharm Bioallied Sci 2011; 3(4): 504-12.
[http://dx.doi.org/10.4103/0975-7406.90103] [PMID: 22219583]
[75]
Roberts KT. The potential of fenugreek (Trigonella foenum-graecum) as a functional food and nutraceutical and its effects on glycemia and lipidemia. J Med Food 2011; 14(12): 1485-9.
[http://dx.doi.org/10.1089/jmf.2011.0002] [PMID: 21861724]
[76]
Pothuraju R, Sharma RK, Chagalamarri J, Jangra S, Kumar Kavadi P. A systematic review of Gymnema sylvestre in obesity and diabetes management. J Sci Food Agric 2014; 94(5): 834-40.
[http://dx.doi.org/10.1002/jsfa.6458] [PMID: 24166097]
[77]
Kanetkar P, Singhal R, Kamat M. Recent advances in indian herbal drug research guest editor: thomas Paul Asir Devasagayam Gymnema sylvestre: A memoir.J Clinical Biochem Nutri 2007; 41(2): 77-81.
[78]
Porchezhian E, Dobriyal RM. An overview on the advances of Gymnema sylvestre: Chemistry, pharmacology and patents. ChemInform 2003; 34(19): 5-12.
[http://dx.doi.org/10.1002/chin.200319223] [PMID: 12622244]
[79]
Murakami N, Murakami T, Kadoya M, Matsuda H, Yamahara J, Yoshikawa M. New hypoglycemic constituents in “gymnemic acid” from Gymnema sylvestre. Chem Pharm Bull 1996; 44(2): 469-71.
[http://dx.doi.org/10.1248/cpb.44.469] [PMID: 8998848]
[80]
Bhandari U, Tripathi CD, Khanna G, Kumar V. Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model. Indian J Pharmacol 2012; 44(5): 607-13.
[http://dx.doi.org/10.4103/0253-7613.100387] [PMID: 23112423]
[81]
David BC, Sudarsanam G. Antimicrobial activity of Gymnema sylvestre (Asclepiadaceae). J Acute Dis 2013; 2(3): 222-5.
[http://dx.doi.org/10.1016/S2221-6189(13)60131-6]
[82]
Bishayee A, Chatterjee M. Hypolipidaemic and antiatherosclerotic effects of oral Gymnema sylvestre R. Br. Leaf extract in albino rats fed on a high fat diet. Phytother Res 1994; 8(2): 118-20.
[http://dx.doi.org/10.1002/ptr.2650080216]
[83]
Diwan PV, Margaret I, Ramakrishna S. Influence of Gymnema sylvestre on inflammation. Inflammopharmacology 1995; 3(3): 271-7.
[http://dx.doi.org/10.1007/BF02659124]
[84]
Srividya AR, Varma SK, Dhanapal SP, Vadivelan R, Vijayan P. In vitro and in vivo evaluation of hepatoprotective activity of Gymnema sylvestre. Int J Pharm Sci Nanotechnol 2010; 2(4): 768-73.
[85]
Gomes A, Das R, Sarkhel S, et al. Herbs and herbal constituents active against snake bite. Indian J Exp Biol 2010; 48(9): 865-78.
[PMID: 21506494]
[86]
Kiranmai M, Kazim SM, Ibrahim M. Combined wound healing activity of Gymnema sylvestre and Tagetes erecta linn. Int J Pharma Appli 2011; 2(2): 135-40.
[87]
Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: An important medicinal plant. BioMed Res Int 2014; 2014: 1-18.
[http://dx.doi.org/10.1155/2014/830285] [PMID: 24511547]
[88]
Kang MH, Lee MS, Choi MK, Min KS, Shibamoto T. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. J Agric Food Chem 2012; 60(10): 2517-24.
[http://dx.doi.org/10.1021/jf205086b] [PMID: 22360666]
[89]
Mall GK, Mishra PK, Prakash V. Antidiabetic and hypolipidemic activity of Gymnema sylvestre in alloxan induced diabetic rats. Global J Biotechnol Biochem 2009; 4(1): 37-42.
[90]
Ahmed AB, Rao AS, Rao MV. Role of in vivo leaf and in vitro callus of Gymnema sylvestre in maintaining the normal levels of blood glucose and lipid profile in diabetic Wistar rats. Biomed 2008; 28(2): 134-8.
[91]
Patel SS, Shah RS, Goyal RK. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp Biol 2009; 47(7): 564-70.
[PMID: 19761040]
[92]
Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed 2012; 2(4): 320-30.
[http://dx.doi.org/10.1016/S2221-1691(12)60032-X] [PMID: 23569923]
[93]
Sahu NP, Mahato SB, Sarkar SK, Poddar G. Triterpenoid saponins from Gymnema sylvestre. Phytochemistry 1996; 41(4): 1181-5.
[http://dx.doi.org/10.1016/0031-9422(95)00782-2] [PMID: 8728717]
[94]
Ota M, Shimizu Y, Tonosaki K, Ariyoshi Y. Role of hydrophobic amino acids in gurmarin, a sweetness-suppressing polypeptide. Biopolymers 1998; 45(3): 231-8.
[http://dx.doi.org/10.1002/(SICI)1097-0282(199803)45:3<231:AID-BIP5>3.0.CO;2-S] [PMID: 9465786]
[95]
Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadirachta Indica). Curr Sci 2002; 82(11): 1336-45.
