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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Perspective

Dyslipidemia and Cardiovascular Prevention in the Elderly: A Balance between Benefits and Risks of Statin Treatment in a Specific Population

Author(s): Vincenzo Fiore, Alessandra Barucca, Sonia Barraco, Domenico Triggiani, Daniele Tragni, Giuseppina Piazzolla, Vincenzo Triggiani, Giovanni Carbotta* and Giuseppe Lisco*

Volume 23, Issue 11, 2023

Published on: 09 June, 2023

Page: [1371 - 1379] Pages: 9

DOI: 10.2174/1871530323666230428092828

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Abstract

Introduction: Atherosclerotic Cardiovascular Diseases (CVD) are among the most relevant causes of morbidity and mortality worldwide, especially in aged people. Statins are one of the leading pharmacological interventions against atherosclerosis and are widely used to reduce the risk of occurring coronary artery diseases and related outcomes in both primary and secondary prevention. The management of chronic diseases is improved considerably over time, leading to an increase in life expectancy despite heavier comorbidity-related burdens in the elderly.

Aims: The paper focused on the role of statins in the management of atherosclerosis and related burdens in elderly patients.

Results: Statins are essential in reducing the risk of CVD in secondary and primary prevention, particularly in high-risk individuals. Guidelines encourage using specific algorithms with age-specific cutoffs to assess individual cardiovascular risk irrespective of baseline age, as the expansion of life expectancy produces favorable effects of statin treatment in those over 70.

Discussion: Besides the estimation of baseline CV risk, a specific age-related assessment is also necessary before prescribing statin treatment in aged people focusing on frailty, potential pharmacological interactions due to polypharmacotherapy, cognitive impairment, and background chronic comorbidities, such as diabetes mellitus. Before starting statin therapy, an accurate choice of type and dose of statins is needed as potential adverse events are more prevalent with high-dose than low-to-moderatedose regimens and with lipophile than hydrophile statins (e.g., potential implication on intra-cerebral cholesterol metabolism).

Conclusion: Despite possible adverse events, elderly patients should receive statins, when appropriate, to avoid the first occurrence of recurrent cardiovascular events and related burdens.

Keywords: Elderly, dyslipidemia, cardiovascular diseases, primary prevention, secondary prevention, frailty, cognition.

