Title:Catalytic Behavior of Histidine-bearing Self-assembling Peptide for Ester
Hydrolysis
Volume: 20
Issue: 10
Author(s): Yanfei Liu*, Lei Huang, Peili Feng, Luoying Chen, Huanhuan He and Hui Chen
Affiliation:
- Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi, China
Keywords:
Self-assembling peptide, artificial enzyme, nanofiber, β-sheet structure, hydrophobic interaction, catalytic hydrogel.
Abstract: Artificial enzyme mimics have lately sparked a lot of attention since they offer a lot of benefits
over natural enzymes. Because of their proteic origin and tailorable structures, self-assembling
peptides are ideal building blocks for the creation of artificial enzymes. Recently, a series of histidinebearing
self-assembling peptides with β-sheet structures, which are selective for short-chain fatty acids,
were described. In this work, the catalytic behaviors of these peptides were further investigated
using 2,4-dinitrophenyl acetate (DNPA) as a model substrate. Furthermore, the peptide was capable of
forming a solid hydrogel that was also catalytically active at higher concentrations.