[96]
Maithani A, Parcha V, Pant G, Dhulia I, Kumar D. Azadirachta Indica (neem) leaf: A review. J Pharm Res 2011; 4(6): 1824-7.
[97]
National Research Council.Neem: A Tree for Solving Global Problems. The National Academies Press 1992.
[98]
Talwar GP, Shah S, Mukherjee S, Chabra R. Induced termination of pregnancy by purified extracts of Azadirachta Indica (Neem): Mechanisms involved. Am J Reprod Immunol 1997; 37(6): 485-91.
[http://dx.doi.org/10.1111/j.1600-0897.1997.tb00264.x] [PMID: 9228306]
[99]
Khosla P, Sangeeta B, Singh J, Srivastava RK. Antinociceptive activity of Azadirachta Indica (neem) in rats. Indian J Pharmacol 2000; 32(6): 372-4.
[100]
Chagas ACS, Vieira LS, Freitas AR, et al. Anthelmintic efficacy of neem (Azadirachta Indica A. Juss) and the homeopathic product Fator Vermes® in Morada Nova sheep. Vet Parasitol 2008; 151(1): 68-73.
[http://dx.doi.org/10.1016/j.vetpar.2007.10.003] [PMID: 18022188]
[101]
Thakurta P, Bhowmik P, Mukherjee S, Hajra TK, Patra A, Bag PK. Antibacterial, antisecretory and antihemorrhagic activity of Azadirachta Indica used to treat cholera and diarrhea in India. J Ethnopharmacol 2007; 111(3): 607-12.
[http://dx.doi.org/10.1016/j.jep.2007.01.022] [PMID: 17314018]
[102]
Tiwari V, Darmani NA, Yue BYJT, Shukla D. In vitro antiviral activity of neem ( Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytother Res 2010; 24(8): 1132-40.
[http://dx.doi.org/10.1002/ptr.3085] [PMID: 20041417]
[103]
Mahmoud DA, Hassanein NM, Youssef KA, Abou Zeid MA. Antifungal activity of different neem leaf extracts and the nimonol against some important human pathogens. Braz J Microbiol 2011; 42(3): 1007-16.
[http://dx.doi.org/10.1590/S1517-83822011000300021] [PMID: 24031718]
[104]
Udeinya JI, Shu EN, Quakyi I, Ajayi FO. An antimalarial neem leaf extract has both schizonticidal and gametocytocidal activities. Am J Ther 2008; 15(2): 108-10.
[http://dx.doi.org/10.1097/MJT.0b013e31804c6d1d] [PMID: 18356629]
[105]
Mishra V, Parveen N, Singhal KC, Khan NU. Antifilarial activity of Azadirachta Indica on cattle filarial parasite Setaria cervi. Fitoterapia 2005; 76(1): 54-61.
[http://dx.doi.org/10.1016/j.fitote.2004.10.010] [PMID: 15664463]
[106]
Chattopadhyay I, Nandi B, Chatterjee R, Biswas K, Bandyopadhyay U, Banerjee RK. Mechanism of antiulcer effect of Neem (Azadirachta Indica) leaf extract: Effect on H+-K+-ATPase, oxidative damage and apoptosis. Inflammopharmacology 2004; 12(2): 153-76.
[http://dx.doi.org/10.1163/1568560041352257] [PMID: 15265317]
[107]
Okpanyi S, Ezeukwu G. Anti-inflammatory and antipyretic activities of Azadirachta Indica. Planta Med 1981; 41(1): 34-9.
[http://dx.doi.org/10.1055/s-2007-971670] [PMID: 6972048]
[108]
Ross IA. Medicinal plants of the world: Chemical constituents. Traditional and modern medicinal uses, Totowa. New Jersy 2001; 2: 81-5.
[109]
Kaushic C, Upadhyay S. Mode of long-term antifertility effect of intrauterine neem treatment (IUNT). Contraception 1995; 51(3): 203-7.
[http://dx.doi.org/10.1016/0010-7824(95)00018-6] [PMID: 7621690]
[110]
Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002; 81(1): 81-100.
[http://dx.doi.org/10.1016/S0378-8741(02)00059-4] [PMID: 12020931]
[111]
Brahmachari G. Neem--an omnipotent plant: A retrospection. ChemBioChem 2004; 5(4): 408-21.
[http://dx.doi.org/10.1002/cbic.200300749] [PMID: 15185362]
[112]
Nisbet AJ. Azadirachtin from the neem tree Azadirachta Indica: Its action against insects. An Soc Entomol Bras 2000; 29(4): 615-32.
[http://dx.doi.org/10.1590/S0301-80592000000400001]
[113]
Paul R, Prasad M, Sah NK. Anticancer biology of Azadirachta Indica L (neem): A mini review. Cancer Biol Ther 2011; 12(6): 467-76.
[http://dx.doi.org/10.4161/cbt.12.6.16850] [PMID: 21743298]
[114]
Dayakar A, Chandrasekaran S, Veronica J, Sundar S, Maurya R. In vitro and in vivo evaluation of anti-leishmanial and immunomodulatory activity of Neem leaf extract in Leishmania donovani infection. Exp Parasitol 2015; 153: 45-54.
[http://dx.doi.org/10.1016/j.exppara.2015.02.011] [PMID: 25747203]
[115]
Gupta S, Kataria M, Gupta PK, Murganandan S, Yashroy RC. Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. J Ethnopharmacol 2004; 90(2-3): 185-9.