[1]
Horodinschi, R.N.; Stanescu, A.M.A.; Bratu, O.G.; Pantea. S., A.; Radavoi, D.G.; Diaconu, C.C. Treatment with statins in elderly patients. Medicina, 2019, 55(11), 721.
[http://dx.doi.org/10.3390/medicina55110721] [PMID: 31671689]
[2]
Robinson, J.G.; Bakris, G.; Torner, J.; Stone, N.J.; Wallace, R. Is it time for a cardiovascular primary prevention trial in the elderly? Stroke, 2007, 38(2), 441-450.
[http://dx.doi.org/10.1161/01.STR.0000254602.58896.d2] [PMID: 17194877]
[3]
Cybulski, M.; Krajewska-Kułak, E.; Sowa, P.; Orzechowska, M.; Van Damme-Ostapowicz, K.; Rozwadowska, E.; Guzowski, A. Elderly peoples’ perception of young people - A preliminary study. Iran. J. Public Health, 2013, 42(10), 1099-1105.
[PMID: 26060617]
[4]
Awad, K.; Mohammed, M.; Zaki, M.M.; Abushouk, A.I.; Lip, G.Y.H.; Blaha, M.J.; Lavie, C.J.; Toth, P.P.; Jukema, J.W.; Sattar, N.; Banach, M. Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: A systematic review and meta-analysis of observational studies. BMC Med., 2021, 19(1), 139.
[http://dx.doi.org/10.1186/s12916-021-02009-1] [PMID: 34154589]
[5]
Benjamin, E.J.; Blaha, M.J.; Chiuve, S.E.; Cushman, M.; Das, S.R.; Deo, R.; de Ferranti, S.D.; Floyd, J.; Fornage, M.; Gillespie, C.; Isasi, C.R.; Jiménez, M.C.; Jordan, L.C.; Judd, S.E.; Lackland, D.; Lichtman, J.H.; Lisabeth, L.; Liu, S.; Longenecker, C.T.; Mackey, R.H.; Matsushita, K.; Mozaffarian, D.; Mussolino, M.E.; Nasir, K.; Neumar, R.W.; Palaniappan, L.; Pandey, D.K.; Thiagarajan, R.R.; Reeves, M.J.; Ritchey, M.; Rodriguez, C.J.; Roth, G.A.; Rosamond, W.D.; Sasson, C.; Towfighi, A.; Tsao, C.W.; Turner, M.B.; Virani, S.S.; Voeks, J.H.; Willey, J.Z.; Wilkins, J.T.; Wu, J.H.Y.; Alger, H.M.; Wong, S.S.; Muntner, P. Heart disease and stroke statistics—2017 update: A report from the American Heart Association. Circulation, 2017, 135(10), e146-e603.
[http://dx.doi.org/10.1161/CIR.0000000000000485] [PMID: 28122885]
[6]
Mach, F.; Baigent, C.; Catapano, A.L.; Koskinas, K.C.; Casula, M.; Badimon, L.; Chapman, M.J.; De Backer, G.G.; Delgado, V.; Ference, B.A.; Graham, I.M.; Halliday, A.; Landmesser, U.; Mihaylova, B.; Pedersen, T.R.; Riccardi, G.; Richter, D.J.; Sabatine, M.S.; Taskinen, M.R.; Tokgozoglu, L.; Wiklund, O.; Mueller, C.; Drexel, H.; Aboyans, V.; Corsini, A.; Doehner, W.; Farnier, M.; Gigante, B.; Kayikcioglu, M.; Krstacic, G.; Lambrinou, E.; Lewis, B.S.; Masip, J.; Moulin, P.; Petersen, S.; Petronio, A.S.; Piepoli, M.F.; Pintó, X.; Räber, L.; Ray, K.K.; Reiner, Ž.; Riesen, W.F.; Roffi, M.; Schmid, J-P.; Shlyakhto, E.; Simpson, I.A.; Stroes, E.; Sudano, I.; Tselepis, A.D.; Viigimaa, M.; Vindis, C.; Vonbank, A.; Vrablik, M.; Vrsalovic, M.; Zamorano, J.L.; Collet, J-P.; Koskinas, K.C.; Casula, M.; Badimon, L.; John Chapman, M.; De Backer, G.G.; Delgado, V.; Ference, B.A.; Graham, I.M.; Halliday, A.; Landmesser, U.; Mihaylova, B.; Pedersen, T.R.; Riccardi, G.; Richter, D.J.; Sabatine, M.S.; Taskinen, M-R.; Tokgozoglu, L.; Wiklund, O.; Windecker, S.; Aboyans, V.; Baigent, C.; Collet, J-P.; Dean, V.; Delgado, V.; Fitzsimons, D.; Gale, C.P.; Grobbee, D.; Halvorsen, S.; Hindricks, G.; Iung, B.; Jüni, P.; Katus, H.A.; Landmesser, U.; Leclercq, C.; Lettino, M.; Lewis, B.S.; Merkely, B.; Mueller, C.; Petersen, S.; Petronio, A.S.; Richter, D.J.; Roffi, M.; Shlyakhto, E.; Simpson, I.A.; Sousa-Uva, M.; Touyz, R.M.; Nibouche, D.; Zelveian, P.H.; Siostrzonek, P.; Najafov, R.; van de Borne, P.; Pojskic, B.; Postadzhiyan, A.; Kypris, L.; Špinar, J.; Larsen, M.L.; Eldin, H.S.; Viigimaa, M.; Strandberg, T.E.; Ferrières, J.; Agladze, R.; Laufs, U.; Rallidis, L.; Bajnok, L.; Gudjónsson, T.; Maher, V.; Henkin, Y.; Gulizia, M.M.; Mussagaliyeva, A.; Bajraktari, G.; Kerimkulova, A.; Latkovskis, G.; Hamoui, O.; Slapikas, R.; Visser, L.; Dingli, P.; Ivanov, V.; Boskovic, A.; Nazzi, M.; Visseren, F.; Mitevska, I.; Retterstøl, K.; Jankowski, P.; Fontes-Carvalho, R.; Gaita, D.; Ezhov, M.; Foscoli, M.; Giga, V.; Pella, D.; Fras, Z.; de Isla, L.P.; Hagström, E.; Lehmann, R.; Abid, L.; Ozdogan, O.; Mitchenko, O.; Patel, R.S. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk. Eur. Heart J., 2020, 41(1), 111-188.
[http://dx.doi.org/10.1093/eurheartj/ehz455] [PMID: 31504418]
[7]
Ferrucci, L.; Giallauria, F.; Guralnik, J.M. Epidemiology of aging. Radiol. Clin. North Am., 2008, 46(4), 643-652.
[http://dx.doi.org/10.1016/j.rcl.2008.07.005] [PMID: 18922285]
[8]