[http://dx.doi.org/10.1016/j.jep.2003.09.024] [PMID: 15013179]
[116]
Satyanarayana MK, Narayana RD, Krishna RD, Gopalakrishna ML. A preliminary study on hypoglycaemic and antihyperglycaemic effects of Azadirachta Indica. Indian J Pharmacol 1978; 10(3): 247.
[117]
Khosla P, Bhanwra S, Singh J, Seth S, Srivastava RK. A study of hypoglycaemic effects of Azadirachta Indica (Neem) in normaland alloxan diabetic rabbits. Indian J Physiol Pharmacol 2000; 44(1): 69-74.
[PMID: 10919098]
[118]
Chattopadhyay RR. Possible mechanism of antihyperglycemic effect of Azadirachta Indica leaf extract: Part V. J Ethnopharmacol 1999; 67(3): 373-6.
[http://dx.doi.org/10.1016/S0378-8741(99)00094-X] [PMID: 10617075]
[119]
Ogunmodede OS, Saalu LC, Ogunlade B, Akunna GG, Oyewopo AO. An evaluation of the hypoglycemic, antioxidant and hepatoprotective potentials of onion (Allium cepa L.) on alloxan-induced diabetic rabbits. Int J Pharmacol 2011; 8(1): 21-9.
[http://dx.doi.org/10.3923/ijp.2012.21.29]
[120]
Bystrická J, Musilová J, Vollmannová A, Timoracká M, Kavalcová P. Bioactive components of onion ( Allium cepa L.) — a Review. Acta Aliment 2013; 42(1): 11-22.
[http://dx.doi.org/10.1556/AAlim.42.2013.1.2]
[121]
Ansari NA. Onion cultivation and production in Iran. Middle Eastern and Russian Journal of Plant Science and Biotechnology 2007; 1(2): 26-38.
[122]
Singh AK. Exotic ancient plant introductions: Part of Indian ‘Ayurveda’ medicinal system. Plant Genet Resour 2016; 14(4): 356-69.
[http://dx.doi.org/10.1017/S1479262116000368]
[123]
Teyssier C, Amiot MJ, Mondy N, Auger J, Kahane R, Siess MH. Effect of onion consumption by rats on hepatic drug-metabolizing enzymes. Food Chem Toxicol 2001; 39(10): 981-7.
[http://dx.doi.org/10.1016/S0278-6915(01)00056-4] [PMID: 11524136]
[124]
Campos KE, Diniz YS, Cataneo AC, Faine LA, Alves MJQF, Novelli ELB. Hypoglycaemic and antioxidant effects of onion, Allium cepa : Dietary onion addition, antioxidant activity and hypoglycaemic effects on diabetic rats. Int J Food Sci Nutr 2003; 54(3): 241-6.
[http://dx.doi.org/10.1080/09637480120092062] [PMID: 12775373]
[125]
Gabler NK, Ostrowska E, Jones RB, et al. Consumption of brown onion (Allium cepa) cultivars reduce the risk factors of cardiovascular disease. Proceedings of the Australian Post harvest Horticulture Conference. Brisbane, Australia. 2003; pp. 1-3.
[126]
Wang BS, Chen JH, Liang YC, Duh PD. Effects of Welsh onion on oxidation of low-density lipoprotein and nitric oxide production in macrophage cell line RAW 264.7. Food Chem 2005; 91(1): 147-55.
[http://dx.doi.org/10.1016/j.foodchem.2004.06.009]
[127]
Prakash D, Singh BN, Upadhyay G. Antioxidant and free radical scavenging activities of phenols from onion (Allium cepa). Food Chem 2007; 102(4): 1389-93.
[http://dx.doi.org/10.1016/j.foodchem.2006.06.063]
[128]
Benkeblia N. Antimicrobial activity of essential oil extracts of various onions (Allium cepa) and garlic (Allium sativum). Lebensm Wiss Technol 2004; 37(2): 263-8.
[http://dx.doi.org/10.1016/j.lwt.2003.09.001]
[129]
Goldman IL, Kopelberg M, Debaene JEP, Schwartz BS. Antiplatelet activity in onion (Allium cepa) is sulfur dependent. Thromb Haemost 1996; 76(3): 450-2.
[http://dx.doi.org/10.1055/s-0038-1650598] [PMID: 8883285]
[130]
Stavric B. Chemopreventive agents in foodsFunctionality of food phytochemicals. Boston, MA: Springer 1997; pp. 53-87.
[http://dx.doi.org/10.1007/978-1-4615-5919-1_3]
[131]
Park S, Kim MY, Lee DH, et al. Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect. Eur J Nutr 2009; 48(4): 235-42.
[http://dx.doi.org/10.1007/s00394-009-0007-0] [PMID: 19234663]
[132]
Ye CL, Dai DH, Hu WL. Antimicrobial and antioxidant activities of the essential oil from onion (Allium cepa L.). Food Control 2013; 30(1): 48-53.
[http://dx.doi.org/10.1016/j.foodcont.2012.07.033]
[133]
Kaiser P, Youssouf MS, Tasduq SA, et al. Anti-allergic effects of herbal product from Allium cepa (bulb). J Med Food 2009; 12(2): 374-82.
[http://dx.doi.org/10.1089/jmf.2007.0642] [PMID: 19459740]
[134]
Shams-Ghahfarokhi M, Shokoohamiri MR, Amirrajab N, et al. In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes. Fitoterapia 2006; 77(4): 321-3.