Dicker, D.; Nguyen, G.; Abate, D.; Abate, K.H.; Abay, S.M.; Abbafati, C.; Abbasi, N.; Abbastabar, H.; Abd-Allah, F.; Abdela, J.; Abdelalim, A.; Abdel-Rahman, O.; Abdi, A.; Abdollahpour, I.; Abdulkader, R.S.; Abdurahman, A.A.; Abebe, H.T.; Abebe, M.; Abebe, Z.; Abebo, T.A.; Aboyans, V.; Abraha, H.N.; Abrham, A.R.; Abu-Raddad, L.J.; Abu-Rmeileh, N.M.E.; Accrombessi, M.M.K.; Acharya, P.; Adebayo, O.M.; Adedeji, I.A.; Adedoyin, R.A.; Adekanmbi, V.; Adetokunboh, O.O.; Adhena, B.M.; Adhikari, T.B.; Adib, M.G.; Adou, A.K.; Adsuar, J.C.; Afarideh, M.; Afshin, A.; Agarwal, G.; Aggarwal, R.; Aghayan, S.A.; Agrawal, S.; Agrawal, A.; Ahmadi, M.; Ahmadi, A.; Ahmadieh, H.; Ahmed, M.L.C.; Ahmed, S.; Ahmed, M.B.; Aichour, A.N.; Aichour, I.; Aichour, M.T.E.; Akanda, A.S.; Akbari, M.E.; Akibu, M.; Akinyemi, R.O.; Akinyemiju, T.; Akseer, N.; Alahdab, F.; Al-Aly, Z.; Alam, K.; Alebel, A.; Aleman, A.V.; Alene, K.A.; Al-Eyadhy, A.; Ali, R.; Alijanzadeh, M.; Alizadeh-Navaei, R.; Aljunid, S.M.; Alkerwi, A.; Alla, F.; Allebeck, P.; Allen, C.A.; Alonso, J.; Al-Raddadi, R.M.; Alsharif, U.; Altirkawi, K.; Alvis-Guzman, N.; Amare, A.T.; Amini, E.; Ammar, W.; Amoako, Y.A.; Anber, N.H.; Andrei, C.L.; Androudi, S.; Animut, M.D.; Anjomshoa, M.; Anlay, D.Z.; Ansari, H.; Ansariadi, A.; Ansha, M.G.; Antonio, C.A.T.; Appiah, S.C.Y.; Aremu, O.; Areri, H.A.; Ärnlöv, J.; Arora, M.; Artaman, A.; Aryal, K.K.; Asadi-Lari, M.; Asayesh, H.; Asfaw, E.T.; Asgedom, S.W.; Assadi, R.; Ataro, Z.; Atey, T.M.M.; Athari, S.S.; Atique, S.; Atre, S.R.; Atteraya, M.S.; Attia, E.F.; Ausloos, M.; Avila-Burgos, L.; Avokpaho, E.F.G.A.; Awasthi, A.; Awuah, B.; Ayala Quintanilla, B.P.; Ayele, H.T.; Ayele, Y.; Ayer, R.; Ayuk, T.B.; Azzopardi, P.S.; Azzopardi-Muscat, N.; Badali, H.; Badawi, A.; Balakrishnan, K.; Bali, A.G.; Banach, M.; Banstola, A.; Barac, A.; Barboza, M.A.; Barquera, S.; Barrero, L.H.; Basaleem, H.; Bassat, Q.; Basu, A.; Basu, S.; Baune, B.T.; Bazargan-Hejazi, S.; Bedi, N.; Beghi, E.; Behzadifar, M.; Behzadifar, M.; Béjot, Y.; Bekele, B.B.; Belachew, A.B.; Belay, A.G.; Belay, E.; Belay, S.A.; Belay, Y.A.; Bell, M.L.; Bello, A.K.; Bennett, D.A.; Bensenor, I.M.; Berhane, A.; Berman, A.E.; Bernabe, E.; Bernstein, R.S.; Bertolacci, G.J.; Beuran, M.; Beyranvand, T.; Bhala, N.; Bhatia, E.; Bhatt, S.; Bhattarai, S.; Bhaumik, S.; Bhutta, Z.A.; Biadgo, B.; Bijani, A.; Bikbov, B.; Bililign, N.; Bin Sayeed, M.S.; Birlik, S.M.; Birungi, C.; Bisanzio, D.; Biswas, T.; Bjørge, T.; Bleyer, A.; Basara, B.B.; Bose, D.; Bosetti, C.; Boufous, S.; Bourne, R.; Brady, O.J.; Bragazzi, N.L.; Brant, L.C.; Brazinova, A.; Breitborde, N.J.K.; Brenner, H.; Britton, G.; Brugha, T.; Burke, K.E.; Busse, R.; Butt, Z.A.; Cahuana-Hurtado, L.; Callender, C.S.K.H.; Campos-Nonato, I.R.; Campuzano Rincon, J.C.; Cano, J.; Car, M.; Cárdenas, R.; Carreras, G.; Carrero, J.J.; Carter, A.; Carvalho, F.; Castañeda-Orjuela, C.A.; Castillo Rivas, J.; Castro, F.; Catalá-López, F.; Çavlin, A.; Cerin, E.; Chaiah, Y.; Champs, A.P.; Chang, HY.; Chang, J-C.; Chattopadhyay, A.; Chaturvedi, P.; Chen, W.; Chiang, P.P-C.; Chimed-Ochir, O.; Chin, K.L.; Chisumpa, V.H.; Chitheer, A.; Choi, J-Y.J.; Christensen, H.; Christopher, D.J.; Chung, S-C.; Cicuttini, F.M.; Ciobanu, L.G.; Cirillo, M.; Claro, R.M.; Cohen, A.J.; Collado-Mateo, D.; Constantin, M-M.; Conti, S.; Cooper, C.; Cooper, L.T.; Cortesi, P.A.; Cortinovis, M.; Cousin, E.; Criqui, M.H.; Cromwell, E.A.; Crowe, C.S.; Crump, J.A.; Cucu, A.; Cunningham, M.; Daba, A.K.; Dachew, B.A.; Dadi, A.F.; Dandona, L.; Dandona, R.; Dang, A.K.; Dargan, P.I.; Daryani, A.; Das, S.K.; Das Gupta, R.; das Neves, J.; Dasa, T.T.; Dash, A.P.; Weaver, N.D.; Davitoiu, D.V.; Davletov, K.; Dayama, A.; Courten, B.; De la Hoz, F.P.; De leo, D.; De Neve, J-W.; Degefa, M.G.; Degenhardt, L.; Degfie, T.T.; Deiparine, S.; Dellavalle, R.P.; Demoz, G.T.; Demtsu, B.B.; Denova-Gutiérrez, E.; Deribe, K.; Dervenis, N.; Des Jarlais, D.C.; Dessie, G.A.; Dey, S.; Dharmaratne, S.D.; Dhimal, M.; Ding, E.L.; Djalalinia, S.; Doku, D.T.; Dolan, K.A.; Donnelly, C.A.; Dorsey, E.R.; Douwes-Schultz, D.; Doyle, K.E.; Drake, T.M.; Driscoll, T.R.; Dubey, M.; Dubljanin, E.; Duken, E.E.; Duncan, B.B.; Duraes, A.R.; Ebrahimi, H.; Ebrahimpour, S.; Edessa, D.; Edvardsson, D.; Eggen, A.E.; El Bcheraoui, C.; El Sayed Zaki, M.; Elfaramawi, M.; El-Khatib, Z.; Ellingsen, C.L.; Elyazar, I.R.F.; Enayati, A.; Endries, A.Y.Y.; Er, B.; Ermakov, S.P.; Eshrati, B.; Eskandarieh, S.; Esmaeili, R.; Esteghamati, A.; Esteghamati, S.; Fakhar, M.; Fakhim, H.; Farag, T.; Faramarzi, M.; Fareed, M.; Farhadi, F.; Farid, T.A.; Farinha, C.S.S.; Farioli, A.; Faro, A.; Farvid, M.S.; Farzadfar, F.; Farzaei, M.H.; Fazeli, M.S.; Feigin, V.L.; Feigl, A.B.; Feizy, F.; Fentahun, N.; Fereshtehnejad, S-M.; Fernandes, E.; Fernandes, J.C.; Feyissa, G.T.; Fijabi, D.O.; Filip, I.; Finegold, S.; Fischer, F.; Flor, L.S.; Foigt, N.A.; Ford, J.A.; Foreman, K.J.; Fornari, C.; Frank, T.D.; Franklin, R.C.; Fukumoto, T.; Fuller, J.E.; Fullman, N.; Fürst, T.; Furtado, J.M.; Futran, N.D.; Galan, A.; Gallus, S.; Gambashidze, K.; Gamkrelidze, A.; Gankpe, F.G.; Garcia-Basteiro, A.L.; Garcia-Gordillo, M.A.; Gebre, T.; Gebre, A.K.; Gebregergs, G.B.; Gebrehiwot, T.T.; Gebremedhin, A.T.; Gelano, T.F.; Gelaw, Y.A.; Geleijnse, J.M.; Genova-Maleras, R.; Gessner, B.D.; Getachew, S.; Gething, P.W.; Gezae, K.E.; Ghadami, M.R.; Ghadimi, R.; Ghasemi Falavarjani, K.; Ghasemi-Kasman, M.; Ghiasvand, H.; Ghimire, M.; Ghoshal, A.G.; Gill, P.S.; Gill, T.K.; Gillum, R.F.; Giussani, G.; Goenka, S.; Goli, S.; Gomez, R.S.; Gomez-Cabrera, M.C.; Gómez-Dantés, H.; Gona, P.N.; Goodridge, A.; Gopalani, S.V.; Goto, A.; Goulart, A.C.; Goulart, B.N.G.; Grada, A.; Grosso, G.; Gugnani, H.C.; Guimaraes, A.L.S.; Guo, Y.; Gupta, P.C.; Gupta, R.; Gupta, R.; Gupta, T.; Gyawali, B.; Haagsma, J.A.; Hachinski, V.; Hafezi-Nejad, N.; Hagos, T.B.; Hailegiyorgis, T.T.; Hailu, G.B.; Haj-Mirzaian, A.; Haj-Mirzaian, A.; Hamadeh, R.R.; Hamidi, S.; Handal, A.J.; Hankey, G.J.; Harb, H.L.; Harikrishnan, S.; Haririan, H.; Haro, J.M.; Hasan, M.; Hassankhani, H.; Hassen, H.Y.; Havmoeller, R.; Hay, R.J.; Hay, S.I.; He, Y.; Hedayatizadeh-Omran, A.; Hegazy, M.I.; Heibati, B.; Heidari, M.; Hendrie, D.; Henok, A.; Henry, N.J.; Heredia-Pi, I.; Herteliu, C.; Heydarpour, F.; Heydarpour, P.; Heydarpour, S.; Hibstu, D.T.; Hoek, H.W.; Hole, M.K.; Homaie Rad, E.; Hoogar, P.; Horino, M.; Hosgood, H.D.; Hosseini, S.M.; Hosseinzadeh, M.; Hostiuc, S.; Hostiuc, M.; Hotez, P.J.; Hoy, D.G.; Hsairi, M.; Htet, A.S.; Hu, G.; Huang, J.J.; Husseini, A.; Hussen, M.M.; Hutfless, S.; Iburg, K.M.; Igumbor, E.U.; Ikeda, C.T.; Ilesanmi, O.S.; Iqbal, U.; Irvani, S.S.N.; Isehunwa, O.O.; Islam, S.M.S.; Islami, F.; Jahangiry, L.; Jahanmehr, N.; Jain, R.; Jain, S.K.; Jakovljevic, M.; James, S.L.; Javanbakht, M.; Jayaraman, S.; Jayatilleke, A.U.; Jee, S.H.; Jeemon, P.; Jha, R.P.; Jha, V.; Ji, J.S.; Johnson, S.C.; Jonas, J.B.; Joshi, A.; Jozwiak, J.J.; Jungari, S.B.; Jürisson, M.; K, M.; Kabir, Z.; Kadel, R.; Kahsay, A.; Kahssay, M.; Kalani, R.; Kapil, U.; Karami, M.; Karami M., B.; Karch, A.; Karema, C.; Karimi, N.; Karimi, S.M.; Karimi-Sari, H.; Kasaeian, A.; Kassa, G.M.; Kassa, T.D.; Kassa, Z.Y.; Kassebaum, N.J.; Katibeh, M.; Katikireddi, S.V.; Kaul, A.; Kawakami, N.; Kazemeini, H.; Kazemi, Z.; Karyani, A.K.; K C, P.; Kebede, S.; Keiyoro, P.N.; Kemp, G.R.; Kengne, A.P.; Keren, A.; Kereselidze, M.; Khader, Y.S.; Khafaie, M.A.; Khajavi, A.; Khalid, N.; Khalil, I.A.; Khan, E.A.; Khan, G.; Khan, M.S.; Khan, M.A.; Khang, Y-H.; Khanna, T.; Khater, M.M.; Khatony, A.; Khazaie, H.; Khoja, A.T.; Khosravi, A.; Khosravi, M.H.; Khubchandani, J.; Kiadaliri, A.A.; Kibret, G.D.D.; Kim, C.; Kim, D.; Kim, J.Y.; Kim, Y-E.; Kimokoti, R.W.; Kinfu, Y.; Kinra, S.; Kisa, A.; Kissimova-Skarbek, K.; Kissoon, N.; Kivimäki, M.; Kleber, M.E.; Knibbs, L.D.; Knudsen, A.K.S.; Kochhar, S.; Kokubo, Y.; Kolola, T.; Kopec, J.A.; Kosek, M.N.; Kosen, S.; Koul, P.A.; Koyanagi, A.; Kravchenko, M.A.; Krishan, K.; Krishnaswami, S.; Kuate Defo, B.; Kucuk Bicer, B.; Kudom, A.A.; Kuipers, E.J.; Kulikoff, X.R.; Kumar, G.A.; Kumar, M.; Kumar, P.; Kumsa, F.A.; Kutz, M.J.; Lad, S.D.; Lafranconi, A.; Lal, D.K.; Lalloo, R.; Lam, H.; Lami, F.H.; Lan, Q.; Langan, S.M.; Lansingh, V.C.; Lansky, S.; Larson, H.J.; Laryea, D.O.; Lassi, Z.S.; Latifi, A.; Lavados, P.M.; Laxmaiah, A.; Lazarus, J.V.; Lebedev, G.; Lee, P.H.; Leigh, J.; Leshargie, C.T.; Leta, S.; Levi, M.; Li, S.; Li, Y.; Li, X.; Liang, J.; Liang, X.; Liben, M.L.; Lim, L-L.; Lim, S.S.; Limenih, M.A.; Linn, S.; Liu, S.; Liu, Y.; Lodha, R.; Logroscino, G.; Lonsdale, C.; Lorch, S.A.; Lorkowski, S.; Lotufo, P.A.; Lozano, R.; Lucas, T.C.D.; Lunevicius, R.; Lyons, R.A.; Ma, S.; Mabika, C.; Macarayan, E.R.K.; Mackay, M.T.; Maddison, E.R.; Maddison, R.; Madotto, F.; Magdy Abd El Razek, H.; Magdy Abd El Razek, M.; Maghavani, D.P.; Majdan, M.; Majdzadeh, R.; Majeed, A.; Malekzadeh, R.; Malik, M.A.; Malta, D.C.; Mamun, A.A.; Manamo, W.A.; Manda, A-L.; Mansournia, M.A.; Mantovani, L.G.; Mapoma, C.C.; Marami, D.; Maravilla, J.C.; Marcenes, W.; Marina, S.; Martinez-Raga, J.; Martins, S.C.O.; Martins-Melo, F.R.; März, W.; Marzan, M.B.; Mashamba-Thompson, T.P.; Masiye, F.; Massenburg, B.B.; Maulik, P.K.; Mazidi, M.; McGrath, J.J.; McKee, M.; Mehata, S.; Mehendale, S.M.; Mehndiratta, M.M.; Mehrotra, R.; Mehta, K.M.; Mehta, V.; Mekonen, T.; Mekonnen, T.C.; Meles, H.G.; Meles, K.G.; Melese, A.; Melku, M.; Memiah, P.T.N.; Memish, Z.A.; Mendoza, W.; Mengistu, D.T.; Mengistu, G.; Mensah, G.A.; Mereta, S.T.; Meretoja, A.; Meretoja, T.J.; Mestrovic, T.; Mezgebe, H.B.; Miangotar, Y.; Miazgowski, B.; Miazgowski, T.; Miller, T.R.; Mini, G.K.; Mirica, A.; Mirrakhimov, E.M.; Misganaw, A.T.; Moazen, B.; Moges, N.A.; Mohammad, K.A.; Mohammadi, M.; Mohammadifard, N.; Mohammadi-Khanaposhtani, M.; Mohammadnia-Afrouzi, M.; Mohammed, S.; Mohammed, M.A.; Mohan, V.; Mokdad, A.H.; Molokhia, M.; Monasta, L.; Moradi, G.; Moradi, M.; Moradi-Lakeh, M.; Moradinazar, M.; Moraga, P.; Morawska, L.; Moreno