[http://dx.doi.org/10.1016/j.fitote.2006.03.014] [PMID: 16690223]
[135]
Kelkar SM, Kaklij GS, Bapat VA. Determination of antidiabetic activity in Allium cepa (onion) tissue cultures. Indian J Biochem Biophys 2001; 38(4): 277-9.
[PMID: 11811626]
[136]
Aboelhadid SM, Kamel AA, Arafa WM, Shokier KA. Effect of Allium sativum and Allium cepa oils on different stages of Boophilus annulatus. Parasitol Res 2013; 112(5): 1883-90.
[http://dx.doi.org/10.1007/s00436-013-3344-0] [PMID: 23435922]
[137]
Kumari K, Augusti KT. Antidiabetic and antioxidant effects of S-methyl cysteine sulfoxide isolated from onions (Allium cepa Linn) as compared to standard drugs in alloxan diabetic rats. Indian J Exp Biol 2002; 40(9): 1005-9.
[PMID: 12587728]
[138]
El-Demerdash FM, Yousef MI, El-Naga NIA. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol 2005; 43(1): 57-63.
[http://dx.doi.org/10.1016/j.fct.2004.08.012] [PMID: 15582196]
[139]
Kumari K, Mathew BC, Augusti KT. Antidiabetic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian J Biochem Biophys 1995; 32(1): 49-54.
[PMID: 7665195]
[140]
Marrelli M, Amodeo V, Statti G, Conforti F. Biological properties and bioactive components of Allium cepa L.: Focus on potential benefits in the treatment of obesity and related comorbidities. Molecules 2018; 24(1): 119.
[http://dx.doi.org/10.3390/molecules24010119] [PMID: 30598012]
[141]
Inoue M, Craker LE. Medicinal and aromatic plants—Uses and functions. InHorticulture. Plants for People and Places Springer Dordrecht 2014; 2: 645-69.
[142]
lawrence R, lawrence K. Antioxidant activity of garlic essential oil (Allium sativum) grown in north Indian plains. Asian Pac J Trop Biomed 2011; 1(1): S51-4.
[http://dx.doi.org/10.1016/S2221-1691(11)60122-6]
[143]
Uchida Y, Takahashi T, Sato N. [The characteristics of the antibacterial activity of garlic (author’s transl)] Jpn J Antibiot 1975; 28(4): 638-42.
[PMID: 1099271]
[144]
Harris JC, Plummer S, Turner MP, Lloyd D. The microaerophilic flagellate Giardia intestinalis: Allium sativum (garlic) is an effective antigiardial. Microbiology (Reading) 2000; 146(12): 3119-27.
[http://dx.doi.org/10.1099/00221287-146-12-3119] [PMID: 11101670]
[145]
Yoshida S, Kasuga S, Hayashi N, Ushiroguchi T, Matsuura H, Nakagawa S. Antifungal activity of ajoene derived from garlic. Appl Environ Microbiol 1987; 53(3): 615-7.
[http://dx.doi.org/10.1128/aem.53.3.615-617.1987] [PMID: 3555334]
[146]
Mehrbod P, Amini E, Tavassoti-Kheiri M. Antiviral activity of garlic extract on Influenza virus. Iran J Virol 2009; 3(1): 19-23.
[http://dx.doi.org/10.21859/isv.3.1.19]
[147]
Kaschula CH, Hunter R, Parker MI. Garlic-derived anticancer agents: Structure and biological activity of ajoene. Biofactors 2010; 36(1): NA.
[http://dx.doi.org/10.1002/biof.76] [PMID: 20108330]
[148]
Lee DY, Li H, Lim HJ, Lee HJ, Jeon R, Ryu JH. Anti-inflammatory activity of sulfur-containing compounds from garlic. J Med Food 2012; 15(11): 992-9.
[http://dx.doi.org/10.1089/jmf.2012.2275] [PMID: 23057778]
[149]
Thomson M, Al-Amin ZM, Al-Qattan KK, Shaban LH, Ali M. Anti-diabetic and hypolipidaemic properties of garlic (Allium sativum) in streptozotocin-induced diabetic rats. Int J Diabetes Metab 2007; 15: 108-15.
[150]
Chandrashekar PM, Prashanth KVH, Venkatesh YP. Isolation, structural elucidation and immunomodulatory activity of fructans from aged garlic extract. Phytochemistry 2011; 72(2-3): 255-64.
[http://dx.doi.org/10.1016/j.phytochem.2010.11.015] [PMID: 21168173]
[151]
Zahid Ashraf M, Hussain ME, Fahim M. Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats. Life Sci 2005; 77(8): 837-57.
[http://dx.doi.org/10.1016/j.lfs.2004.11.039] [PMID: 15964306]
[152]
Ariga T, Seki T. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: A review. Biofactors 2006; 26(2): 93-103.
[http://dx.doi.org/10.1002/biof.5520260201] [PMID: 16823096]
[153]
Sendl A. Allium sativum and Allium ursinum: Part 1 Chemistry, analysis, history, botany. Phytomedicine 1995; 1(4): 323-39.
[http://dx.doi.org/10.1016/S0944-7113(11)80011-5] [PMID: 23196023]
[154]
Divya BJ, Suman B, Venkataswamy M, Thyagaraju K. A study on phytochemicals, functional groups and mineral composition of Allium sativum (garlic) cloves. Int J Curr Pharm Res 2017; 9(3): 42-5.