Velásquez, I.; Morgado-da-Costa, J.; Morrison, S.D.; Mosapour, A.; Moschos, M.M.; Mousavi, S.M.; Muche, A.A.; Muchie, K.F.; Mueller, U.O.; Mukhopadhyay, S.; Mullany, E.C.; Muller, K.; Murhekar, M.; Murphy, T.B.; Murthy, G.V.S.; Murthy, S.; Musa, J.; Musa, K.I.; Mustafa, G.; Muthupandian, S.; Nachega, J.B.; Nagel, G.; Naghavi, M.; Naheed, A.; Nahvijou, A.; Naik, G.; Nair, S.; Najafi, F.; Nangia, V.; Nansseu, J.R.; Nascimento, B.R.; Nawaz, H.; Ncama, B.P.; Neamati, N.; Negoi, I.; Negoi, R.I.; Neupane, S.; Newton, C.R.J.; Ngalesoni, F.N.; Ngunjiri, J.W.; Nguyen, H.T.; Nguyen, H.T.; Nguyen, L.H.; Nguyen, M.; Nguyen, T.H.; Ningrum, D.N.A.; Nirayo, Y.L.; Nisar, M.I.; Nixon, M.R.; Nolutshungu, N.; Nomura, S.; Norheim, O.F.; Noroozi, M.; Norrving, B.; Noubiap, J.J.; Nouri, H.R.; Nourollahpour Shiadeh, M.; Nowroozi, M.R.; Nsoesie, E.O.; Nyasulu, P.S.; Ofori-Asenso, R.; Ogah, O.S.; Ogbo, F.A.; Oh, I-H.; Okoro, A.; Oladimeji, O.; Olagunju, A.T.; Olagunju, T.O.; Olivares, P.R.; Olusanya, B.O.; Olusanya, J.O.; Ong, S.K.; Opio, J.N.; Oren, E.; Ortiz, J.R.; Ortiz, A.; Ota, E.; Otstavnov, S.S.; Øverland, S.; Owolabi, M.O.; Oyekale, A.S.; P A, M.; Pacella, R.; Pakhale, S.; Pakhare, A.P.; Pana, A.; Panda, B.K.; Panda-Jonas, S.; Pandey, A.R.; Pandian, J.D.; Parisi, A.; Park, E-K.; Parry, C.D.H.; Parsian, H.; Patel, S.; Patle, A.; Patten, S.B.; Patton, G.C.; Paudel, D.; Pearce, N.; Peprah, E.K.; Pereira, A.; Pereira, D.M.; Perez, K.M.; Perico, N.; Pervaiz, A.; Pesudovs, K.; Petri, W.A.; Petzold, M.; Phillips, M.R.; Pigott, D.M.; Pillay, J.D.; Pirsaheb, M.; Pishgar, F.; Plass, D.; Polinder, S.; Pond, C.D.; Popova, S.; Postma, M.J.; Pourmalek, F.; Pourshams, A.; Poustchi, H.; Prabhakaran, D.; Prakash, V.; Prakash, S.; Prasad, N.; Qorbani, M.; Quistberg, D.A.; Radfar, A.; Rafay, A.; Rafiei, A.; Rahim, F.; Rahimi, K.; Rahimi-Movaghar, A.; Rahimi-Movaghar, V.; Rahman, M.; Rahman, M.H.U.; Rahman, M.A.; Rahman, S.; Rai, R.K.; Rajati, F.; Rajsic, S.; Raju, S.B.; Ram, U.; Ranabhat, C.L.; Ranjan, P.; Ranta, A.; Rasella, D.; Rawaf, D.L.; Rawaf, S.; Ray, S.E.; Razo-García, C.; Rego, M.A.S.; Rehm, J.; Reiner, R.C.; Reinig, N.; Reis, C.; Remuzzi, G.; Renzaho, A.M.N.; Resnikoff, S.; Rezaei, S.; Rezaeian, S.; Rezai, M.S.; Riahi, S.M.; Ribeiro, A.L.P.; Riojas, H.; Rios-Blancas, M.J.; Roba, K.T.; Robinson, S.R.; Roever, L.; Ronfani, L.; Roshandel, G.; Roshchin, D.O.; Rostami, A.; Rothenbacher, D.; Rubagotti, E.; Ruhago, G.M.; Saadat, S.; Sabde, Y.D.; Sachdev, P.S.; Saddik, B.; Sadeghi, E.; Moghaddam, S.S.; Safari, H.; Safari, Y.; Safari-Faramani, R.; Safdarian, M.; Safi, S.; Safiri, S.; Sagar, R.; Sahebkar, A.; Sahraian, M.A.; Sajadi, H.S.; Salahshoor, M.R.; Salam, N.; Salama, J.S.; Salamati, P.; Saldanha, R.F.; Salimi, Y.; Salimzadeh, H.; Salz, I.; Sambala, E.Z.; Samy, A.M.; Sanabria, J.; Sanchez-Niño, M.D.; Santos, I.S.; Santos, J.V.; Santric Milicevic, M.M.; Sao Jose, B.P.; Sardana, M.; Sarker, A.R.; Sarrafzadegan, N.; Sartorius, B.; Sarvi, S.; Sathian, B.; Satpathy, M.; Savic, M.; Sawant, A.R.; Sawhney, M.; Saxena, S.; Sayyah, M.; Scaria, V.; Schaeffner, E.; Schelonka, K.; Schmidt, M.I.; Schneider, I.J.C.; Schöttker, B.; Schutte, A.E.; Schwebel, D.C.; Schwendicke, F.; Scott, J.G.; Sekerija, M.; Sepanlou, S.G.; Serván-Mori, E.; Shabaninejad, H.; Shackelford, K.A.; Shafieesabet, A.; Shaheen, A.A.; Shaikh, M.A.; Shakir, R.A.; Shams-Beyranvand, M.; Shamsi, M.B.; Shamsizadeh, M.; Sharafi, H.; Sharafi, K.; Sharif, M.; Sharif-Alhoseini, M.; Sharma, M.; Sharma, J.; Sharma, R.; She, J.; Sheikh, A.; Sheth, K.N.; Shi, P.; Shibuya, K.; Shifa, G.T.; Shiferaw, M.S.; Shigematsu, M.; Shiri, R.; Shirkoohi, R.; Shiue, I.; Shokraneh, F.; Shrime, M.G.; Shukla, S.R.; Si, S.; Siabani, S.; Siddiqi, T.J.; Sigfusdottir, I.D.; Sigurvinsdottir, R.; Silpakit, N.; Silva, D.A.S.; Silva, J.P.; Silveira, D.G.A.; Singam, N.S.V.; Singh, J.A.; Singh, V.; Sinha, A.P.; Sinha, D.N.; Sitas, F.; Skirbekk, V.; Sliwa, K.; Soares Filho, A.M.; Sobaih, B.H.; Sobhani, S.; Soofi, M.; Soriano, J.B.; Soyiri, I.N.; Sposato, L.A.; Sreeramareddy, C.T.; Srinivasan, V.; Srivastava, R.K.; Starodubov, V.I.; Stathopoulou, V.; Steel, N.; Stein, D.J.; Steiner, C.; Stewart, L.G.; Stokes, M.A.; Sudaryanto, A.; Sufiyan, M.B.; Sulo, G.; Sunguya, B.F.; Sur, P.J.; Sutradhar, I.; Sykes, B.L.; Sylaja, P.N.; Sylte, D.O.; Szoeke, C.E.I.; Tabarés-Seisdedos, R.; Tabuchi, T.; Tadakamadla, S.K.; Takahashi, K.; Tandon, N.; Tassew, A.A.; Tassew, S.G.; Tavakkoli, M.; Taveira, N.; Tawye, N.Y.; Tehrani-Banihashemi, A.; Tekalign, T.G.; Tekle, M.G.; Temesgen, H.; Temsah, M-H.; Temsah, O.; Terkawi, A.S.; Teshale, M.Y.; Tessema, B.; Teweldemedhin, M.; Thakur, J.S.; Thankappan, K.R.; Thirunavukkarasu, S.; Thomas, L.A.; Thomas, N.; Thrift, A.G.; Tilahun, B.; To, Q.G.; Tobe-Gai, R.; Tonelli, M.; Topor-Madry, R.; Topouzis, F.; Torre, A.E.; Tortajada-Girbés, M.; Tovani-Palone, M.R.; Towbin, J.A.; Tran, B.X.; Tran, K.B.; Tripathi, S.; Tripathy, S.P.; Truelsen, T.C.; Truong, N.T.; Tsadik, A.G.; Tsilimparis, N.; Tudor