[http://dx.doi.org/10.22159/ijcpr.2017.v9i3.18888]
[155]
Sumiyoshi H. New pharmacological activities of garlic and its constituents. Japanese Journal of Pharmacology 1997; 110(1): 93-7.
[156]
Mikaili P, Maadirad S, Moloudizargari M, Aghajanshakeri S, Sarahroodi S. Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds. Iran J Basic Med Sci 2013; 16(10): 1031-48.
[PMID: 24379960]
[157]
Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 2006; 13(9-10): 624-9.
[http://dx.doi.org/10.1016/j.phymed.2005.09.010] [PMID: 17085291]
[158]
Suleria H A, Butt M S, Anjum F M, et al. Aqueous garlic extract attenuates hypercholesterolemic and hyperglycemic perspectives; rabbit experimental modeling. J Med Plants Res 2017; 7(23): 1709.
[159]
Ghosh D, Mandal I, Rumi JF, et al. Effect of Allium sativum leaf extracts on glucose tolerance in glucose-induced hyperglycemic mice. Adv Nat Applied Sci 2014; 8(8): 66-70.
[160]
Augusti KT. Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). Indian J Exp Biol 1996; 34(7): 634-40.
[PMID: 8979497]
[161]
Makri O, Kintzios S. Ocimum sp.(basil): Botany, cultivation, pharmaceutical properties, and biotechnology. J Herbs Spices Med Plants 2008; 13(3): 123-50.
[http://dx.doi.org/10.1300/J044v13n03_10]
[162]
Baliga MS, Jimmy R, Thilakchand KR, et al. Ocimum sanctum L (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer. Nutr Cancer 2013; 65(sup1) (Suppl. 1): 26-35.
[http://dx.doi.org/10.1080/01635581.2013.785010] [PMID: 23682780]
[163]
Bhattacharyya P, Bishayee A. Ocimum sanctum Linn. (Tulsi): An ethnomedicinal plant for the prevention and treatment of cancer. Anticancer Drugs 2013; 24(7): 659-66.
[http://dx.doi.org/10.1097/CAD.0b013e328361aca1] [PMID: 23629478]
[164]
Khan A, Ahmad A, Akhtar F, et al. Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity. Res Microbiol 2010; 161(10): 816-23.
[http://dx.doi.org/10.1016/j.resmic.2010.09.008] [PMID: 20868749]
[165]
Magesh V, Lee JC, Ahn KS, et al. Ocimum sanctum induces apoptosis in A549 lung cancer cells and suppresses the in vivo growth of lewis lung carcinoma cells. Phytother Res 2009; 23(10): 1385-91.
[http://dx.doi.org/10.1002/ptr.2784] [PMID: 19277950]
[166]
Singh E, Sharma S, Dwivedi J, Sharma S. Diversified potentials of Ocimum sanctum Linn (Tulsi): An exhaustive survey. J Nat Prod Plant Resour 2012; 2(1): 39-48.
[167]
Pessoa LM, Morais SM, Bevilaqua CML, Luciano JHS. Anthelmintic activity of essential oil of Ocimum gratissimum Linn. and eugenol against Haemonchus contortus. Vet Parasitol 2002; 109(1-2): 59-63.
[http://dx.doi.org/10.1016/S0304-4017(02)00253-4] [PMID: 12383625]
[168]
Singh S, Majumdar DK. Analgesic activity of Ocimum sanctum and its possible mechanism of action. Int J Pharmacol 1995; 33(3): 188-92.
[169]
Singh S, Majumdar DK. Evaluation of antiinflammatory activity of fatty acids of Ocimum sanctum fixed oil. Indian J Exp Biol 1997; 35(4): 380-3.
[PMID: 9315239]
[170]
Vats V, Grover JK, Rathi SS. Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats. J Ethnopharmacol 2002; 79(1): 95-100.
[http://dx.doi.org/10.1016/S0378-8741(01)00374-9] [PMID: 11744301]
[171]
Ahmed M, Ahamed RN, Aladakatti RH, Ghosesawar MG. Reversible anti-fertility effect of benzene extract of Ocimum sanctum leaves on sperm parameters and fructose content in rats. J Basic Clin Physiol Pharmacol 2002; 13(1): 51-9.
[http://dx.doi.org/10.1515/JBCPP.2002.13.1.51] [PMID: 12099405]
[172]
Ravindran R, Devi RS, Samson J, Senthilvelan M. Noise-stress-induced brain neurotransmitter changes and the effect of Ocimum sanctum (Linn) treatment in albino rats. J Pharmacol Sci 2005; 98(4): 354-60.
[http://dx.doi.org/10.1254/jphs.FP0050127] [PMID: 16113498]
[173]
Singh S, Majumdar DK. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil). J Ethnopharmacol 1999; 65(1): 13-9.
[http://dx.doi.org/10.1016/S0378-8741(98)00142-1] [PMID: 10350365]
[174]
Lahon K, Das S. Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats. Pharmacognosy Res 2011; 3(1): 13-8.
[http://dx.doi.org/10.4103/0974-8490.79110] [PMID: 21731390]
[175]
Singh S, Rehan HMS, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001; 78(2-3): 139-43.
[http://dx.doi.org/10.1016/S0378-8741(01)00336-1] [PMID: 11694358]
[176]
Parasuraman S, Balamurugan S, Christapher P, et al. Evaluation of antidiabetic and antihyperlipidemic effects of hydroalcoholic extract of leaves of Ocimum tenuiflorum (Lamiaceae) and prediction of biological activity of its phytoconstituents. Pharmacognosy Res 2015; 7(2): 156-65.
[http://dx.doi.org/10.4103/0974-8490.151457] [PMID: 25829789]
[177]
Kelm MA, Nair MG, Strasburg GM, DeWitt DL. Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine 2000; 7(1): 7-13.
[http://dx.doi.org/10.1016/S0944-7113(00)80015-X] [PMID: 10782484]
[178]
Pattanayak P, Behera P, Das D, Panda S. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacogn Rev 2010; 4(7): 95-105.
[http://dx.doi.org/10.4103/0973-7847.65323] [PMID: 22228948]
[179]
Rahman S, Islam R, Kamruzzaman M, Alam K, Jamal AH. Ocimum sanctum L: A review of phytochemical and pharmacological profile. Am J Drug Discov Develop 2011; pp. 1-5.
[180]
Gupta SK, Prakash J, Srivastava S. Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J Exp Biol 2002; 40(7): 765-73.
[PMID: 12597545]
[181]
Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. Radiation protection by the ocimum flavonoids orientin and vicenin: Mechanisms of action. Radiat Res 2000; 154(4): 455-60.
[http://dx.doi.org/10.1667/0033-7587(2000)154[0455:RPBTOF]2.0.CO;2] [PMID: 11023610]
[182]
Singh D, Chaudhuri PK. A review on phytochemical and pharmacological properties of Holy basil (Ocimum sanctum L.). Ind Crops Prod 2018; 118: 367-82.
[http://dx.doi.org/10.1016/j.indcrop.2018.03.048]
[183]
Sethi J, Sood S, Seth S, Talwar A. Evaluation of hypoglycemic and antioxidant effect of Ocimum sanctum. Indian J Clin Biochem 2004; 19(2): 152-5.
[http://dx.doi.org/10.1007/BF02894276] [PMID: 23105475]
[184]
Suanarunsawat T, Anantasomboon G, Piewbang C. Anti-diabetic and anti-oxidative activity of fixed oil extracted from Ocimum sanctum L. leaves in diabetic rats. Exp Ther Med 2016; 11(3): 832-40.
[http://dx.doi.org/10.3892/etm.2016.2991] [PMID: 26998000]
[185]
Arenal A, Martín L, Castillo NM, de la Torre D, Torres U, González R. Aqueous extract of Ocimum tenuiflorum decreases levels of blood glucose in induced hyperglycemic tilapia (Oreochromis niloticus). Asian Pac J Trop Med 2012; 5(8): 634-7.
[http://dx.doi.org/10.1016/S1995-7645(12)60130-8] [PMID: 22840452]
[186]
Hannan JMA, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YHA. Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic β-cells. J Endocrinol 2006; 189(1): 127-36.
[http://dx.doi.org/10.1677/joe.1.06615] [PMID: 16614387]
[187]
Sánchez-Machado DI, López-Cervantes J, Sendón R, Sanches-Silva A. Aloe vera : Ancient knowledge with new frontiers. Trends Food Sci Technol 2017; 61: 94-102.
[http://dx.doi.org/10.1016/j.tifs.2016.12.005]
[188]
Eshun K, He Q. Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries--a review. Crit Rev Food Sci Nutr 2004; 44(2): 91-6.
[http://dx.doi.org/10.1080/10408690490424694] [PMID: 15116756]
[189]
Grindlay D, Reynolds T. The Aloe vera phenomenon: A review of the properties and modern uses of the leaf parenchyma gel. J Ethnopharmacol 1986; 16(2-3): 117-51.
[http://dx.doi.org/10.1016/0378-8741(86)90085-1] [PMID: 3528673]
[190]
Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian J Dermatol 2008; 53(4): 163-6.
[http://dx.doi.org/10.4103/0019-5154.44785] [PMID: 19882025]
[191]
Choi S-W, Son B-W, Son Y-S, Park Y-I, Lee S-K, Chung M-H. The wound-healing effect of a glycoprotein fraction isolated from aloe vera. Br J Dermatol 2001; 145(4): 535-45.
[http://dx.doi.org/10.1046/j.1365-2133.2001.04410.x] [PMID: 11703278]
[192]
Vijayalakshmi D, Dhandapani R, Jayaveni S, Jithendra PS, Rose C, Mandal AB. In vitro anti inflammatory activity of Aloe vera by down regulation of MMP-9 in peripheral blood mononuclear cells. J Ethnopharmacol 2012; 141(1): 542-6.
[http://dx.doi.org/10.1016/j.jep.2012.02.040] [PMID: 22446321]
[193]
Wahedi HM, Jeong M, Chae JK, Do SG, Yoon H, Kim SY. Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine 2017; 28: 19-26.
[http://dx.doi.org/10.1016/j.phymed.2017.02.005] [PMID: 28478809]
[194]
Zhang X, Wang H, Song Y, et al. Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera. Bioorg Med Chem Lett 2006; 16(4): 949-53.
[http://dx.doi.org/10.1016/j.bmcl.2005.10.096] [PMID: 16297615]
[195]
Ashafa AT, Abass AA, Sunmonu TO, Ogbe AA. Laxative potential of the ethanolic leaf extract of Aloe vera (L.) Burm. f. in Wistar rats with loperamide-induced constipation. Journal of Natural Pharmaceuticals 2011; 2(3): 158-62.