Car, L.; Tuzcu, E.M.; Tyrovolas, S.; Ukwaja, K.N.; Ullah, I.; Usman, M.S.; Uthman, O.A.; Uzun, S.B.; Vaduganathan, M.; Vaezi, A.; Vaidya, G.; Valdez, P.R.; Varavikova, E.; Varughese, S.; Vasankari, T.J.; Vasconcelos, A.M.N.; Venketasubramanian, N.; Vidavalur, R.; Villafaina, S.; Violante, F.S.; Vladimirov, S.K.; Vlassov, V.; Vollset, S.E.; Vos, T.; Vosoughi, K.; Vujcic, I.S.; Wagner, G.R.; Wagnew, F.W.S.; Waheed, Y.; Wang, Y.; Wang, Y-P.; Wassie, M.M.; Weiderpass, E.; Weintraub, R.G.; Weiss, D.J.; Weiss, J.; Weldegebreal, F.; Weldegwergs, K.G.; Werdecker, A.; Westerman, R.; Whiteford, H.A.; Widecka, J.; Widecka, K.; Wijeratne, T.; Winkler, A.S.; Wiysonge, C.S.; Wolfe, C.D.A.; Wondemagegn, S.A.; Wu, S.; Wyper, G.M.A.; Xu, G.; Yadav, R.; Yakob, B.; Yamada, T.; Yan, L.L.; Yano, Y.; Yaseri, M.; Yasin, Y.J.; Ye, P.; Yearwood, J.A.; Yentür, G.K.; Yeshaneh, A.; Yimer, E.M.; Yip, P.; Yisma, E.; Yonemoto, N.; Yoon, SJ.; York, H.W.; Yotebieng, M.; Younis, M.Z.; Yousefifard, M.; Yu, C.; Zachariah, G.; Zadnik, V.; Zafar, S.; Zaidi, Z.; Zaman, S.B.; Zamani, M.; Zare, Z.; Zeeb, H.; Zeleke, M.M.; Zenebe, Z.M.; Zerfu, T.A.; Zhang, K.; Zhang, X.; Zhou, M.; Zhu, J.; Zodpey, S.; Zucker, I.; Zuhlke, L.J.J.; Lopez, A.D.; Gakidou, E.; Murray, C.J.L. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159), 1684-1735.
[http://dx.doi.org/10.1016/S0140-6736(18)31891-9] [PMID: 30496102]
[9]
Hughes, S. Statin benefits in the elderly: New meta-analysis. Medscape, 2019.
[10]
Visseren, F.L.J.; Mach, F.; Smulders, Y.M.; Carballo, D.; Koskinas, K.C.; Bäck, M.; Benetos, A.; Biffi, A.; Boavida, J.M.; Capodanno, D.; Cosyns, B.; Crawford, C.; Davos, C.H.; Desormais, I.; Di Angelantonio, E.; Franco, O.H.; Halvorsen, S.; Hobbs, F.D.R.; Hollander, M.; Jankowska, E.A.; Michal, M.; Sacco, S.; Sattar, N.; Tokgozoglu, L.; Tonstad, S.; Tsioufis, K.P.; van Dis, I.; van Gelder, I.C.; Wanner, C.; Williams, B.; De Backer, G.; Regitz-Zagrosek, V.; Aamodt, A.H.; Abdelhamid, M.; Aboyans, V.; Albus, C.; Asteggiano, R.; Bäck, M.; Borger, M.A.; Brotons, C.; Čelutkienė, J.; Cifkova, R.; Cikes, M.; Cosentino, F.; Dagres, N.; De Backer, T.; De Bacquer, D.; Delgado, V.; Den Ruijter, H.; Dendale, P.; Drexel, H.; Falk, V.; Fauchier, L.; Ference, B.A.; Ferrières, J.; Ferrini, M.; Fisher, M.; Fliser, D.; Fras, Z.; Gaita, D.; Giampaoli, S.; Gielen, S.; Graham, I.; Jennings, C.; Jorgensen, T.; Kautzky-Willer, A.; Kavousi, M.; Koenig, W.; Konradi, A.; Kotecha, D.; Landmesser, U.; Lettino, M.; Lewis, B.S.; Linhart, A.; Løchen, M-L.; Makrilakis, K.; Mancia, G.; Marques-Vidal, P.; McEvoy, J.W.; McGreavy, P.; Merkely, B.; Neubeck, L.; Nielsen, J.C.; Perk, J.; Petersen, S.E.; Petronio, A.S.; Piepoli, M.; Pogosova, N.G.; Prescott, E.I.B.; Ray, K.K.; Reiner, Z.; Richter, D.J.; Rydén, L.; Shlyakhto, E.; Sitges, M.; Sousa-Uva, M.; Sudano, I.; Tiberi, M.; Touyz, R.M.; Ungar, A.; Verschuren, W.M.M.; Wiklund, O.; Wood, D.; Zamorano, J.L.; Smulders, Y.M.; Carballo, D.; Koskinas, K.C.; Bäck, M.; Benetos, A.; Biffi, A.; Boavida, J-M.; Capodanno, D.; Cosyns, B.; Crawford, C.A.; Davos, C.H.; Desormais, I.; Di Angelantonio, E.; Franco Duran, O.H.; Halvorsen, S.; Richard, H., F.D.; Hollander, M.; Jankowska, E.A.; Michal, M.; Sacco, S.; Sattar, N.; Tokgozoglu, L.; Tonstad, S.; Tsioufis, K.P.; Dis, I.; van Gelder, I.C.; Wanner, C.; Williams, B. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur. Heart J., 2021, 42(34), 3227-3337.
[http://dx.doi.org/10.1093/eurheartj/ehab484] [PMID: 34458905]
[11]
Stoll, F.; Eidam, A.; Bauer, J.M.; Haefeli, W.E. Management of dyslipidaemia in the elderly. J. Cardiol. Pract., 2020, 19(5)
[12]
Singh, S.; Zieman, S.; Go, A.S.; Fortmann, S.P.; Wenger, N.K.; Fleg, J.L.; Radziszewska, B.; Stone, N.J.; Zoungas, S.; Gurwitz, J.H. Statins for primary prevention in older adults-moving toward evidence-based decision-making. J. Am. Geriatr. Soc., 2018, 66(11), 2188-2196.
[http://dx.doi.org/10.1111/jgs.15449] [PMID: 30277567]
[13]
Wilmot, K.A.; Khan, A.; Krishnan, S.; Eapen, D.J.; Sperling, L. Statins in the elderly: A patient-focused approach. Clin. Cardiol., 2015, 38(1), 56-61.
[http://dx.doi.org/10.1002/clc.22338] [PMID: 25336290]
[14]