[http://dx.doi.org/10.4103/2229-5119.86268]
[196]
Pecere T, Gazzola MV, Mucignat C, et al. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res 2000; 60(11): 2800-4.
[PMID: 10850417]
[197]
Agyare C, Spiegler V, Sarkodie H, Asase A, Liebau E, Hensel A. An ethnopharmacological survey and in vitro confirmation of the ethnopharmacological use of medicinal plants as anthelmintic remedies in the Ashanti region, in the central part of Ghana. J Ethnopharmacol 2014; 158(A): 255-63.
[198]
Saleem AM, Gopal V, Rafiullah MRM, Bharathidasan P. Chemical and pharmacological evaluation of Karpura shilajit bhasma, an ayurvedic diuretic formulation. Afr J Tradit Complement Altern Med 2006; 3(2): 27-36.
[http://dx.doi.org/10.4314/ajtcam.v3i2.31154]
[199]
Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 1996; 3(3): 245-8.
[http://dx.doi.org/10.1016/S0944-7113(96)80061-4] [PMID: 23195078]
[200]
Fani M, Kohanteb J. Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria. J Oral Sci 2012; 54(1): 15-21.
[http://dx.doi.org/10.2334/josnusd.54.15] [PMID: 22466882]
[201]
Hu Q, Hu Y, Xu J. Free radical-scavenging activity of Aloe vera (Aloe barbadensis Miller) extracts by supercritical carbon dioxide extraction. Food Chem 2005; 91(1): 85-90.
[http://dx.doi.org/10.1016/j.foodchem.2004.05.052]
[202]
Rosca-Casian O, Parvu M, Vlase L, Tamas M. Antifungal activity of Aloe vera leaves. Fitoterapia 2007; 78(3): 219-22.
[http://dx.doi.org/10.1016/j.fitote.2006.11.008] [PMID: 17336466]
[203]
Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R. Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis. Phytother Res 2012; 26(4): 617-9.
[http://dx.doi.org/10.1002/ptr.3589] [PMID: 21915932]
[204]
Zandi K, Zadeh MA, Sartavi K, Rastian Z. Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study. Afr J Biotechnol 2007; 6(15)
[205]
Sahu PK, Giri DD, Singh R, et al. Therapeutic and medicinal uses of Aloe vera: A review. Pharmacol Pharm 2013; 4(8): 599-610.
[http://dx.doi.org/10.4236/pp.2013.48086]
[206]
Reynolds T. The compounds in Aloë leaf exudates: A review. Bot J Linn Soc 1985; 90(3): 157-77.
[http://dx.doi.org/10.1111/j.1095-8339.1985.tb00377.x]
[207]
Joseph B, Raj SJ. Pharmacognostic and phytochemical properties of Aloe vera linn an overview. Int J Pharm Sci Rev Res 2010; 4(2): 106-10.
[208]
Gupta V, Malhotra S. Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies. Ayu 2012; 33(2): 193-6.
[http://dx.doi.org/10.4103/0974-8520.105237] [PMID: 23559789]
[209]
Huseini H, Kianbakht S, Hajiaghaee R, Dabaghian F. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. Planta Med 2012; 78(4): 311-6.
[http://dx.doi.org/10.1055/s-0031-1280474] [PMID: 22198821]
[210]
Mohamed EA. Antidiabetic, antihypercholestermic and antioxidative effect of Aloe vera gel extract in alloxan induced diabetic rats. Aust J Basic Appl Sci 2011; 5(11): 1321-7.
[211]
Noor A, Gunasekaran S, Manickam AS, Vijayalakshmi MA. Antidiabetic activity of Aloe vera and histology of organs in streptozotocin-induced diabetic rats. Curr Sci 2008; 94(8): 1070-6.
[212]
Ghosh B, Chandra I, Chatterjee S. Fenugreek (Trigonella foenum-graecum L.) and its necessity. Fire J Engin Technol 2015; 1(1): 66-7.
[213]
Nagulapalli Venkata KC, Swaroop A, Bagchi D, Bishayee A. A small plant with big benefits: Fenugreek ( Trigonella foenum-graecum Linn.) for disease prevention and health promotion. Mol Nutr Food Res 2017; 61(6): 1600950.
[http://dx.doi.org/10.1002/mnfr.201600950] [PMID: 28266134]
[214]
Bahmani M, Shirzad H, Mirhosseini M, Mesripour A, Rafieian-Kopaei M. A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). J Evid Based Complementary Altern Medicine 2016; 21(1): 53-62.
[215]
Petropoulos GA. Fenugreek: The genus Trigonella. CRC Press 2003.
[216]
Madhava Naidu M, Shyamala BN, Pura Naik J, Sulochanamma G, Srinivas P. Chemical composition and antioxidant activity of the husk and endosperm of fenugreek seeds. Lebensm Wiss Technol 2011; 44(2): 451-6.
[http://dx.doi.org/10.1016/j.lwt.2010.08.013]
[217]
Hibasami H, Moteki H, Ishikawa K, et al. Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III. Int J Mol Med 2003; 11(1): 23-6.
[http://dx.doi.org/10.3892/ijmm.11.1.23] [PMID: 12469212]
[218]
Sharma MS, Choudhary PR. Hypolipidemic effect of fenugreek seeds and its comparison with atorvastatin on experimentally induced hyperlipidemia. J Coll Physicians Surg Pak 2014; 24(8): 539-42.
[PMID: 25149829]
[219]
Sharififar F, Khazaeli P, Alli N. In vivo evaluation of anti-inflammatory activity of topical preparations from Fenugreek (Trigonella foenum-graecum L.) seeds in a cream base. Iranian J Pharma Sci 2009; 5(3): 157-62.
[220]
Sindhu G, Ratheesh M, Shyni GL, Nambisan B, Helen A. Anti-inflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (Fenugreek) on adjuvant induced arthritic rats. Int Immunopharmacol 2012; 12(1): 205-11.
[http://dx.doi.org/10.1016/j.intimp.2011.11.012] [PMID: 22155102]
[221]
Kumar GS, Shetty AK, Sambaiah K, Salimath PV. Antidiabetic property of fenugreek seed mucilage and spent turmeric in streptozotocin-induced diabetic rats. Nutr Res 2005; 25(11): 1021-8.
[http://dx.doi.org/10.1016/j.nutres.2005.09.012]
[222]
Sulieman AM, Ahmed HE, Abdelrahim AM. The Chemical Composition of Fenugreek (Trigonella foenum graceum L) and the Antimicrobial properties of its Seed Oil. J Eng Appl Sci (Asian Res Publ Netw) 2008; 3(2): 52-71.
[223]
Al-Habori M, Raman A. Antidiabetic and hypocholesterolaemic effects of fenugreek. Phytother Res 1998; 12(4): 233-42.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199806)12:4<233:AID-PTR294>3.0.CO;2-V]
[224]
Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S. Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Immunopharmacol 2003; 3(2): 257-65.
[http://dx.doi.org/10.1016/S1567-5769(02)00292-8] [PMID: 12586606]
[225]
hamden K, Masmoudi H, Carreau S, elfeki A. Immunomodulatory, β-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes. Immunopharmacol Immunotoxicol 2010; 32(3): 437-45.
[http://dx.doi.org/10.3109/08923970903490486] [PMID: 20100065]
[226]
Eidi A, Eidi M, Sokhteh M. Effect of fenugreek (Trigonella foenum-graecum L) seeds on serum parameters in normal and streptozotocin-induced diabetic rats. Nutr Res 2007; 27(11): 728-33.
[http://dx.doi.org/10.1016/j.nutres.2007.09.006]
[227]
Devi BA, Kamalakkannan N, Prince PSM. Supplementation of fenugreek leaves to diabetic rats. Effect on carbohydrate metabolic enzymes in diabetic liver and kidney. Phytother Res 2003; 17(10): 1231-3.
[http://dx.doi.org/10.1002/ptr.1357] [PMID: 14669264]
[228]
Kumar P, Kale RK, Mukherjee S, Prakash K, McLean P, Baquer NZ. Antidiabetic effects of Trigonella foenum-graecum seed powder in a rat model. Toxicol Environ Chem 2011; 93(10): 2085-97.
[http://dx.doi.org/10.1080/02772248.2011.626418]
[229]
Sauvaire Y, Petit P, Broca C, et al. 4-Hydroxyisoleucine: A novel amino acid potentiator of insulin secretion. Diabetes 1998; 47(2): 206-10.
[http://dx.doi.org/10.2337/diab.47.2.206] [PMID: 9519714]
[230]
Kirtikar KR, Basu BD. Indian Medicinal Plants. In: International Book Distributer. 1918; pp. 1038-63.
[231]
Beloin N, Gbeassor M, Akpagana K, et al. Ethnomedicinal uses of Momordica charantia (Cucurbitaceae) in Togo and relation to its phytochemistry and biological activity. J Ethnopharmacol 2005; 96(1-2): 49-55.
[http://dx.doi.org/10.1016/j.jep.2004.08.009] [PMID: 15588650]
[232]
Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: A review. J Ethnopharmacol 2004; 93(1): 123-32.
[http://dx.doi.org/10.1016/j.jep.2004.03.035] [PMID: 15182917]
[233]
Ng TB, Chan WY, Yeung HW. Proteins with abortifacient, ribosome inactivating, immunomodulatory, antitumor and anti-AIDS activities from Cucurbitaceae plants. Gen Pharmacol 1992; 23(4): 575-90.
[http://dx.doi.org/10.1016/0306-3623(92)90131-3] [PMID: 1397965]
[234]
Scartezzini P, Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol 2000; 71(1-2): 23-43.
[http://dx.doi.org/10.1016/S0378-8741(00)00213-0] [PMID: 10904144]
[235]
Zafar R, Neerja. Momordica charantia--a review. Hamdard Med 1991; 34(3): 49-61.
[PMID: 11613982]
[236]
Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis 2013; 3(2): 93-102.
[http://dx.doi.org/10.1016/S2222-1808(13)60052-3]
[237]
Miura T, Itoh C, Iwamoto N, et al. Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice. J Nutr Sci Vitaminol 2001; 47(5): 340-4.
[http://dx.doi.org/10.3177/jnsv.47.340] [PMID: 11814149]
[238]
Virdi J, Sivakami S, Shahani S, Suthar AC, Banavalikar MM, Biyani MK. Antihyperglycemic effects of three extracts from Momordica charantia. J Ethnopharmacol 2003; 88(1): 107-11.
[http://dx.doi.org/10.1016/S0378-8741(03)00184-3] [PMID: 12902059]
[239]
Fernandes NPC, Lagishetty CV, Panda VS, Naik SR. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern Med 2007; 7(1): 29.
[http://dx.doi.org/10.1186/1472-6882-7-29] [PMID: 17892543]

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