Shepherd, J.; Blauw, G.J.; Murphy, M.B.; Bollen, E.L.E.M.; Buckley, B.M.; Cobbe, S.M.; Ford, I.; Gaw, A.; Hyland, M.; Jukema, J.W.; Kamper, A.M.; Macfarlane, P.W.; Meinders, A.E.; Norrie, J.; Packard, C.J.; Perry, I.J.; Stott, D.J.; Sweeney, B.J.; Twomey, G.; Westendorp, R.G.J. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial. Lancet, 2002, 360(9346), 1623-1630.
[http://dx.doi.org/10.1016/S0140-6736(02)11600-X] [PMID: 12457784]
[15]
Han, B.H.; Sutin, D.; Williamson, J.D.; Davis, B.R.; Piller, L.B.; Pervin, H.; Pressel, S.L.; Blaum, C.S. Effect of statin treatment vs usual care on primary cardiovascular prevention among older adults. JAMA Intern. Med., 2017, 177(7), 955-965.
[http://dx.doi.org/10.1001/jamainternmed.2017.1442] [PMID: 28531241]
[16]
Ridker, P.M.; Danielson, E.; Fonseca, F.A.H.; Genest, J.; Gotto, A.M., Jr; Kastelein, J.J.P.; Koenig, W.; Libby, P.; Lorenzatti, A.J.; MacFadyen, J.G.; Nordestgaard, B.G.; Shepherd, J.; Willerson, J.T.; Glynn, R.J. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med., 2008, 359(21), 2195-2207.
[http://dx.doi.org/10.1056/NEJMoa0807646] [PMID: 18997196]
[17]
Yusuf, S.; Bosch, J.; Dagenais, G.; Zhu, J.; Xavier, D.; Liu, L.; Pais, P.; López-Jaramillo, P.; Leiter, L.A.; Dans, A.; Avezum, A.; Piegas, L.S.; Parkhomenko, A.; Keltai, K.; Keltai, M.; Sliwa, K.; Peters, R.J.G.; Held, C.; Chazova, I.; Yusoff, K.; Lewis, B.S.; Jansky, P.; Khunti, K.; Toff, W.D.; Reid, C.M.; Varigos, J.; Sanchez-Vallejo, G.; McKelvie, R.; Pogue, J.; Jung, H.; Gao, P.; Diaz, R.; Lonn, E. Cholesterol lowering in intermediate-risk persons without cardiovascular disease. N. Engl. J. Med., 2016, 374(21), 2021-2031.
[http://dx.doi.org/10.1056/NEJMoa1600176] [PMID: 27040132]
[18]
Ridker, P.M.; Lonn, E.; Paynter, N.P.; Glynn, R.; Yusuf, S. Primary prevention with statin therapy in the elderly. Circulation, 2017, 135(20), 1979-1981.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028271] [PMID: 28385949]
[19]
Mangione, C.M.; Barry, M.J.; Nicholson, W.K.; Cabana, M.; Chelmow, D.; Coker, T.R.; Davis, E.M.; Donahue, K.E.; Jaén, C.R.; Kubik, M.; Li, L.; Ogedegbe, G.; Pbert, L.; Ruiz, J.M.; Stevermer, J.; Wong, J.B. Statin use for the primary prevention of cardiovascular disease in adults. JAMA, 2022, 328(8), 746-753.
[http://dx.doi.org/10.1001/jama.2022.13044] [PMID: 35997723]
[20]
Efficacy and safety of statin therapy in older people: A meta-analysis of individual participant data from 28 randomised controlled trials. Lancet, 2019, 393(10170), 407-415.
[http://dx.doi.org/10.1016/S0140-6736(18)31942-1] [PMID: 30712900]
[21]
Deedwania, P.; Stone, P.H.; Bairey Merz, C.N.; Cosin-Aguilar, J.; Koylan, N.; Luo, D.; Ouyang, P.; Piotrowicz, R.; Schenck-Gustafsson, K.; Sellier, P.; Stein, J.H.; Thompson, P.L.; Tzivoni, D. Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: Results of the Study Assessing Goals in the Elderly (SAGE). Circulation, 2007, 115(6), 700-707.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.106.654756] [PMID: 17283260]
[22]
Amarenco, P.; Bogousslavsky, J.; Callahan, A., III; Goldstein, L.B.; Hennerici, M.; Rudolph, A.E.; Sillesen, H.; Simunovic, L.; Szarek, M.; Welch, K.M.; Zivin, J.A. High-dose atorvastatin after stroke or transient ischemic attack. N. Engl. J. Med., 2006, 355(6), 549-559.
[http://dx.doi.org/10.1056/NEJMoa061894] [PMID: 16899775]
[23]
Lee, M.; Cheng, C.Y.; Wu, Y.L.; Lee, J.D.; Hsu, C.Y.; Ovbiagele, B. Association between intensity of low-density lipoprotein cholesterol reduction with statin-based therapies and secondary stroke prevention. JAMA Neurol., 2022, 79(4), 349-358.
[http://dx.doi.org/10.1001/jamaneurol.2021.5578] [PMID: 35188949]
[24]
Morley, J.E.; Vellas, B.; Abellan van Kan, G.; Anker, S.D.; Bauer, J.M.; Bernabei, R.; Cesari, M.; Chumlea, W.C.; Doehner, W.; Evans, J.; Fried, L.P.; Guralnik, J.M.; Katz, P.R.; Malmstrom, T.K.; McCarter, R.J.; Gutierrez Robledo, L.M.; Rockwood, K.; von Haehling, S.; Vandewoude, M.F.; Walston, J. Frailty consensus: A call to action. J. Am. Med. Dir. Assoc., 2013, 14(6), 392-397.
[http://dx.doi.org/10.1016/j.jamda.2013.03.022] [PMID: 23764209]
[25]
Newman, C.B.; Preiss, D.; Tobert, J.A.; Jacobson, T.A.; Page, R.L., II; Goldstein, L.B.; Chin, C.; Tannock, L.R.; Miller, M.; Raghuveer, G.; Duell, P.B.; Brinton, E.A.; Pollak, A.; Braun, L.T.; Welty, F.K. Statin safety and associated adverse events: A scientific statement from the American Heart Association. Arterioscler. Thromb. Vasc. Biol., 2019, 39(2), e38-e81.
[http://dx.doi.org/10.1161/ATV.0000000000000073] [PMID: 30580575]
[26]
Hong, S.; Li, Q.C.; Jun, X. Treatment of dyslipidemia in the elderly. J. Geriatr. Cardiol., 2011, 8(1), 55-64.
[http://dx.doi.org/10.3724/SP.J.1263.2011.00055] [PMID: 22783285]
[27]
Link, E.; Parish, S.; Armitage, J.; Bowman, L.; Heath, S.; Matsuda, F.; Gut, I.; Lathrop, M.; Collins, R. SLCO1B1 variants and statin-induced myopathy - A genomewide study. N. Engl. J. Med., 2008, 359(8), 789-799.
[http://dx.doi.org/10.1056/NEJMoa0801936] [PMID: 18650507]
[28]
Schech, S.; Graham, D.; Staffa, J.; Andrade, S.E.; Grenade, L.L.; Burgess, M.; Blough, D.; Stergachis, A.; Chan, K.A.; Platt, R.; Shatin, D. Risk factors for statin-associated rhabdomyolysis. Pharmacoepidemiol. Drug Saf., 2007, 16(3), 352-358.
[http://dx.doi.org/10.1002/pds.1287] [PMID: 16892458]
[29]
Sattar, N.; Preiss, D.; Murray, H.M.; Welsh, P.; Buckley, B.M.; de Craen, A.J.M.; Seshasai, S.R.K.; McMurray, J.J.; Freeman, D.J.; Jukema, J.W.; Macfarlane, P.W.; Packard, C.J.; Stott, D.J.; Westendorp, R.G.; Shepherd, J.; Davis, B.R.; Pressel, S.L.; Marchioli, R.; Marfisi, R.M.; Maggioni, A.P.; Tavazzi, L.; Tognoni, G.; Kjekshus, J.; Pedersen, T.R.; Cook, T.J.; Gotto, A.M.; Clearfield, M.B.; Downs, J.R.; Nakamura, H.; Ohashi, Y.; Mizuno, K.; Ray, K.K.; Ford, I. Statins and risk of incident diabetes: A collaborative meta-analysis of randomised statin trials. Lancet, 2010, 375(9716), 735-742.
[http://dx.doi.org/10.1016/S0140-6736(09)61965-6] [PMID: 20167359]
[30]
Simsek, S.; Schalkwijk, C.G.; Wolffenbuttel, B.H.R. Effects of rosuvastatin and atorvastatin on glycaemic control in Type 2 diabetes-the CORALL study. Diabet. Med., 2012, 29(5), 628-631.
[http://dx.doi.org/10.1111/j.1464-5491.2011.03553.x] [PMID: 22151023]
[31]
Lloyd-Jones, D.M.; Leip, E.P.; Larson, M.G.; D’Agostino, R.B.; Beiser, A.; Wilson, P.W.F.; Wolf, P.A.; Levy, D. Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation, 2006, 113(6), 791-798.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.105.548206] [PMID: 16461820]
[32]
Kearney, P.M.; Blackwell, L.; Collins, R.; Keech, A.; Simes, J.; Peto, R.; Armitage, J.; Baigent, C. Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: A meta-analysis. Lancet, 2008, 371(9607), 117-125.
[http://dx.doi.org/10.1016/S0140-6736(08)60104-X] [PMID: 18191683]
[33]
American Diabetes Association. 9. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2018. Diabetes Care, 2018, 41(1), S86-S104.
[PMID: 29222380]
[34]
Collins, R.; Armitage, J.; Parish, S.; Sleigh, P.; Peto, R. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: A randomised placebo-controlled trial. Lancet, 2003, 361(9374), 2005-2016.
[http://dx.doi.org/10.1016/S0140-6736(03)13636-7] [PMID: 12814710]
[35]
van Hateren, K.J.J.; Landman, G.W.D.; Kleefstra, N.; Logtenberg, S.J.J.; Groenier, K.H.; Kamper, A.M.; Houweling, S.T.; Bilo, H.J.G. The lipid profile and mortality risk in elderly type 2 diabetic patients: A ten-year follow-up study (ZODIAC-13). PLoS One, 2009, 4(12), e8464.
[http://dx.doi.org/10.1371/journal.pone.0008464] [PMID: 20041116]
[36]
Langa, K.M.; Levine, D.A. The diagnosis and management of mild cognitive impairment: A clinical review. JAMA, 2014, 312(23), 2551-2561.
[http://dx.doi.org/10.1001/jama.2014.13806] [PMID: 25514304]
[37]
Hugo, J.; Ganguli, M. Dementia and cognitive impairment: Epidemiology, diagnosis, and treatment. Clin. Geriatr. Med., 2014, 30(3), 421-442.
[http://dx.doi.org/10.1016/j.cger.2014.04.001] [PMID: 25037289]
[38]
Peracino, A.; Pecorelli, S. The epidemiology of cognitive impairment in the aging population: Implications for hearing loss. Audiol. Neurotol., 2016, 21(1), 3-9.
[http://dx.doi.org/10.1159/000448346] [PMID: 27806351]
[39]
Qin, J.; He, Z.; Wu, L.; Wang, W.; Lin, Q.; Lin, Y.; Zheng, L. Prevalence of mild cognitive impairment in patients with hypertension: A systematic review and meta-analysis. Hypertens. Res., 2021, 44(10), 1251-1260.
[http://dx.doi.org/10.1038/s41440-021-00704-3] [PMID: 34285378]
[40]
Jamshidnejad-Tosaramandani, T.; Kashanian, S.; Al-Sabri, M.H.; Kročianová, D.; Clemensson, L.E.; Gentreau, M.; Schiöth, H.B. Statins and cognition: Modifying factors and possible underlying mechanisms. Front. Aging Neurosci., 2022, 14, 968039.
[http://dx.doi.org/10.3389/fnagi.2022.968039] [PMID: 36046494]
[41]
Patel, M.; Kothari, C. Critical review of statins: A bio-analytical perspective for therapeutic drug monitoring, TrAC Trends in Analytical Chemistry, 2017, 86, 206-21.
[http://dx.doi.org/10.1016/j.trac.2016.10.011]
[42]
Writing Committee; Lloyd-Jones, D.M.; Morris, P.B.; Ballantyne, C.M.; Birtcher, K.K.; Covington, A.M.; DePalma, S.M.; Minissian, M.B.; Orringer, C.E.; Smith, S.C.; Jr, Waring, A.A.; Wilkins, J.T. 2022 ACC expert consensus decision pathway on the role of nonstatin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: A report of the american college of cardiology solution set oversight committee. J. Am Coll Cardiol., 2022, 80(14), 1366-418.
[http://dx.doi.org/10.1016/j.jacc.2022.07.006]

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